Pleural Mesothelial Neoplasm

cancer family

Identifier: CI-CAN-00000322
Entity page: /cancer/pleural-mesothelial-neoplasm ↗
Edges: 209

Neighbours: 2 genes40 drugs10 trials
Drawn: 52 of 52 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Pleural Mesothelial Neoplasm approved for …APPROVED_FORderived10 of 10
← approved for	Pemetrexedsmall molecule FDA (US) · approved · 2024-06-28 · initial treatment, in combination with cisplatin, of patients with malignant pleural mesothelioma whose disease is unresectable or who are …	—	approved	Pleural Malignant Mesothelioma	1	Regulatory	openfda	graph →
← approved for	Pemetrexed

Pleural Mesothelial Neoplasm altered in cohorts of …ALTERED_INderived2 of 2
← altered in cohorts of	BAP1 22 / 78 cases (28 %) · ssm · plmeso_tcga_gdc	—	—	Pleural Mesothelial Neoplasm	1	Observed	cbioportal	graph →
← altered in cohorts of	NF2 20 / 86 cases (23 %) · ssm · meso_tcga_pan_can_atlas_2018	—	—	Pleural Mesothelial Neoplasm	1	Observed	cbioportal	graph →

Pleural Mesothelial Neoplasm altered in cohorts of …ALTERED_INderived2 of 2

← altered in cohorts of

BAP1

22 / 78 cases (28 %) · ssm · plmeso_tcga_gdc

—

Pleural Mesothelial Neoplasm

Observed

Pleural Mesothelial Neoplasm investigated in trials for …INVESTIGATED_IN_TRIALSderived40 of 40show fewer
→ investigated in trials for	Cisplatinsmall molecule 20 trials (5 active) · roll-up of the cancer and its descendants	—	—	Pleural Mesothelial Neoplasm	20	Observed	clinicaltrials	graph →
→ investigated in trials for	Pemetrexedsmall molecule 16 trials (6 active) · roll-up of the cancer and its descendants	—	—	Pleural Mesothelial Neoplasm	16	Observed	clinicaltrials	graph →
→ investigated in trials for	Pembrolizumabmonoclonal antibody 12 trials (4 active) · roll-up of the cancer and its descendants	—	—	Pleural Mesothelial Neoplasm	12	Observed	clinicaltrials	graph →
→ investigated in trials for	Gemcitabinesmall molecule 8 trials (2 active) · roll-up of the cancer and its descendants	—	—	Pleural Mesothelial Neoplasm	8	Observed	clinicaltrials	graph →
→ investigated in trials for	Nivolumabmonoclonal antibody 8 trials (5 active) · roll-up of the cancer and its descendants	—	—	Pleural Mesothelial Neoplasm	8	Observed	clinicaltrials	graph →
→ investigated in trials for	Atezolizumabmonoclonal antibody 5 trials (3 active) · roll-up of the cancer and its descendants	—	—	Pleural Mesothelial Neoplasm	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Cyclophosphamidesmall molecule 4 trials (1 active) · roll-up of the cancer and its descendants	—	—	Pleural Mesothelial Neoplasm	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Ipilimumabmonoclonal antibody 3 trials (3 active) · roll-up of the cancer and its descendants	—	—	Pleural Mesothelial Neoplasm	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Aldesleukinother 2 trials (0 active) · roll-up of the cancer and its descendants	—	—	Pleural Mesothelial Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Carboplatinsmall molecule 2 trials (1 active) · roll-up of the cancer and its descendants	—	—	Pleural Mesothelial Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Chemotherapy 2 trials (0 active) · roll-up of the cancer and its descendants	—	—	Pleural Mesothelial Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Durvalumabmonoclonal antibody 2 trials (0 active) · roll-up of the cancer and its descendants	—	—	Pleural Mesothelial Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Nintedanibsmall molecule 2 trials (0 active) · roll-up of the cancer and its descendants	—	—	Pleural Mesothelial Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Vinorelbinesmall molecule 2 trials (1 active) · roll-up of the cancer and its descendants	—	—	Pleural Mesothelial Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Adjuvant Chemotherapy 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Pleural Mesothelial Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Axitinibsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Pleural Mesothelial Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Bevacizumabmonoclonal antibody 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	Pleural Mesothelial Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Cediranibsmall molecule 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	Pleural Mesothelial Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Celecoxibsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Pleural Mesothelial Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Cixutumumabmonoclonal antibody 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Pleural Mesothelial Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Dasatinibsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Pleural Mesothelial Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Docetaxelsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Pleural Mesothelial Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Dovitinibsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Pleural Mesothelial Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Doxorubicinsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Pleural Mesothelial Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Elimusertibsmall molecule 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	Pleural Mesothelial Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Everolimussmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Pleural Mesothelial Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Fludarabinesmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Pleural Mesothelial Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Ipilimumab/Nivolumab Regimen 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Pleural Mesothelial Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Lenvatinibsmall molecule 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	Pleural Mesothelial Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Leucovorinsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Pleural Mesothelial Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Lifileucelcell therapy 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Pleural Mesothelial Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Lurbinectedinsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Pleural Mesothelial Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Methotrexatesmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Pleural Mesothelial Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Nadofaragene Firadenovecgene therapy 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Pleural Mesothelial Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Osimertinibsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Pleural Mesothelial Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Paclitaxelsmall molecule 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	Pleural Mesothelial Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Pegargiminaseother 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Pleural Mesothelial Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Toripalimabmonoclonal antibody 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Pleural Mesothelial Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Trabectedinsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Pleural Mesothelial Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Vorinostatsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Pleural Mesothelial Neoplasm	1	Observed	clinicaltrials	graph →

Pleural Mesothelial Neoplasm studied in …STUDIED_INderived10 of 157show all (up to 200)
→ studied in	NCT07277413Phase 1 · recruiting A Study of IDE892 as Monotherapy and Combination in MTAP-deleted Advanced Solid Tumors · condition mapped ALIAS · 157 trials mapped (39 active)	—	—	Pleural Mesothelial Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT06037941NA · recruiting Using E-Nose Technology to Measure Response to Treatment in People With Malignant Pleural Mesothelioma · condition mapped ALIAS · 157 trials mapped (39 active)	—	—	Pleural Malignant Mesothelioma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07824986Phase 3 · not yet recruiting A Phase 3 Trial in Advanced Epithelioid Mesothelioma · condition mapped ALIAS · 157 trials mapped (39 active)	—	—	Pleural Mesothelial Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT06318286Phase 2 · active not recruiting Study of Pembrolizumab Plus Chemotherapy With Lenvatinib for Malignant Pleural Mesothelioma · condition mapped ALIAS · 157 trials mapped (39 active)	—	—	Pleural Malignant Mesothelioma	1	Observed	clinicaltrials	graph →
→ studied in	NCT03074513Phase 2 · active not recruiting Atezolizumab and Bevacizumab in Treating Patients With Rare Solid Tumors · condition mapped CURATED_BROADER · 157 trials mapped (39 active)	—	—	Pleural Malignant Mesothelioma	1	Observed	clinicaltrials	graph →
→ studied in	NCT04162015Phase 1 · active not recruiting A Study of Nivolumab and Chemotherapy Followed by Surgery for Mesothelioma · condition mapped ALIAS · 157 trials mapped (39 active)	—	—	Pleural Malignant Mesothelioma	1	Observed	clinicaltrials	graph →
→ studied in	NCT01064648Phase 1/Phase 2 · active not recruiting Pemetrexed Disodium and Cisplatin With or Without Cediranib Maleate in Treating Patients With Malignant Pleural Mesothelioma · condition mapped ONTOLOGY_EXACT · 157 trials mapped (39 active)	—	—	Pleural Malignant Mesothelioma	1	Observed	clinicaltrials	graph →
→ studied in	NCT04106973terminated Mesothelioma Early Detection by VOCs · condition mapped ALIAS · 157 trials mapped (39 active)	—	—	Pleural Mesothelial Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT05647265Phase 2 · recruiting Testing the Addition of Immunotherapy Before Surgery for Patients With Sarcomatoid Mesothelioma · condition mapped ONTOLOGY_EXACT · 157 trials mapped (39 active)	—	—	Pleural Biphasic Mesothelioma	1	Observed	clinicaltrials	graph →
→ studied in	NCT03228537Phase 1 · active not recruiting Atezolizumab, Pemetrexed Disodium, Cisplatin, and Surgery With or Without Radiation Therapy in Treating Patients With Stage I-III Pleural Malignant Mesothelioma · condition mapped CURATED_BROADER · 157 trials mapped (39 active)	—	—	Pleural Diffuse Malignant Mesothelioma	1	Observed	clinicaltrials	graph →

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