Ripretinib

small molecule

Identifier: CI-DRUG-00000523
Entity page: /drug/ripretinib ↗
Edges: 23

Neighbours: 4 cancers2 genes10 trials3 approvals
Drawn: 19 of 19 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Ripretinib approved for …APPROVED_FOR4 of 3
→ approved for	Gastrointestinal Stromal Tumorsubtype	supports	mesh_therapeutic_area	Gastrointestinal Stromal Tumor	1	Regulatory	ema	graph →
→ approved for	EMA · EU · 2021Qinlock is indicated for the treatment of adult patients with advanced gastrointestinal stromal tumour (GIST) who have received prior treatment with three or more kinase inhibitors, including imatinib.

Ripretinib targets …TARGETS2 of 2
→ targets	KIT	—	INHIBITOR	—	1	Curated	chembl	graph →
→ targets	PDGFRA	—	INHIBITOR	—	1	Curated	chembl	graph →

Ripretinib targets …TARGETS2 of 2

→ targets

KIT

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INHIBITOR

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Curated

Ripretinib investigated for …INVESTIGATED_FOR2 of 2
→ investigated for	Neoplasmcancer_family	unknown	4	Neoplasm	1	Curated	chembl	graph →
→ investigated for	Gastrointestinal Stromal Tumorsubtype	unknown	4	Gastrointestinal Stromal Tumor	1	Curated	chembl	graph →

Ripretinib investigated in trials for …INVESTIGATED_IN_TRIALSderived3 of 3
→ investigated in trials for	Gastrointestinal Stromal Tumorsubtype 13 trials (4 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Gastrointestinal Stromal Tumor	13	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Mastocytosis 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Mastocytosis	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Neoplasm 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Neoplasm	1	Observed	clinicaltrials	graph →

Ripretinib studied in …STUDIED_INderived10 of 13show all (up to 200)
→ studied in	NCT05957367Phase 1/Phase 2 · recruiting A Study of Inlexisertib (DCC-3116) in Combination With Anticancer Therapies in Participants With Advanced Malignancies · 13 trials list this drug (4 active)	—	—	Gastrointestinal Stromal Tumor	1	Observed	clinicaltrials	graph →
→ studied in	NCT07618377Phase 1 · recruiting Study of DCC-2618 in Patients With GIST After at Least 3 Prior Treatments · 13 trials list this drug (4 active)	—	—	Gastrointestinal Stromal Tumor	1	Observed	clinicaltrials	graph →
→ studied in	NCT04633122Phase 2 · completed A Study to Assess DCC-2618 and Sunitinib in Patients With Advanced GIST After Treatment With Imatinib · 13 trials list this drug (4 active)	—	—	Gastrointestinal Stromal Tumor	1	Observed	clinicaltrials	graph →
→ studied in	NCT03673501Phase 3 · active not recruiting A Study of Ripretinib vs Sunitinib in Advanced GIST Patients After Treatment With Imatinib · 13 trials list this drug (4 active)	—	—	Gastrointestinal Stromal Tumor	1	Observed	clinicaltrials	graph →
→ studied in	NCT05734105Phase 3 · active not recruiting A Study of Ripretinib vs Sunitinib in Patients With Advanced GIST With Specific KIT Exon Mutations Who Were Previously Treated With Imatinib · 13 trials list this drug (4 active)	—	—	Gastrointestinal Stromal Tumor	1	Observed	clinicaltrials	graph →
→ studied in	NCT06619275completed Ripretinib (QINLOCK®) According to Current SmPC · 13 trials list this drug (4 active)	—	—	Gastrointestinal Stromal Tumor	1	Observed	clinicaltrials	graph →
→ studied in	NCT04282980Phase 2 · completed A Study of DCC-2618 (Ripretinib) In Patients With With Advanced Gastrointestinal Stromal Tumors (GIST) · 13 trials list this drug (4 active)	—	—	Gastrointestinal Stromal Tumor	1	Observed	clinicaltrials	graph →
→ studied in	NCT04530981Phase 1 · completed A Drug-Drug Interaction Study to Evaluate the Effect of Ripretinib on the Pharmacokinetics of a CYP2C8 Probe Substrate in Patients with Advanced GIST · 13 trials list this drug (4 active)	—	—	Gastrointestinal Stromal Tumor	1	Observed	clinicaltrials	graph →
→ studied in	NCT02571036Phase 1 · completed A Safety, Tolerability and PK Study of DCC-2618 in Patients With Advanced Malignancies · 13 trials list this drug (4 active)	—	—	Malignant Neoplasm,Malignant Mastocytosis,Gastrointestinal Stromal Tumor	1	Observed	clinicaltrials	graph →
→ studied in	NCT05697107unknown Ripretinib in Chinese Patients With Advanced GIST: a Real World Study · 13 trials list this drug (4 active)	—	—	Gastrointestinal Stromal Tumor	1	Observed	clinicaltrials	graph →

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