Pyrotinib

small molecule

Identifier: CI-DRUG-00000492
Entity page: /drug/pyrotinib ↗
Edges: 133

Neighbours: 18 cancers2 genes10 trials
Drawn: 30 of 30 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Pyrotinib targets …TARGETS2 of 2
→ targets	ERBB2	—	INHIBITOR	—	1	Curated	chembl	graph →
→ targets	EGFR	—	INHIBITOR	—	1	Curated	chembl

Pyrotinib investigated for …INVESTIGATED_FOR7 of 7
→ investigated for	Breast Neoplasmcancer_family	unknown	3	Breast Neoplasm	1	Curated	chembl	graph →
→ investigated for	Lung Non-Small Cell Carcinomasubtype	unknown	3	Lung Non-Small Cell Carcinoma	1	Curated	chembl	graph →
→ investigated for	Digestive System Neoplasmcancer_family	unknown	2	Digestive System Neoplasm	1	Curated	chembl	graph →
→ investigated for	Colorectal Neoplasmsubtype	unknown	2	Colorectal Neoplasm	1	Curated	chembl	graph →
→ investigated for	Gastric Neoplasmcancer_family	unknown	2	Gastric Neoplasm	1	Curated	chembl	graph →
→ investigated for	Neoplasmcancer_family	unknown	2	Neoplasm	1	Curated	chembl	graph →
→ investigated for	Triple-Negative Breast Carcinomamolecular_subtype	unknown	2	Triple-Negative Breast Carcinoma	1	Curated	chembl	graph →

Pyrotinib investigated for …INVESTIGATED_FOR7 of 7

→ investigated for

Breast Neoplasmcancer_family

unknown

Breast Neoplasm

Curated

Pyrotinib investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 17show all (up to 200)
→ investigated in trials for	Malignant Breast Neoplasm 51 trials (22 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Breast Neoplasm	51	Observed	clinicaltrials	graph →
→ investigated in trials for	HER2-Positive Breast Carcinoma 24 trials (15 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	HER2-Positive Breast Carcinoma	24	Observed	clinicaltrials	graph →
→ investigated in trials for	Breast Neoplasmcancer_family 14 trials (9 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Breast Neoplasm	14	Observed	clinicaltrials	graph →
→ investigated in trials for	Lung Non-Small Cell Carcinomasubtype 8 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lung Non-Small Cell Carcinoma	8	Observed	clinicaltrials	graph →
→ investigated in trials for	Solid Neoplasm 4 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Solid Neoplasm	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Colorectal Neoplasm 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Colorectal Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Rare Neoplasm 2 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Rare Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Digestive System Neoplasmcancer_family 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Digestive System Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Early Stage Breast Carcinoma 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Early Stage Breast Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Gastric Neoplasmcancer_family 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Gastric Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Gastroesophageal Junction Adenocarcinoma 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Gastroesophageal Junction Adenocarcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Biliary Tract Neoplasm 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Biliary Tract Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Gastric Neoplasm 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Gastric Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Lung Neoplasm 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Lung Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Neoplasm 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Neoplasm	1	Observed	clinicaltrials	graph →

Pyrotinib studied in …STUDIED_INderived10 of 107show all (up to 200)
→ studied in	NCT07836257Phase 2 · not yet recruiting A Phase II Study of Trastuzumab Deruxtecan (T-DXd) Plus Pyrotinib in HER2-Positive Advanced Breast Cancer After Progression on T-DXd · 107 trials list this drug (52 active)	—	—	Malignant Breast Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT05745740Phase 1/Phase 2 · not yet recruiting A Study of RC48-ADC Combined With Pyrotinib For Treatment of Local Advanced or Metastasis NSCLC With HER2 Mutation · 107 trials list this drug (52 active)	—	—	Lung Non-Small Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07810634active not recruiting Pyrotinib for HER2-Positive Advanced Breast Cancer Previously Treated With Trastuzumab and Pertuzumab · 107 trials list this drug (52 active)	—	—	Malignant Breast Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT07797218Phase 3 · recruiting Neoadjuvant Pyrotinib-to-pertuzumab in HER2+ eBC · 107 trials list this drug (52 active)	—	—	Breast Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT03980054Phase 3 · active not recruiting A Study of Evaluating The Effects Of Pyrotinib After Adjuvant Trastuzumab In Women With Early Stage Breast Cancer · 107 trials list this drug (52 active)	—	—	Malignant Breast Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT07766772Phase 2 · not yet recruiting Trastuzumab Rezetecan Followed by Pyrotinib, and Trastuzumab Combined With Capecitabine as First-line Treatment for Advanced HER2-positive Breast Cancer · 107 trials list this drug (52 active)	—	—	Breast Neoplasm,Malignant Breast Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT07708194Phase 1/Phase 2 · recruiting Entinostat Plus Pyrotinib and Endocrine Therapy in Advanced Triple-Positive Breast Cancer After Trastuzumab Failure · 107 trials list this drug (52 active)	—	—	Breast Neoplasm,Malignant Breast Neoplasm,HER2-Positive Breast Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07600164Phase 4 · recruiting Real-world Study of Pyrotinib-containing Regimens of Advanced HER2-positive Breast Cancer · 107 trials list this drug (52 active)	—	—	Breast Neoplasm,Malignant Breast Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT07635342Phase 2 · recruiting Pyrotinib Plus Trastuzumab and Chemotherapy for HER2-Positive Early Breast Cancer · 107 trials list this drug (52 active)	—	—	HER2-Positive Breast Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT05582499Phase 2 · recruiting Fudan University Shanghai Cancer Center Breast Cancer Precision Platform Series Study- Neoadjuvant Therapy · 107 trials list this drug (52 active)	—	—	Breast Neoplasm,Malignant Breast Neoplasm,Early Stage Breast Carcinoma+2	1	Observed	clinicaltrials	graph →

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