Guadecitabine

small molecule

Identifier: CI-DRUG-00000660
Entity page: /drug/guadecitabine ↗
Edges: 74

Neighbours: 22 cancers10 trials
Drawn: 32 of 32 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Guadecitabine investigated for …INVESTIGATED_FOR11 of 11
→ investigated for	Acute Myeloid Leukemiahematologic_malignancy	unknown	3	Acute Myeloid Leukemia	1	Curated	chembl	graph →
→ investigated for	Ovarian Neoplasmsubtype	unknown	2

Guadecitabine investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 36show all (up to 200)
→ investigated in trials for	Acute Myeloid Leukemiahematologic_malignancy 7 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Acute Myeloid Leukemia	7	Observed	clinicaltrials	graph →
→ investigated in trials for	Myelodysplastic Syndromehematologic_malignancy 5 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Myelodysplastic Syndrome	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Chronic Myelomonocytic Leukemia 3 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Chronic Myelomonocytic Leukemia	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Colorectal Neoplasm 3 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Colorectal Neoplasm	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Fallopian Tube Carcinoma 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Fallopian Tube Carcinoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Hepatocellular Carcinomasubtype 2 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Hepatocellular Carcinoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Lung Small Cell Carcinomasubtype 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lung Small Cell Carcinoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Ovarian Carcinoma 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Ovarian Carcinoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Primary Peritoneal Carcinoma 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Primary Peritoneal Carcinoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Acute Myeloid Leukemia, Myelodysplasia-Related 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Acute Myeloid Leukemia, Myelodysplasia-Related	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Adult Acute Myeloid Leukemia 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Adult Acute Myeloid Leukemia	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Cholangiocarcinoma 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Cholangiocarcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Clear Cell Renal Cell Carcinoma 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Clear Cell Renal Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Colorectal Adenocarcinoma 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Colorectal Adenocarcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Colorectal Carcinoma 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Colorectal Carcinoma	1	Observed	clinicaltrials	graph →

Guadecitabine investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 36show all (up to 200)

→ investigated in trials for

Acute Myeloid Leukemiahematologic_malignancy

7 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Acute Myeloid Leukemia

Observed

Guadecitabine studied in …STUDIED_INderived10 of 27show all (up to 200)
→ studied in	NCT03220477Phase 1 · active not recruiting Pembrolizumab (Immunotherapy Drug) in Combination With Guadecitabine and Mocetinostat (Epigenetic Drugs) for Patients With Advanced Lung Cancer. · 27 trials list this drug (6 active)	—	—	Malignant Lung Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT02935361Phase 1/Phase 2 · active not recruiting Guadecitabine and Atezolizumab in Treating Patients With Advanced Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia That Is Refractory or Relapsed · 27 trials list this drug (6 active)	—	—	Myelodysplastic Syndrome,Chronic Myelomonocytic Leukemia,Acute Myeloid Leukemia, Myelodysplasia-Related	1	Observed	clinicaltrials	graph →
→ studied in	NCT03257761Phase 1 · active not recruiting Guadecitabine and Durvalumab in Treating Patients With Advanced Liver, Pancreatic, Bile Duct, or Gallbladder Cancer · 27 trials list this drug (6 active)	—	—	Hepatocellular Carcinoma,Intrahepatic Cholangiocarcinoma,Malignant Gallbladder Neoplasm+2	1	Observed	clinicaltrials	graph →
→ studied in	NCT02998567Phase 1 · active not recruiting Combination Study of Guadecitabine/ASTX727 and Pembrolizumab · 27 trials list this drug (6 active)	—	—	Lung Non-Small Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT02684162Phase 2 · completed Guadecitabine and Donor Lymphocyte Infusion in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome Relapsing After Allogeneic Stem Cell Transplant · 27 trials list this drug (6 active)	—	—	Myelodysplastic Syndrome,Acute Myeloid Leukemia,Chronic Myelomonocytic Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT03206047Phase 1/Phase 2 · completed Atezolizumab, Guadecitabine, and CDX-1401 Vaccine in Treating Patients With Recurrent Ovarian, Fallopian Tube, or Primary Peritoneal Cancer · 27 trials list this drug (6 active)	—	—	Primary Peritoneal Carcinoma,Ovarian Carcinoma,Platinum-Resistant Primary Peritoneal Carcinoma+2	1	Observed	clinicaltrials	graph →
→ studied in	NCT01261312Phase 1/Phase 2 · completed SGI-110 in Participants With Myelodysplastic Syndromes (MDS) or Acute Myelogenous Leukemia (AML) · 27 trials list this drug (6 active)	—	—	Myelodysplastic Syndrome,Acute Myeloid Leukemia,Chronic Myelomonocytic Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT02920008Phase 3 · completed Phase 3 Randomized, Open-Label Study of Guadecitabine vs Treatment Choice in Previously Treated Acute Myeloid Leukemia · 27 trials list this drug (6 active)	—	—	Acute Myeloid Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT01696032Phase 2 · completed SGI-110 in Combination With Carboplatin in Ovarian Cancer · 27 trials list this drug (6 active)	—	—	Malignant Ovarian Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT01752933Phase 2 · completed SGI-110 in the Treatment of Advanced Hepatocellular Carcinoma (HCC) · 27 trials list this drug (6 active)	—	—	Hepatocellular Carcinoma	1	Observed	clinicaltrials	graph →

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