FOLFOX Regimen

Identifier: CI-DRUG-00000240
Entity page: /drug/folfox-regimen ↗
Edges: 216

Neighbours: 15 cancers1 variants10 trials
Drawn: 26 of 26 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
FOLFOX Regimen predicts response to …PREDICTS_RESPONSE_TO1 of 1
← predicts response to	GSTP1 I105VSNV	sensitivity	B	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
FOLFOX Regimen investigated for …INVESTIGATED_FOR1 of 1
→ investigated for

FOLFOX Regimen investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 51show all (up to 200)
→ investigated in trials for	Malignant Colorectal Neoplasmsubtype 73 trials (15 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Colorectal Neoplasm	73	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Gastric Neoplasm 12 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Gastric Neoplasm	12	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Rectal Neoplasm 12 trials (6 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Rectal Neoplasm	12	Observed	clinicaltrials	graph →
→ investigated in trials for	Colorectal Neoplasm 11 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Colorectal Neoplasm	11	Observed	clinicaltrials	graph →
→ investigated in trials for	Colorectal Carcinoma 7 trials (5 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Colorectal Carcinoma	7	Observed	clinicaltrials	graph →
→ investigated in trials for	Hepatocellular Carcinoma 7 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Hepatocellular Carcinoma	7	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Colon Neoplasm 6 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Colon Neoplasm	6	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Neoplasm 6 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Neoplasm	6	Observed	clinicaltrials	graph →
→ investigated in trials for	Solid Neoplasm 5 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Solid Neoplasm	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Esophageal Adenocarcinoma 4 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Esophageal Adenocarcinoma	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Gastric Neoplasm 4 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Gastric Neoplasm	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Intrahepatic Cholangiocarcinoma 4 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Intrahepatic Cholangiocarcinoma	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Pancreatic Neoplasm 4 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Pancreatic Neoplasm	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Rectal Adenocarcinoma 4 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Rectal Adenocarcinoma	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Gastroesophageal Junction Adenocarcinoma 3 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Gastroesophageal Junction Adenocarcinoma	3	Observed	clinicaltrials	graph →

FOLFOX Regimen investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 51show all (up to 200)

→ investigated in trials for

Malignant Colorectal Neoplasmsubtype

73 trials (15 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Malignant Colorectal Neoplasm

Observed

FOLFOX Regimen studied in …STUDIED_INderived10 of 163show all (up to 200)
→ studied in	NCT05482893Phase 1/Phase 2 · recruiting Spevatamig (PT886) as Monotherapy or in Combination With Chemo and/or Targeted Therapy and/or ICI, for the Treatment of Patients With Advanced Gastrointestinal Cancers, Including Gastric, Gastroesophageal Junction, Pancreatic Ductal or Biliary Tract Carcinomas (the TWINPEAK Study) · 163 trials list this drug (53 active)	—	—	Malignant Biliary Tract Neoplasm,Malignant Colorectal Neoplasm,Pancreatic Ductal Adenocarcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT05712356Phase 2 · completed A Study of LSTA1 When Added to Standard of Care Versus Standard of Care Alone in Patients With Advanced Solid Tumors · 163 trials list this drug (53 active)	—	—	Intrahepatic Cholangiocarcinoma,Malignant Bile Duct Neoplasm,Malignant Gallbladder Neoplasm+2	1	Observed	clinicaltrials	graph →
→ studied in	NCT06663319Phase 1 · recruiting A Study of JNJ-89402638 for Metastatic Colorectal and Gastric Cancers · 163 trials list this drug (53 active)	—	—	Digestive System Neoplasm,Colorectal Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT07221357Phase 2/Phase 3 · recruiting A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal Cancer · 163 trials list this drug (53 active)	—	—	Colorectal Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT07284849Phase 3 · recruiting A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer · 163 trials list this drug (53 active)	—	—	Colorectal Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT04929223Phase 1 · recruiting A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC) · 163 trials list this drug (53 active)	—	—	Malignant Colorectal Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT06625775Phase 1 · recruiting Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors · 163 trials list this drug (53 active)	—	—	Adult Solid Neoplasm,Malignant Breast Neoplasm,Malignant Lung Neoplasm+1	1	Observed	clinicaltrials	graph →
→ studied in	NCT07221149Phase 2/Phase 3 · recruiting A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Nivolumab in Combination With Chemotherapy in Participants With Previously Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma (ROSETTA Gastric-204) · 163 trials list this drug (53 active)	—	—	not mapped	1	Observed	clinicaltrials	graph →
→ studied in	NCT06529718Phase 2 · recruiting Testing Ivonescimab Versus FOLFOX in Advanced Biliary Tract Cancer Patients · 163 trials list this drug (53 active)	—	—	Malignant Biliary Tract Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT07603375Phase 2 · not yet recruiting Upfront Chemotherapy With Radiation Therapy (CRT) Followed by Chemotherapy in Localized Esophageal Adenocarcinoma · 163 trials list this drug (53 active)	—	—	Esophageal Adenocarcinoma	1	Observed	clinicaltrials	graph →

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