Ganitumab

monoclonal antibody

Identifier: CI-DRUG-00000269
Entity page: /drug/ganitumab ↗
Edges: 73

Neighbours: 21 cancers1 genes10 trials
Drawn: 32 of 32 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Ganitumab targets …TARGETS1 of 1
→ targets	IGF1R	—	ANTAGONIST	—	1	Curated	chembl	graph →
Ganitumab investigated for …INVESTIGATED_FOR10 of 10
→ investigated for	Breast Neoplasmcancer_family	unknown	2

Ganitumab investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 35show all (up to 200)
→ investigated in trials for	Sarcomacancer_family 6 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Sarcoma	6	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Colorectal Neoplasm 5 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Colorectal Neoplasm	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Neoplasm 5 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Neoplasm	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Pancreatic Neoplasm 5 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Pancreatic Neoplasm	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Solid Neoplasm 5 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Solid Neoplasm	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Ewing Sarcomasubtype 4 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Ewing Sarcoma	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Pancreatic Adenocarcinoma 4 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Pancreatic Adenocarcinoma	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Lung Non-Small Cell Carcinomasubtype 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lung Non-Small Cell Carcinoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Lymphoma 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lymphoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Breast Neoplasm 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Breast Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Neuroendocrine Tumor 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Neuroendocrine Tumor	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Ovarian Neoplasmsubtype 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Ovarian Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Adult Solid Neoplasm 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Adult Solid Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Alveolar Rhabdomyosarcoma 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Alveolar Rhabdomyosarcoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Askin Tumor 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Askin Tumor	1	Observed	clinicaltrials	graph →

Ganitumab investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 35show all (up to 200)

→ investigated in trials for

Sarcomacancer_family

6 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Sarcoma

Observed

Ganitumab studied in …STUDIED_INderived10 of 27show all (up to 200)
→ studied in	NCT04199026NA · recruiting Implantable Microdevice for the Delivery of Drugs and Their Effect on Tumors in Patients With Metastatic or Recurrent Sarcoma · 27 trials list this drug (2 active)	—	—	Sarcoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT02306161Phase 3 · active not recruiting Combination Chemotherapy With or Without Ganitumab in Treating Patients With Newly Diagnosed Metastatic Ewing Sarcoma · 27 trials list this drug (2 active)	—	—	Ewing Sarcoma,Peripheral Primitive Neuroectodermal Tumor of Bone,Peripheral Primitive Neuroectodermal Tumor of Soft Tissues	1	Observed	clinicaltrials	graph →
→ studied in	NCT01318642Phase 2 · terminated Ganitumab in Locally Advanced Unresectable Adenocarcinoma of the Pancreas · 27 trials list this drug (2 active)	—	—	Pancreatic Adenocarcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT00630552Phase 1/Phase 2 · completed QUILT-2.019: A Study of AMG 655 or AMG 479 in Combination With Gemcitabine for Treatment of Metastatic Pancreatic Cancer · 27 trials list this drug (2 active)	—	—	Malignant Pancreatic Neoplasm,Pancreatic Adenocarcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT00807612Phase 1/Phase 2 · terminated QUILT-2.017: Phase 1b/2 Study of AMG 479 in Combination With Paclitaxel and Carboplatin for 1st Line Treatment of Advanced Squamous Non-Small Cell Lung Cancer · 27 trials list this drug (2 active)	—	—	not mapped	1	Observed	clinicaltrials	graph →
→ studied in	NCT00626106Phase 2 · completed QUILT-2.015: A Study of AMG 479 With Exemestane or Fulvestrant in Postmenopausal Women With Hormone Receptor Positive Locally Advanced or Metastatic Breast Cancer · 27 trials list this drug (2 active)	—	—	Breast Neoplasm,Malignant Neoplasm,Malignant Breast Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT00791154Phase 1/Phase 2 · terminated QUILT-2.013: First-Line Treatment for Extensive Stage Small Cell Lung Cancer · 27 trials list this drug (2 active)	—	—	Solid Neoplasm,Malignant Lung Neoplasm,Lung Small Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT00819169Phase 1/Phase 2 · terminated QUILT-3.026: AMG 655 in Combination With AMG 479 in Advanced, Refractory Solid Tumors · 27 trials list this drug (2 active)	—	—	Malignant Neoplasm,Solid Neoplasm,Sarcoma+2	1	Observed	clinicaltrials	graph →
→ studied in	NCT00788957Phase 1/Phase 2 · completed Panitumumab Combination Study With Rilotumumab or Ganitumab in Wild-type Kirsten Rat Sarcoma Virus Oncogene Homolog (KRAS) Metastatic Colorectal Cancer (mCRC) · 27 trials list this drug (2 active)	—	—	Malignant Digestive System Neoplasm,Malignant Colorectal Neoplasm,Malignant Colon Neoplasm+1	1	Observed	clinicaltrials	graph →
→ studied in	NCT04129151Phase 2 · terminated Palbociclib + Ganitumab In Ewing Sarcoma · 27 trials list this drug (2 active)	—	—	Sarcoma,Ewing Sarcoma	1	Observed	clinicaltrials	graph →

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