Erlotinib Hydrochloride

small molecule

Identifier: CI-DRUG-00000224
Entity page: /drug/erlotinib-hydrochloride ↗
Edges: 396

Neighbours: 28 cancers1 genes10 trials1 approvals
Drawn: 40 of 40 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Erlotinib Hydrochloride approved for …APPROVED_FOR3 of 2
→ approved for	Lung Non-Small Cell Carcinomasubtype	supports	FDA ORIG	Lung Non-Small Cell Carcinoma	1	Regulatory	openfda	graph →
→ approved for	Malignant Pancreatic Neoplasmcancer	supports

Erlotinib Hydrochloride targets …TARGETS1 of 1
→ targets	EGFR	—	INHIBITOR	—	1	Curated	chembl	graph →

Erlotinib Hydrochloride targets …TARGETS1 of 1

→ targets

EGFR

—

INHIBITOR

—

Curated

Erlotinib Hydrochloride investigated for …INVESTIGATED_FOR15 of 56show all (up to 200)
→ investigated for	Pancreatic Neoplasmsubtype	unknown	4	Pancreatic Neoplasm	1	Curated	chembl	graph →
→ investigated for	Lung Non-Small Cell Carcinomasubtype	unknown	4	Lung Non-Small Cell Carcinoma	1	Curated	chembl	graph →
→ investigated for	Lung Neoplasmcancer_family	unknown	3	Lung Neoplasm	1	Curated	chembl	graph →
→ investigated for	Peritoneal Neoplasmcancer_family	unknown	3	Peritoneal Neoplasm	1	Curated	chembl	graph →
→ investigated for	Fallopian Tube Neoplasmsubtype	unknown	3	Fallopian Tube Neoplasm	1	Curated	chembl	graph →
→ investigated for	Colorectal Neoplasmsubtype	unknown	3	Colorectal Neoplasm	1	Curated	chembl	graph →
→ investigated for	Lung Adenocarcinomasubtype	unknown	3	Lung Adenocarcinoma	1	Curated	chembl	graph →
→ investigated for	Ovarian Neoplasmsubtype	unknown	3	Ovarian Neoplasm	1	Curated	chembl	graph →
→ investigated for	Esophageal Neoplasmcancer_family	unknown	3	Esophageal Neoplasm	1	Curated	chembl	graph →
→ investigated for	Hepatocellular Carcinomasubtype	unknown	3	Hepatocellular Carcinoma	1	Curated	chembl	graph →
→ investigated for	Head and Neck Neoplasmcancer_family	unknown	3	Head and Neck Neoplasm	1	Curated	chembl	graph →
→ investigated for	Large Cell Carcinomahistology	unknown	3	Large Cell Carcinoma	1	Curated	chembl	graph →
→ investigated for	Oral Cavity Neoplasmsubtype	unknown	3	Oral Cavity Neoplasm	1	Curated	chembl	graph →
→ investigated for	Neoplasmcancer_family	unknown	3	Neoplasm	1	Curated	chembl	graph →
→ investigated for	Squamous Cell Carcinomahistology	unknown	3	Squamous Cell Carcinoma	1	Curated	chembl	graph →

Erlotinib Hydrochloride investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 153show all (up to 200)
→ investigated in trials for	Lung Non-Small Cell Carcinomasubtype 36 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lung Non-Small Cell Carcinoma	36	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Lung Neoplasm 25 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Lung Neoplasm	25	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Pancreatic Neoplasmcancer 21 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Pancreatic Neoplasm	21	Observed	clinicaltrials	graph →
→ investigated in trials for	Oropharyngeal Squamous Cell Carcinoma 13 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Oropharyngeal Squamous Cell Carcinoma	13	Observed	clinicaltrials	graph →
→ investigated in trials for	Hypopharyngeal Squamous Cell Carcinoma 12 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Hypopharyngeal Squamous Cell Carcinoma	12	Observed	clinicaltrials	graph →
→ investigated in trials for	Laryngeal Squamous Cell Carcinoma 12 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Laryngeal Squamous Cell Carcinoma	12	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Breast Neoplasm 11 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Breast Neoplasm	11	Observed	clinicaltrials	graph →
→ investigated in trials for	Adult Solid Neoplasm 10 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Adult Solid Neoplasm	10	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Head and Neck Neoplasm 8 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Head and Neck Neoplasm	8	Observed	clinicaltrials	graph →
→ investigated in trials for	Laryngeal Verrucous Carcinoma 7 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Laryngeal Verrucous Carcinoma	7	Observed	clinicaltrials	graph →
→ investigated in trials for	Lung Adenocarcinomasubtype 7 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lung Adenocarcinoma	7	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Esophageal Neoplasm 7 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Esophageal Neoplasm	7	Observed	clinicaltrials	graph →
→ investigated in trials for	Oral Cavity Verrucous Carcinoma 7 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Oral Cavity Verrucous Carcinoma	7	Observed	clinicaltrials	graph →
→ investigated in trials for	Adult Brain Neoplasm 6 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Adult Brain Neoplasm	6	Observed	clinicaltrials	graph →
→ investigated in trials for	Adult Giant Cell Glioblastoma 6 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Adult Giant Cell Glioblastoma	6	Observed	clinicaltrials	graph →

Erlotinib Hydrochloride studied in …STUDIED_INderived10 of 184show all (up to 200)
→ studied in	NCT01660971Phase 1 · active not recruiting Gemcitabine Hydrochloride, Dasatinib, and Erlotinib Hydrochloride in Treating Patients With Pancreatic Cancer That Is Metastatic or Cannot Be Removed by Surgery · 184 trials list this drug (8 active)	—	—	Pancreatic Carcinoma,Pancreatic Adenocarcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT01708954Phase 2 · active not recruiting Erlotinib Hydrochloride and Cabozantinib-s-Malate Alone or in Combination as Second or Third Line Therapy in Treating Patients With Stage IV Non-small Cell Lung Cancer · 184 trials list this drug (8 active)	—	—	Lung Non-Small Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT00878163Phase 1 · active not recruiting GDC-0449 and Erlotinib Hydrochloride With or Without Gemcitabine Hydrochloride in Treating Patients With Metastatic Pancreatic Cancer or Solid Tumors That Cannot Be Removed by Surgery · 184 trials list this drug (8 active)	—	—	Adult Solid Neoplasm,Pancreatic Neoplasm,Pancreatic Carcinoma+2	1	Observed	clinicaltrials	graph →
→ studied in	NCT00045201Phase 1 · active not recruiting Erlotinib Hydrochloride and Irinotecan Hydrochloride in Treating Patients With Advanced Solid Tumors · 184 trials list this drug (8 active)	—	—	Adult Solid Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT00076310Phase 2 · completed OSI-774/Cisplatin/Taxotere in Head & Neck Squamous Cell Cancer · 184 trials list this drug (8 active)	—	—	Malignant Head and Neck Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT02193282Phase 3 · active not recruiting Erlotinib Hydrochloride in Treating Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been Completely Removed by Surgery (An ALCHEMIST Treatment Trial) · 184 trials list this drug (8 active)	—	—	Lung Non-Small Cell Carcinoma,Lung Non-Squamous Non-Small Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT04172779Phase 2 · not yet recruiting Erlotinib for Hepatocellular Carcinoma Chemoprevention · 184 trials list this drug (8 active)	—	—	not mapped	1	Observed	clinicaltrials	graph →
→ studied in	NCT03137771Phase 2 · active not recruiting Maintenance Chemotherapy With or Without Local Consolidative Therapy in Treating Patients With Stage IV Non-small Cell Lung Cancer · 184 trials list this drug (8 active)	—	—	Lung Non-Small Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06997068Phase 2 · recruiting Methotrexate, Erlotinib, and Celecoxib for the Treatment of Recurrent/Metastatic Head and Neck Cancer in a Rural Midwest United States Population · 184 trials list this drug (8 active)	—	—	Malignant Head and Neck Neoplasm,Malignant Lip and Oral Cavity Neoplasm,Malignant Laryngeal Neoplasm+2	1	Observed	clinicaltrials	graph →
→ studied in	NCT00885066Phase 1 · completed Gemcitabine, Capecitabine, and Erlotinib in Treating Patients With Advanced Pancreatic Cancer · 184 trials list this drug (8 active)	—	—	Malignant Pancreatic Neoplasm	1	Observed	clinicaltrials	graph →

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