| Sotorasib studied in …STUDIED_INderived45 of 45show fewer |
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| → studied in | NCT05564377Phase 2 · recruiting Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial · 45 trials list this drug (22 active) | — | — | Malignant Solid Neoplasm,Primary Peritoneal Carcinoma,Malignant Female Reproductive System Neoplasm+2 | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT05920356Phase 3 · recruiting A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202) · 45 trials list this drug (22 active) | — | — | Lung Non-Small Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT06497556Phase 3 · active not recruiting A Study Evaluating the Efficacy and Safety of Divarasib Versus Sotorasib or Adagrasib in Participants With Previously Treated KRAS G12C-positive Advanced or Metastatic Non-Small Cell Lung Cancer · 45 trials list this drug (22 active) | — | — | Lung Neoplasm,Lung Non-Small Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT05845450Phase 2 · recruiting Pre-operative Targeted Treatments in Molecularly Selected Resectable Colorectal Cancer (UNICORN) · 45 trials list this drug (22 active) | — | — | Colorectal Carcinoma,Malignant Colorectal Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT06582771Phase 2 · recruiting A Study of Sotorasib in People With Non-Small Cell Lung Cancer · 45 trials list this drug (22 active) | — | — | not mapped | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT07012031Phase 1/Phase 2 · recruiting Sotorasib in Combination With Trastuzumab Deruxtecan for the Treatment of Locally Advanced and Metastatic Non-small Cell Lung Cancer With a KRAS G12C Mutation · 45 trials list this drug (22 active) | — | — | Malignant Lung Neoplasm,Lung Non-Small Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT06252649Phase 3 · recruiting Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation · 45 trials list this drug (22 active) | — | — | Malignant Colorectal Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT06333678Phase 2 · terminated A Study Comparing Sotorasib With Durvalumab in People With Non-Small Cell Lung Cancer (NSCLC) · 45 trials list this drug (22 active) | — | — | Lung Non-Small Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT07543172Phase 2 · not yet recruiting CIMAvax-EGF With KRAS G12C Inhibitor for the Treatment of Advanced, KRAS G12C Mutated Non Small Cell Lung Cancer · 45 trials list this drug (22 active) | — | — | Malignant Lung Neoplasm,Lung Non-Small Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT04667234no longer available Expanded Access of Sotorasib · 45 trials list this drug (22 active) | — | — | Lung Non-Small Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT07172919Phase 2 · recruiting A Rollover Study Evaluating Sotorasib With or Without Panitumumab in Participants With KRAS p.G12C Mutation · 45 trials list this drug (22 active) | — | — | Solid Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT04303780Phase 3 · completed Study to Compare AMG 510 "Proposed INN Sotorasib" With Docetaxel in Non Small Cell Lung Cancer (NSCLC) (CodeBreak 200). · 45 trials list this drug (22 active) | — | — | not mapped | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT05198934Phase 3 · completed Sotorasib and Panitumumab Versus Investigator's Choice for Participants With Kirsten Rat Sarcoma (KRAS) p.G12C Mutation · 45 trials list this drug (22 active) | — | — | Malignant Colorectal Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT04933695Phase 2 · terminated A Study of Sotorasib (AMG 510) in Participants With Stage IV NSCLC Whose Tumors Harbor a KRAS p.G12C Mutation in Need of First-line Treatment · 45 trials list this drug (22 active) | — | — | Lung Non-Small Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT05118854Phase 2 · active not recruiting A Phase II Study of Neoadjuvant Sotorasib in Combination With Cisplatin or Carboplatin and Pemetrexed for Surgically Resectable Stage IIA-IIIB Non-Squamous Non-Small Cell Lung Cancer With a KRAS p.G12C Mutation · 45 trials list this drug (22 active) | — | — | Malignant Lung Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT03600883Phase 1/Phase 2 · completed A Phase 1/2, Study Evaluating the Safety, Tolerability, PK, and Efficacy of Sotorasib (AMG 510) in Subjects With Solid Tumors With a Specific KRAS Mutation (CodeBreaK 100) · 45 trials list this drug (22 active) | — | — | not mapped | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT07318389early Phase 1 · not yet recruiting ASCEND-CRC: Profiling and Targeting Dynamic Tumor Resistance in Patients With Metastatic Colorectal Cancer · 45 trials list this drug (22 active) | — | — | Colorectal Neoplasm,Malignant Colorectal Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT06333951Phase 1 · active not recruiting Anvumetostat Alone or in Combination With Other Therapies in Subjects With Advanced Thoracic Tumors With Homozygous MTAP-deletion (Master Protocol) (MTAPESTRY 104). · 45 trials list this drug (22 active) | — | — | Thoracic Neoplasm,Lung Non-Small Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT06807619Phase 1 · recruiting A Study of Sotorasib in People With Brain Tumors · 45 trials list this drug (22 active) | — | — | Brain Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT05638295Phase 2 · active not recruiting Testing the Use of AMG 510 (Sotorasib) and Panitumumab as a Targeted Treatment for KRAS G12C Mutant Solid Tumor Cancers (A ComboMATCH Treatment Trial) · 45 trials list this drug (22 active) | — | — | Malignant Solid Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT04380753Phase 1 · completed AMG 510 Ethnic Sensitivity Study (CodeBreaK 105). · 45 trials list this drug (22 active) | — | — | not mapped | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT07563738Phase 1/Phase 2 · recruiting A 2-part Phase 1/2 Open-label Trial on ODM-212 · 45 trials list this drug (22 active) | — | — | Malignant Mesothelioma,Malignant Pancreatic Neoplasm,Lung Non-Small Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT05398094Phase 2 · recruiting Clinical Trial of AMG510 in Stage III Unresectable NSCLC KRAS p.G12C Patients and Ineligible for Chemo-radiotherapy · 45 trials list this drug (22 active) | — | — | Lung Non-Small Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT04892017Phase 1 · terminated Study of Inlexisertib (DCC-3116) in Participants With RAS/MAPK Pathway Mutant Solid Tumors · 45 trials list this drug (22 active) | — | — | Solid Neoplasm,Lung Non-Small Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT07143513completed Real World Evaluation of Sotorasib Among Chinese Non-Small Cell Lung Cancer Patients · 45 trials list this drug (22 active) | — | — | Lung Non-Small Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT06249282Phase 1 · recruiting Carfilzomib in Combination With Sotorasib for the Treatment of Patients With KRAS G12C Mutated Advanced or Metastatic Non-small Cell Lung Cancer · 45 trials list this drug (22 active) | — | — | Malignant Lung Neoplasm,Lung Non-Small Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT06804824Phase 1 · recruiting A First-in-Human (FIH) Study to Evaluate the Safety and Tolerability of VVD-159642 in Participants With Advanced Solid Tumors · 45 trials list this drug (22 active) | — | — | Solid Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT05054725Phase 2 · completed Combination Study of RMC-4630 and Sotorasib for NSCLC Subjects With KRASG12C Mutation After Failure of Prior Standard Therapies · 45 trials list this drug (22 active) | — | — | Lung Non-Small Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT05815173Phase 1 · recruiting Ladarixin With Sotorasib in Advanced NSCLC · 45 trials list this drug (22 active) | — | — | not mapped | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT04625647Phase 2 · active not recruiting Testing the Use of Targeted Treatment (AMG 510) for KRAS G12C Mutated Advanced Non-squamous Non-small Cell Lung Cancer (A Lung-MAP Treatment Trial) · 45 trials list this drug (22 active) | — | — | Malignant Lung Neoplasm,Lung Non-Small Cell Carcinoma,Lung Adenocarcinoma+1 | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT04185883Phase 1 · active not recruiting Sotorasib Activity in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation (CodeBreak 101) · 45 trials list this drug (22 active) | — | — | Solid Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT05374538Phase 1 · terminated VIC-1911 Monotherapy in Combination With Sotorasib for the Treatment of KRAS G12C-Mutant Non-Small Cell Lung Cancer · 45 trials list this drug (22 active) | — | — | Lung Non-Small Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT04720976Phase 1/Phase 2 · completed JAB-3312 Based Combination Therapy in Adult Patients With Advanced Solid Tumors · 45 trials list this drug (22 active) | — | — | Solid Neoplasm,Lung Non-Small Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT05480865Phase 1 · terminated SHP2 Inhibitor BBP-398 in Combination With Sotorasib in Patients With Advanced Solid Tumors and a KRAS-G12C Mutation · 45 trials list this drug (22 active) | — | — | Solid Neoplasm,Adult Solid Neoplasm,Lung Non-Small Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT06068153Phase 2 · withdrawn AMG510 (sotorasib) Plus Lenvatinib As Second-line Treatment in Patients with KRASG12C Mutant, Metastatic NSCLC · 45 trials list this drug (22 active) | — | — | Lung Non-Small Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT06532149recruiting ERectile Dysfunctions, gOnadotoxicity and Sexual Health Assessment in Men With Lung Cancer · 45 trials list this drug (22 active) | — | — | Lung Non-Small Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT04092673Phase 1/Phase 2 · unknown Study of eFT226 in Subjects With Selected Advanced Solid Tumor Malignancies · 45 trials list this drug (22 active) | — | — | Adult Solid Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT06314763Phase 4 · completed Rivaroxaban Sotorasib Interaction Study · 45 trials list this drug (22 active) | — | — | not mapped | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT05815186Phase 2 · withdrawn Ladarixin With Sotorasib in Advanced NSCLC - Phase II · 45 trials list this drug (22 active) | — | — | not mapped | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT05311709Phase 2 · unknown Sotorasib in Advanced KRASG12C-mutated Non-small Cell Lung Cancer Patients With Comorbidities · 45 trials list this drug (22 active) | — | — | Malignant Neoplasm,Malignant Lung Neoplasm,Lung Non-Small Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT05180422Phase 1/Phase 2 · withdrawn A Phase I/II Study of AMG 510 in Combination With MVASI in Patients With Advanced, Unresectable or Metastatic KRAS G12C Mutant NSCLC With Asymptomatic Brain Metastasis · 45 trials list this drug (22 active) | — | — | Lung Non-Small Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT05045638Phase 1 · completed Effect of Coadministration of Sotorasib on the Pharmacokinetics of Rosuvastatin in Healthy Participants · 45 trials list this drug (22 active) | — | — | not mapped | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT04959981Phase 1 · completed A Study of Anti-Cancer Therapies Targeting the MAPK Pathway in Patients With Advanced NSCLC · 45 trials list this drug (22 active) | — | — | Lung Non-Squamous Non-Small Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT05251038Phase 1/Phase 2 · withdrawn Study of Sotorasib Combined With Chemotherapy for Second Line Treatment of Pancreas Cancer · 45 trials list this drug (22 active) | — | — | Malignant Pancreatic Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT05451056Phase 2 · unknown An Open-label, Phase 2trial of Sotorasib in KRAS G12C-mutant Non-small-cell Lung Cancer(NSCLC) Patients and a Translational Study to Find Acquired Resistance Mechanism to Sotorasib · 45 trials list this drug (22 active) | — | — | Lung Non-Small Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |