Exemestane

small molecule

Identifier: CI-DRUG-00000228
Entity page: /drug/exemestane ↗
Edges: 276

Neighbours: 23 cancers1 genes1 variants10 trials9 approvals
Drawn: 44 of 44 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Exemestane approved for …APPROVED_FOR10 of 9
→ approved for	Malignant Breast Neoplasmcancer_family	supports	FDA ORIG	Malignant Breast Neoplasm	1	Regulatory	openfda	graph →
→ approved for	FDA · US · 2016Efficacy supplement 2016-07-25 (see label) FDA (US) · approved · 2016-07-25 · Efficacy supplement 2016-07-25 (see label)

Exemestane predicts response to …PREDICTS_RESPONSE_TO1 of 1
← predicts response to	IGF1R Overexpressionexpression	sensitivity	B	Malignant Breast Neoplasm	1	Curated	civic	graph →

Exemestane predicts response to …PREDICTS_RESPONSE_TO1 of 1

← predicts response to

IGF1R Overexpressionexpression

sensitivity

Malignant Breast Neoplasm

Curated

Exemestane investigated for …INVESTIGATED_FOR12 of 12
→ investigated for	Malignant Breast Neoplasmcancer_family	supports	B	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ investigated for	Neoplasmcancer_family	unknown	4	Neoplasm	1	Curated	chembl	graph →
→ investigated for	Breast Neoplasmcancer_family	unknown	4	Breast Neoplasm	1	Curated	chembl	graph →
→ investigated for	Ovarian Neoplasmsubtype	unknown	3	Ovarian Neoplasm	1	Curated	chembl	graph →
→ investigated for	Intraductal Carcinomahistology	unknown	3	Intraductal Carcinoma	1	Curated	chembl	graph →
→ investigated for	Granulosa Cell Tumorsubtype	unknown	2	Granulosa Cell Tumor	1	Curated	chembl	graph →
→ investigated for	Endometrial Neoplasmsubtype	unknown	2	Endometrial Neoplasm	1	Curated	chembl	graph →
→ investigated for	Triple-Negative Breast Carcinomamolecular_subtype	unknown	2	Triple-Negative Breast Carcinoma	1	Curated	chembl	graph →
→ investigated for	Breast Carcinoma In Situsubtype	unknown	2	Breast Carcinoma In Situ	1	Curated	chembl	graph →
→ investigated for	Lung Non-Small Cell Carcinomasubtype	unknown	2	Lung Non-Small Cell Carcinoma	1	Curated	chembl	graph →
→ investigated for	Lung Neoplasmcancer_family	unknown	1	Lung Neoplasm	1	Curated	chembl	graph →
→ investigated for	Lymphomacancer_family	unknown	1	Lymphoma	1	Curated	chembl	graph →

Exemestane investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 41show all (up to 200)
→ investigated in trials for	Malignant Breast Neoplasmcancer_family 125 trials (22 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Breast Neoplasm	125	Observed	clinicaltrials	graph →
→ investigated in trials for	Breast Neoplasmcancer_family 47 trials (12 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Breast Neoplasm	47	Observed	clinicaltrials	graph →
→ investigated in trials for	Breast Carcinoma 10 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Breast Carcinoma	10	Observed	clinicaltrials	graph →
→ investigated in trials for	HER2-Negative Breast Carcinoma 4 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	HER2-Negative Breast Carcinoma	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Invasive Breast Carcinoma 4 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Invasive Breast Carcinoma	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Lung Non-Small Cell Carcinomasubtype 3 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lung Non-Small Cell Carcinoma	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Male Breast Carcinoma 3 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Male Breast Carcinoma	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Ovarian Neoplasm 3 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Ovarian Neoplasm	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Neoplasmcancer_family 3 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Neoplasm	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Breast Adenocarcinoma 2 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Breast Adenocarcinoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Breast Ductal Carcinoma In Situ 2 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Breast Ductal Carcinoma In Situ	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Estrogen Receptor-Positive Breast Carcinoma 2 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Estrogen Receptor-Positive Breast Carcinoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Neoplasm 2 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Prostate Neoplasm 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Prostate Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Renal Cell Carcinoma 2 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Renal Cell Carcinoma	2	Observed	clinicaltrials	graph →

Exemestane studied in …STUDIED_INderived10 of 212show all (up to 200)
→ studied in	NCT06075953Phase 2 · recruiting DCIS: RECAST Trial Ductal Carcinoma In Situ: Re-Evaluating Conditions for Active Surveillance Suitability as Treatment · 212 trials list this drug (42 active)	—	—	Intraductal Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07391774Phase 3 · recruiting Testing Whether Hormone Therapy With Ribociclib is as Effective as Chemotherapy Followed by Hormone Therapy With Ribociclib for the Treatment of High Anatomic Stage Breast Cancer With Low Recurrence Risk, The RxFINE-Low Trial · 212 trials list this drug (42 active)	—	—	HER2-Negative Breast Carcinoma,Estrogen Receptor-Positive Breast Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT02188745Phase 2 · completed ER Reactivation Therapy for Breast Cancer · 212 trials list this drug (42 active)	—	—	Malignant Breast Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT06979596Phase 2 · recruiting A Study of MK-5684 in People With Certain Solid Tumors (MK-5684-015/OMAHA-015) · 212 trials list this drug (42 active)	—	—	Malignant Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT06179303Phase 2 · recruiting Functional Imaging in Prediction of Response to Abemaciclib for Advanced Hormone Receptor-Positive, HER2-Negative Breast Cancer · 212 trials list this drug (42 active)	—	—	HER2-Negative Breast Carcinoma,Hormone Receptor-Positive Breast Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT05827081Phase 3 · recruiting Phase IIIb Study of Ribociclib + ET in Early Breast Cancer · 212 trials list this drug (42 active)	—	—	not mapped	1	Observed	clinicaltrials	graph →
→ studied in	NCT07174336Phase 3 · recruiting A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA) · 212 trials list this drug (42 active)	—	—	Breast Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT05512364Phase 3 · recruiting Elacestrant for Treating ER+/HER2- Breast Cancer Patients With ctDNA Relapse (TREAT ctDNA) · 212 trials list this drug (42 active)	—	—	Malignant Breast Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT06492616Phase 3 · recruiting A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence · 212 trials list this drug (42 active)	—	—	Malignant Breast Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT00310180Phase 3 · active not recruiting Hormone Therapy With or Without Combination Chemotherapy in Treating Women Who Have Undergone Surgery for Node-Negative Breast Cancer (The TAILORx Trial) · 212 trials list this drug (42 active)	—	—	Malignant Breast Neoplasm,Breast Adenocarcinoma	1	Observed	clinicaltrials	graph →

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