Lisocabtagene Maraleucel

gene therapy

Identifier: CI-DRUG-00000750
Entity page: /drug/lisocabtagene-maraleucel ↗
Edges: 60

Neighbours: 17 cancers1 genes10 trials2 approvals
Drawn: 30 of 30 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Lisocabtagene Maraleucel approved for …APPROVED_FOR6 of 4
→ approved for	Mantle Cell Lymphomahematologic_malignancy	supports	EMA indication text	Mantle Cell Lymphoma	1	Regulatory	ema	graph →
→ approved for	Mediastinal Neoplasmcancer_family	supports	mesh_therapeutic_area

Lisocabtagene Maraleucel targets …TARGETS1 of 1
→ targets	CD19	—	BINDING AGENT	—	1	Curated	chembl	graph →

Lisocabtagene Maraleucel targets …TARGETS1 of 1

→ targets

CD19

—

BINDING AGENT

—

Curated

Lisocabtagene Maraleucel investigated for …INVESTIGATED_FOR6 of 6
→ investigated for	Non-Hodgkin Lymphomahematologic_malignancy	unknown	3	Non-Hodgkin Lymphoma	1	Curated	chembl	graph →
→ investigated for	Lymphomacancer_family	unknown	2	Lymphoma	1	Curated	chembl	graph →
→ investigated for	Follicular Lymphomahematologic_malignancy	unknown	1	Follicular Lymphoma	1	Curated	chembl	graph →
→ investigated for	Mantle Cell Lymphomahematologic_malignancy	unknown	1	Mantle Cell Lymphoma	1	Curated	chembl	graph →
→ investigated for	Acute Lymphoblastic Leukemiahematologic_malignancy	unknown	1	Acute Lymphoblastic Leukemia	1	Curated	chembl	graph →
→ investigated for	Chronic Lymphocytic Leukemiahematologic_malignancy	unknown	1	Chronic Lymphocytic Leukemia	1	Curated	chembl	graph →

Lisocabtagene Maraleucel investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 26show all (up to 200)
→ investigated in trials for	Non-Hodgkin Lymphomahematologic_malignancy 8 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Non-Hodgkin Lymphoma	8	Observed	clinicaltrials	graph →
→ investigated in trials for	Diffuse Large B-Cell Lymphomahematologic_malignancy 7 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Diffuse Large B-Cell Lymphoma	7	Observed	clinicaltrials	graph →
→ investigated in trials for	Primary Mediastinal Large B-Cell Lymphoma 5 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Primary Mediastinal Large B-Cell Lymphoma	5	Observed	clinicaltrials	graph →
→ investigated in trials for	B-Cell Malignant Neoplasm 4 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	B-Cell Malignant Neoplasm	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Grade 3b Follicular Lymphoma 4 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Grade 3b Follicular Lymphoma	4	Observed	clinicaltrials	graph →
→ investigated in trials for	High Grade B-Cell Lymphoma 4 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	High Grade B-Cell Lymphoma	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Lymphomacancer_family 4 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lymphoma	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Chronic Lymphocytic Leukemiahematologic_malignancy 2 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Chronic Lymphocytic Leukemia	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Follicular Lymphomahematologic_malignancy 2 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Follicular Lymphoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Small Lymphocytic Lymphoma 2 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Small Lymphocytic Lymphoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Acute Lymphoblastic Leukemiahematologic_malignancy 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Acute Lymphoblastic Leukemia	1	Observed	clinicaltrials	graph →
→ investigated in trials for	B-Cell Non-Hodgkin Lymphoma 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	B-Cell Non-Hodgkin Lymphoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Diffuse Large B-Cell Lymphoma, Not Otherwise Specified Molecular Subtypes 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Diffuse Large B-Cell Lymphoma, Not Otherwise Specified Molecular Subtypes	1	Observed	clinicaltrials	graph →
→ investigated in trials for	EBV-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	EBV-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified	1	Observed	clinicaltrials	graph →

Lisocabtagene Maraleucel studied in …STUDIED_INderived10 of 23show all (up to 200)
→ studied in	NCT05359211Phase 1 · completed NKTR-255 in Combination With CAR-T Cell Therapy for the Treatment of Relapsed or Refractory Large B-cell Lymphoma · 23 trials list this drug (14 active)	—	—	Diffuse Large B-Cell Lymphoma,Primary Mediastinal Large B-Cell Lymphoma,Transformed Indolent B-Cell Non-Hodgkin Lymphoma to Diffuse Large B-Cell Lymphoma+1	1	Observed	clinicaltrials	graph →
→ studied in	NCT07098364Phase 1/Phase 2 · suspended ST-067 in Combination With CD19-Directed CAR T-Cell Therapy (Liso-cel) in Relapsed/Refractory Large B-Cell Lymphoma · 23 trials list this drug (14 active)	—	—	Diffuse Large B-Cell Lymphoma,Indolent B-Cell Non-Hodgkin Lymphoma,Primary Mediastinal Large B-Cell Lymphoma+2	1	Observed	clinicaltrials	graph →
→ studied in	NCT07194980Phase 2 · recruiting Nemtabrutinib and Lisocabtagene Maraleucel for the Treatment of Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma · 23 trials list this drug (14 active)	—	—	Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07777120active not recruiting Liso-Cel in Relapsed/Refractory Marginal Zone Lymphoma · 23 trials list this drug (14 active)	—	—	Marginal Zone Lymphoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT05075603Phase 1 · completed Relapsed/Refractory Large B-cell Lymphoma With NT-I7 Post-CD19 CAR T-cell Therapy · 23 trials list this drug (14 active)	—	—	Diffuse Large B-Cell Lymphoma,Primary Mediastinal Large B-Cell Lymphoma,High Grade B-Cell Lymphoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07188558Phase 3 · recruiting A Study to Investigate Ronde-cel Versus Investigator's Choice CD19 CAR T-Cell Therapy · 23 trials list this drug (14 active)	—	—	B-Cell Malignant Neoplasm,Non-Hodgkin Lymphoma,Diffuse Large B-Cell Lymphoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07711483Phase 2 · not yet recruiting GLORY: Glofit-GemOx With Liso-Cel For Lymphoma · 23 trials list this drug (14 active)	—	—	B-Cell Malignant Neoplasm,Lymphoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT03331198Phase 1/Phase 2 · active not recruiting Study Evaluating Safety and Efficacy of JCAR017 in Subjects With Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL) · 23 trials list this drug (14 active)	—	—	Leukemia,Small Lymphocytic Lymphoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT05672173Phase 2 · active not recruiting Lisocabtagene Maraleucel, Nivolumab and Ibrutinib for the Treatment of Richter's Transformation · 23 trials list this drug (14 active)	—	—	not mapped	1	Observed	clinicaltrials	graph →
→ studied in	NCT05873712Phase 2 · recruiting Zanubrutinib and Lisocabtagene Maraleucel for the Treatment of Richter's Syndrome · 23 trials list this drug (14 active)	—	—	Transformed B-Cell Non-Hodgkin Lymphoma,Transformed Non-Hodgkin Lymphoma,Transformed Chronic Lymphocytic Leukemia to Diffuse Large B-Cell Lymphoma	1	Observed	clinicaltrials	graph →

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