Rogaratinib

small molecule

Identifier: CI-DRUG-00000526
Entity page: /drug/rogaratinib ↗
Edges: 27

Neighbours: 11 cancers4 genes1 variants10 trials
Drawn: 26 of 26 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Rogaratinib predicts response to …PREDICTS_RESPONSE_TO1 of 1
← predicts response to	FGFR1 Amplificationamplification 2 source records aggregated	sensitivity	D	Malignant Breast Neoplasm	2	Curated	civic	graph →
Rogaratinib targets …TARGETS4 of 4
targets

Rogaratinib investigated for …INVESTIGATED_FOR5 of 5
→ investigated for	Malignant Breast Neoplasmcancer_family 2 source records aggregated	supports	D	Malignant Breast Neoplasm	2	Curated	civic	graph →
→ investigated for	Bladder Neoplasmsubtype	unknown	2	Bladder Neoplasm	1	Curated	chembl	graph →
→ investigated for	Neoplasmcancer_family	unknown	2	Neoplasm	1	Curated	chembl	graph →
→ investigated for	Lung Non-Small Cell Carcinomasubtype	unknown	2	Lung Non-Small Cell Carcinoma	1	Curated	chembl	graph →
→ investigated for	Breast Neoplasmcancer_family	unknown	1	Breast Neoplasm	1	Curated	chembl	graph →

Rogaratinib investigated for …INVESTIGATED_FOR5 of 5

→ investigated for

Malignant Breast Neoplasmcancer_family

2 source records aggregated

supports

Malignant Breast Neoplasm

Curated

Rogaratinib investigated in trials for …INVESTIGATED_IN_TRIALSderived7 of 7
→ investigated in trials for	Neoplasmcancer_family 3 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Neoplasm	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Gastrointestinal Stromal Tumor 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Gastrointestinal Stromal Tumor	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Bladder Neoplasm 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Bladder Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Neoplasm 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Sarcoma 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Sarcoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Transitional Cell Carcinoma 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Transitional Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Urothelial Carcinoma 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Urothelial Carcinoma	1	Observed	clinicaltrials	graph →

Rogaratinib studied in …STUDIED_INderived10 of 10
→ studied in	NCT04595747Phase 2 · active not recruiting Testing the Anti-cancer Drug, Rogaratinib (BAY 1163877), for Treatment of Advanced Sarcoma With Alteration in Fibroblast Growth Factor Receptor (FGFR 1-4), and in Patients With SDH-deficient Gastrointestinal Stromal Tumor (GIST) · 10 trials list this drug (1 active)	—	—	Sarcoma,Gastrointestinal Stromal Tumor	1	Observed	clinicaltrials	graph →
→ studied in	NCT03473756Phase 1 · completed Phase 1b/2 Study of Rogaratinib (BAY1163877) in Combination With Atezolizumab in Urothelial Carcinoma · 10 trials list this drug (1 active)	—	—	Urothelial Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT03762122Phase 2 · terminated Rogaratinib in Patients With Advanced Pretreated Squamous-cell Non-small Cell Lung Cancer (SQCLC) · 10 trials list this drug (1 active)	—	—	not mapped	1	Observed	clinicaltrials	graph →
→ studied in	NCT03410693Phase 2/Phase 3 · completed Study of Rogaratinib (BAY1163877) vs Chemotherapy in Patients With FGFR (Fibroblast Growth Factor Receptor)-Positive Locally Advanced or Metastatic Urothelial Carcinoma · 10 trials list this drug (1 active)	—	—	Transitional Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT03517956Phase 1 · completed Phase 1 Study of the Combination of Rogaratinib With Copanlisib in Patients With Fibroblast Growth Factor Receptor (FGFR)-Positive, Locally Advanced or Metastatic Solid Tumors · 10 trials list this drug (1 active)	—	—	not mapped	1	Observed	clinicaltrials	graph →
→ studied in	NCT04125693Phase 2 · completed Roll-over Study to Continue Treatment With the Investigational Drug Rogaratinib and to Further Test Its Safety · 10 trials list this drug (1 active)	—	—	Malignant Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT01976741Phase 1 · completed Dose Escalation Pan-FGFR (Fibroblast Growth Factor Receptor) Inhibitor (Rogaratinib) · 10 trials list this drug (1 active)	—	—	Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT03788603Phase 1 · completed Rogaratinib (BAY1163877) in Chinese Patients · 10 trials list this drug (1 active)	—	—	Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT04040725Phase 2 · withdrawn Rogaratinib for BCG Refractory High Risk Non-Muscle Invasive Bladder Cancer With FGFR1/2 Overexpression · 10 trials list this drug (1 active)	—	—	Malignant Bladder Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT02592785Phase 1 · completed Phase I Dose Escalation Study of BAY 1163877 (Rogaratinib) in Japanese Subjects With Refractory, Locally Advanced or Metastatic Solid Tumors · 10 trials list this drug (1 active)	—	—	Neoplasm	1	Observed	clinicaltrials	graph →

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