| Nirogacestat studied in …STUDIED_INderived27 of 27show fewer |
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| → studied in | NCT04722146Phase 1 · active not recruiting A Study of Teclistamab With Other Anticancer Therapies in Participants With Multiple Myeloma · 27 trials list this drug (14 active) | — | — | Multiple Myeloma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT07170644Phase 2 · active not recruiting A Study of Nirogacestat in Japanese Adults With Desmoid Tumors/Aggressive Fibromatosis (DT/AF) · 27 trials list this drug (14 active) | — | — | Desmoid Fibromatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT07176689Phase 4 · recruiting Nirogacestat in Premenopausal Females With Desmoid Tumor/Aggressive Fibromatosis (DT/AF) · 27 trials list this drug (14 active) | — | — | Desmoid Fibromatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT05949099Phase 2 · recruiting Study of Cryoablation and Nirogacestat for Desmoid Tumor · 27 trials list this drug (14 active) | — | — | Desmoid Fibromatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT05348356Phase 2 · completed Nirogacestat in Ovarian Granulosa Cell Tumors · 27 trials list this drug (14 active) | — | — | Malignant Ovarian Neoplasm,Ovarian Granulosa Cell Tumor,Ovarian Granulosa-Stromal Cell Tumor | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT03785964Phase 3 · completed Nirogacestat for Adults With Desmoid Tumor/Aggressive Fibromatosis (DT/AF) · 27 trials list this drug (14 active) | — | — | Desmoid Fibromatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT05879146Phase 2 · recruiting Evaluation of the Response and Non-response of Nirogacestat in Desmoid Tumors- Clinical Study · 27 trials list this drug (14 active) | — | — | Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT04195399Phase 2 · active not recruiting A Study of a New Drug, Nirogacestat, for Treating Desmoid Tumors That Cannot be Removed by Surgery · 27 trials list this drug (14 active) | — | — | Desmoid Fibromatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT05556798Phase 1 · active not recruiting A Study of Belantamab Mafodotin in Combination With Nirogacestat and Pomalidomide in People With Multiple Myeloma That Has Not Responded to Treatment or Has Come Back After Treatment · 27 trials list this drug (14 active) | — | — | Multiple Myeloma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT05137054Phase 1 · recruiting A Study to Examine the Effects of Novel Therapy Linvoseltamab in Combination With Other Cancer Treatments for Adult Participants With Multiple Myeloma That is Resistant to Current Standard of Care Treatments · 27 trials list this drug (14 active) | — | — | Multiple Myeloma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT07150104Phase 1/Phase 2 · active not recruiting Sub-study of Belantamab Mafodotin (GSK2857916) as Monotherapy and in Combination With Nirogacestat, Pomalidomide, and Dexamethasone in Participants With RRMM · 27 trials list this drug (14 active) | — | — | Multiple Myeloma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT07150091Phase 1/Phase 2 · active not recruiting Sub-study of Belantamab Mafodotin (GSK2857916) in Combination With Nirogacestat, Lenalidomide, and Dexamethasone in Participants With RRMM · 27 trials list this drug (14 active) | — | — | Multiple Myeloma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT07539454Phase 2 · not yet recruiting Nirogacestat in Patients With Kaposi Sarcoma · 27 trials list this drug (14 active) | — | — | AIDS-Related Kaposi Sarcoma,Skin Kaposi Sarcoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT04093596Phase 1 · completed Safety and Efficacy of ALLO-715 BCMA Allogenic CAR T Cells in in Adults With Relapsed or Refractory Multiple Myeloma (UNIVERSAL) · 27 trials list this drug (14 active) | — | — | Multiple Myeloma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT05041036available Individual Patient Compassionate Use of Nirogacestat · 27 trials list this drug (14 active) | — | — | Desmoid Fibromatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT04126200Phase 1/Phase 2 · active not recruiting Platform Study of Belantamab Mafodotin as Monotherapy and in Combination With Anti-cancer Treatments in Participants With Relapsed/Refractory Multiple Myeloma (RRMM) · 27 trials list this drug (14 active) | — | — | Multiple Myeloma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT07084896Phase 1/Phase 2 · active not recruiting Sub-study of Belantamab Mafodotin (GSK2857916) in Combination With Nirogacestat in Participants With RRMM · 27 trials list this drug (14 active) | — | — | Multiple Myeloma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01981551Phase 2 · completed Phase II Trial of the Gamma-Secretase Inhibitor PF-03084014 in Adults With Desmoid Tumors/Aggressive Fibromatosis · 27 trials list this drug (14 active) | — | — | Desmoid Fibromatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT05573802Phase 1/Phase 2 · recruiting A Study to Investigate Safety and Clinical Activity of Belantamab Mafodotin in Combination With Lenalidomide, Dexamethasone and Nirogacestat in Patients With Transplant Ineligible Newly Diagnosed Multiple Myeloma · 27 trials list this drug (14 active) | — | — | Neoplasm,Multiple Myeloma,Plasma Cell Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT04171843Phase 1 · terminated A Dose-escalation Study to Evaluate the Safety and Clinical Activity of PBCAR269A, With or Without Nirogacestat, in Study Participants With Relapsed/Refractory Multiple Myeloma · 27 trials list this drug (14 active) | — | — | Multiple Myeloma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT00878189Phase 1 · completed A Trial In Patients With Advanced Cancer And Leukemia · 27 trials list this drug (14 active) | — | — | Leukemia | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01876251Phase 1 · terminated A Study Evaluating The PF-03084014 In Combination With Docetaxel In Patients With Advanced Breast Cancer · 27 trials list this drug (14 active) | — | — | not mapped | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02955446no longer available Compassionate Use Protocol for PF-03084014 in Patients With Advanced Solid Tumor Malignancies · 27 trials list this drug (14 active) | — | — | Neoplasm,Desmoid Fibromatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02109445Phase 2 · terminated Study Of PF-03084014 In Combination With Gemcitabine And Nab-Paclitaxel In Patients With Metastatic Pancreatic Adenocarcinoma Not Previously Treated With Anticancer Therapies · 27 trials list this drug (14 active) | — | — | Pancreatic Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02299635Phase 2 · terminated A Study Evaluating PF-03084014 In Patients With Advanced Breast Cancer With Or Without Notch Alterations · 27 trials list this drug (14 active) | — | — | Triple-Negative Breast Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02338531Phase 2 · withdrawn Biomarker Research Study for PF-03084014 in cHEmoresistant Triple-negative Breast cAncer · 27 trials list this drug (14 active) | — | — | Malignant Breast Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02462707Phase 1 · withdrawn A Study Of PF-03084014 In Japanese Patients With Advanced Solid Tumors · 27 trials list this drug (14 active) | — | — | Solid Neoplasm | 1 | Observed | clinicaltrials | graph → |