Imiquimod

small molecule

Identifier: CI-DRUG-00000781
Entity page: /drug/imiquimod ↗
Edges: 210

Neighbours: 27 cancers1 genes10 trials3 approvals
Drawn: 41 of 41 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Imiquimod approved for …APPROVED_FOR5 of 3
→ approved for	Basal Cell Carcinomahistology	supports	mesh_therapeutic_area	Basal Cell Carcinoma	1	Regulatory	ema	graph →
→ approved for	Superficial Basal Cell Carcinomasubtype	supports	EMA indication text

Imiquimod targets …TARGETS1 of 1
→ targets	TLR7	—	AGONIST	—	1	Curated	chembl	graph →

Imiquimod targets …TARGETS1 of 1

→ targets

TLR7

—

AGONIST

—

Curated

Imiquimod investigated for …INVESTIGATED_FOR15 of 31show all (up to 200)
→ investigated for	Basal Cell Carcinomahistology	unknown	4	Basal Cell Carcinoma	1	Curated	chembl	graph →
→ investigated for	Cervical Intraepithelial Neoplasiaprecursor_condition	unknown	3	Cervical Intraepithelial Neoplasia	1	Curated	chembl	graph →
→ investigated for	Extramammary Paget Diseasehistology	unknown	3	Extramammary Paget Disease	1	Curated	chembl	graph →
→ investigated for	Vulvar Neoplasmsubtype	unknown	3	Vulvar Neoplasm	1	Curated	chembl	graph →
→ investigated for	Squamous Cell Carcinoma In Situhistology	unknown	2	Squamous Cell Carcinoma In Situ	1	Curated	chembl	graph →
→ investigated for	Breast Neoplasmcancer_family	unknown	2	Breast Neoplasm	1	Curated	chembl	graph →
→ investigated for	Carcinoma In Situhistology	unknown	2	Carcinoma In Situ	1	Curated	chembl	graph →
→ investigated for	Hemangiomasubtype	unknown	2	Hemangioma	1	Curated	chembl	graph →
→ investigated for	Lung Non-Small Cell Carcinomasubtype	unknown	2	Lung Non-Small Cell Carcinoma	1	Curated	chembl	graph →
→ investigated for	Leukemiacancer_family	unknown	2	Leukemia	1	Curated	chembl	graph →
→ investigated for	Chronic Lymphocytic Leukemiahematologic_malignancy	unknown	2	Chronic Lymphocytic Leukemia	1	Curated	chembl	graph →
→ investigated for	Cervical Neoplasmsubtype	unknown	2	Cervical Neoplasm	1	Curated	chembl	graph →
→ investigated for	Melanomacancer_family	unknown	2	Melanoma	1	Curated	chembl	graph →
→ investigated for	Paragangliomasubtype	unknown	1	Paraganglioma	1	Curated	chembl	graph →
→ investigated for	Neoplasmcancer_family	unknown	1	Neoplasm	1	Curated	chembl	graph →

Imiquimod investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 61show all (up to 200)
→ investigated in trials for	Basal Cell Carcinomahistology 12 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Basal Cell Carcinoma	12	Observed	clinicaltrials	graph →
→ investigated in trials for	Cervical Intraepithelial Neoplasiaprecursor_condition 9 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Cervical Intraepithelial Neoplasia	9	Observed	clinicaltrials	graph →
→ investigated in trials for	Melanomacancer_family 8 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Melanoma	8	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Breast Neoplasm 5 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Breast Neoplasm	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Glioblastoma 4 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Glioblastoma	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Lentigo Maligna 4 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lentigo Maligna	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Condyloma Acuminatum 3 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Condyloma Acuminatum	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Neoplasm 3 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Neoplasm	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Anaplastic Astrocytoma 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Anaplastic Astrocytoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Cervical Intraepithelial Neoplasia Grade 2/3 2 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Cervical Intraepithelial Neoplasia Grade 2/3	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Chronic Lymphocytic Leukemiahematologic_malignancy 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Chronic Lymphocytic Leukemia	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Ependymoma 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Ependymoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	High Grade Squamous Intraepithelial Neoplasia 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	High Grade Squamous Intraepithelial Neoplasia	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Cervical Neoplasm 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Cervical Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Colorectal Neoplasm 2 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Colorectal Neoplasm	2	Observed	clinicaltrials	graph →

Imiquimod studied in …STUDIED_INderived10 of 114show all (up to 200)
→ studied in	NCT05212246Phase 3 · not yet recruiting Basal Cell Carcinoma Chemoprevention Trial · 114 trials list this drug (8 active)	—	—	Basal Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT00799110Phase 2 · terminated Vaccination of Patients With Ovarian Cancer With Dendritic Cell/Tumor Fusions With Granulocyte Macrophage Colony-stimulating Factor (GM-CSF) and Imiquimod · 114 trials list this drug (8 active)	—	—	Malignant Fallopian Tube Neoplasm,Malignant Ovarian Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT07679841Phase 1/Phase 2 · not yet recruiting Safety and Efficacy of Nivolumab and Imiquimod Combination in Vulvar Squamous Cell Carcinoma Patients · 114 trials list this drug (8 active)	—	—	Vulvar Squamous Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT03872947Phase 1 · active not recruiting A Study of TRK-950 in Combinations With Anti-Cancer Treatment Regimens in Patients With Advanced Solid Tumors · 114 trials list this drug (8 active)	—	—	Solid Neoplasm,Melanoma,Malignant Gastric Neoplasm+2	1	Observed	clinicaltrials	graph →
→ studied in	NCT02600949Phase 1 · enrolling by invitation Personalized Peptide Vaccine in Treating Patients With Advanced Pancreatic Cancer or Colorectal Cancer · 114 trials list this drug (8 active)	—	—	Colorectal Neoplasm,Colorectal Adenocarcinoma,Malignant Colorectal Neoplasm+1	1	Observed	clinicaltrials	graph →
→ studied in	NCT05838599early Phase 1 · recruiting Combining Topical Imiquimod With Local Radiotherapy for Treatment of Mycosis Fungoides · 114 trials list this drug (8 active)	—	—	Mycosis Fungoides	1	Observed	clinicaltrials	graph →
→ studied in	NCT03276832early Phase 1 · completed Imiquimod and Pembrolizumab in Treating Patients With Stage IIIB-IV Melanoma · 114 trials list this drug (8 active)	—	—	Melanoma,Cutaneous Melanoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07210775Phase 1/Phase 2 · recruiting Topical Imiquimod Treatment of Oral Dysplasia · 114 trials list this drug (8 active)	—	—	not mapped	1	Observed	clinicaltrials	graph →
→ studied in	NCT01795313Phase 1 · terminated Immunotherapy for Recurrent Ependymomas in Children Using Tumor Antigen Peptides With Imiquimod · 114 trials list this drug (8 active)	—	—	Ependymoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT03534947Phase 2 · completed A Study to Evaluate Neoadjuvant Sonidegib Followed by Surgery or Imiquimod in the Management of Basal Cell Carcinoma · 114 trials list this drug (8 active)	—	—	Malignant Skin Neoplasm,Basal Cell Carcinoma,Invasive Carcinoma+1	1	Observed	clinicaltrials	graph →

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