Malignant Pleural Neoplasm

subtype

Identifier: CI-CAN-00001168
Entity page: /cancer/malignant-pleural-neoplasm ↗
Edges: 168

Neighbours: 34 drugs10 trials
Drawn: 44 of 44 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Malignant Pleural Neoplasm approved for …APPROVED_FORderived10 of 10
← approved for	Pemetrexedsmall molecule FDA (US) · approved · 2024-06-28 · initial treatment, in combination with cisplatin, of patients with malignant pleural mesothelioma whose disease is unresectable or who are …	—	approved	Pleural Malignant Mesothelioma	1	Regulatory	openfda	graph →
← approved for	Pemetrexed

Malignant Pleural Neoplasm investigated in trials for …INVESTIGATED_IN_TRIALSderived34 of 34show fewer
→ investigated in trials for	Cisplatinsmall molecule 17 trials (4 active) · roll-up of the cancer and its descendants	—	—	Malignant Pleural Neoplasm	17	Observed	clinicaltrials	graph →
→ investigated in trials for	Pemetrexedsmall molecule 13 trials (5 active) · roll-up of the cancer and its descendants	—	—	Malignant Pleural Neoplasm	13	Observed	clinicaltrials	graph →
→ investigated in trials for	Pembrolizumabmonoclonal antibody 8 trials (3 active) · roll-up of the cancer and its descendants	—	—	Malignant Pleural Neoplasm	8	Observed	clinicaltrials	graph →
→ investigated in trials for	Gemcitabinesmall molecule 7 trials (1 active) · roll-up of the cancer and its descendants	—	—	Malignant Pleural Neoplasm	7	Observed	clinicaltrials	graph →
→ investigated in trials for	Atezolizumabmonoclonal antibody 5 trials (3 active) · roll-up of the cancer and its descendants	—	—	Malignant Pleural Neoplasm	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Nivolumabmonoclonal antibody 5 trials (3 active) · roll-up of the cancer and its descendants	—	—	Malignant Pleural Neoplasm	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Cyclophosphamidesmall molecule 3 trials (1 active) · roll-up of the cancer and its descendants	—	—	Malignant Pleural Neoplasm	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Chemotherapy 2 trials (0 active) · roll-up of the cancer and its descendants	—	—	Malignant Pleural Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Nintedanibsmall molecule 2 trials (0 active) · roll-up of the cancer and its descendants	—	—	Malignant Pleural Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Adjuvant Chemotherapy 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Malignant Pleural Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Aldesleukinother 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Malignant Pleural Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Axitinibsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Malignant Pleural Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Bevacizumabmonoclonal antibody 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	Malignant Pleural Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Carboplatinsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Malignant Pleural Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Cediranibsmall molecule 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	Malignant Pleural Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Celecoxibsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Malignant Pleural Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Dasatinibsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Malignant Pleural Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Dovitinibsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Malignant Pleural Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Durvalumabmonoclonal antibody 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Malignant Pleural Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Elimusertibsmall molecule 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	Malignant Pleural Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Everolimussmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Malignant Pleural Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Ipilimumabmonoclonal antibody 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	Malignant Pleural Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Ipilimumab/Nivolumab Regimen 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Malignant Pleural Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Lenvatinibsmall molecule 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	Malignant Pleural Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Lurbinectedinsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Malignant Pleural Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Methotrexatesmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Malignant Pleural Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Nadofaragene Firadenovecgene therapy 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Malignant Pleural Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Osimertinibsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Malignant Pleural Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Paclitaxelsmall molecule 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	Malignant Pleural Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Pegargiminaseother 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Malignant Pleural Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Toripalimabmonoclonal antibody 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Malignant Pleural Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Trabectedinsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Malignant Pleural Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Vinorelbinesmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Malignant Pleural Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Vorinostatsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Malignant Pleural Neoplasm	1	Observed	clinicaltrials	graph →

Malignant Pleural Neoplasm investigated in trials for …INVESTIGATED_IN_TRIALSderived34 of 34show fewer

→ investigated in trials for

Cisplatinsmall molecule

17 trials (4 active) · roll-up of the cancer and its descendants

—

Malignant Pleural Neoplasm

Observed

Malignant Pleural Neoplasm studied in …STUDIED_INderived10 of 124show all (up to 200)
→ studied in	NCT06037941NA · recruiting Using E-Nose Technology to Measure Response to Treatment in People With Malignant Pleural Mesothelioma · condition mapped ALIAS · 124 trials mapped (30 active)	—	—	Pleural Malignant Mesothelioma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06318286Phase 2 · active not recruiting Study of Pembrolizumab Plus Chemotherapy With Lenvatinib for Malignant Pleural Mesothelioma · condition mapped ALIAS · 124 trials mapped (30 active)	—	—	Pleural Malignant Mesothelioma	1	Observed	clinicaltrials	graph →
→ studied in	NCT03074513Phase 2 · active not recruiting Atezolizumab and Bevacizumab in Treating Patients With Rare Solid Tumors · condition mapped CURATED_BROADER · 124 trials mapped (30 active)	—	—	Pleural Malignant Mesothelioma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06674811recruiting Biomarkers of Resiliency In Childhood Cancer Surgery · condition mapped ONTOLOGY_EXACT · 124 trials mapped (30 active)	—	—	Childhood Malignant Pleural Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT04162015Phase 1 · active not recruiting A Study of Nivolumab and Chemotherapy Followed by Surgery for Mesothelioma · condition mapped ALIAS · 124 trials mapped (30 active)	—	—	Pleural Malignant Mesothelioma	1	Observed	clinicaltrials	graph →
→ studied in	NCT01064648Phase 1/Phase 2 · active not recruiting Pemetrexed Disodium and Cisplatin With or Without Cediranib Maleate in Treating Patients With Malignant Pleural Mesothelioma · condition mapped ONTOLOGY_EXACT · 124 trials mapped (30 active)	—	—	Pleural Malignant Mesothelioma	1	Observed	clinicaltrials	graph →
→ studied in	NCT05647265Phase 2 · recruiting Testing the Addition of Immunotherapy Before Surgery for Patients With Sarcomatoid Mesothelioma · condition mapped ONTOLOGY_EXACT · 124 trials mapped (30 active)	—	—	Pleural Biphasic Mesothelioma	1	Observed	clinicaltrials	graph →
→ studied in	NCT03228537Phase 1 · active not recruiting Atezolizumab, Pemetrexed Disodium, Cisplatin, and Surgery With or Without Radiation Therapy in Treating Patients With Stage I-III Pleural Malignant Mesothelioma · condition mapped CURATED_BROADER · 124 trials mapped (30 active)	—	—	Pleural Diffuse Malignant Mesothelioma	1	Observed	clinicaltrials	graph →
→ studied in	NCT02535312Phase 1/Phase 2 · active not recruiting Methoxyamine, Cisplatin, and Pemetrexed Disodium in Treating Patients With Advanced Solid Tumors or Mesothelioma That Cannot Be Removed by Surgery or Mesothelioma That Is Refractory to Pemetrexed Disodium and Cisplatin or Carboplatin · condition mapped CURATED_BROADER · 124 trials mapped (30 active)	—	—	Pleural Malignant Mesothelioma	1	Observed	clinicaltrials	graph →
→ studied in	NCT04491942Phase 1 · active not recruiting Testing the Addition of an Anti-cancer Drug, BAY 1895344, to the Usual Chemotherapy Treatment (Cisplatin, or Cisplatin and Gemcitabine) for Advanced Solid Tumors With Emphasis on Urothelial Cancer · condition mapped CURATED_BROADER · 124 trials mapped (30 active)	—	—	Pleural Malignant Mesothelioma	1	Observed	clinicaltrials	graph →

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