Clinical trial · Observational
Biomarkers of Resiliency In Childhood Cancer Surgery
Digital Biomarker and Omics-Based Assessment of Surgical Resiliency in Children Undergoing Solid Tumor Resection: A Pilot Feasibility Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 15, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260915-000001
Summary
Brief summary (as posted)
This observational study is to better understand how children and their families recover after the stress of major surgery for cancer so that investigators can create ways to improve resilience during recovery. The main questions it aims to answer are: 1. Can information obtained from patients and their caregivers wearing smartwatches and answering questionnaires be used to measure how patients are recovering from surgery? 2. Are there specific patterns in patients' circulating proteins and metabolites that are associated with stress after surgery? Participants, including pediatric patients undergoing surgery for cancer and their primary caregiver, will be asked to: * wear a smartwatch * complete questionnaires * allow for extra blood to be drawn for this research study when they are having their regular blood draws for clinical purposes These actions will occur at baseline prior to patients' surgery and then afterwards for up to one year. There are no changes to participants' clinical care or surgical care as a result of the study. Investigators will also collect participants' clinical information and cancer-specific outcomes. Participants will be remunerated for their time.
Conditions
Conditions (13)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Childhood Bone Sarcoma | Childhood Bone Sarcoma | ONTOLOGY_EXACT | 0.98 |
| Childhood Malignant Intestinal Neoplasm | Childhood Malignant Intestinal Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Childhood Malignant Liver Neoplasm | Childhood Malignant Liver Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Childhood Malignant Lung Neoplasm | Childhood Malignant Lung Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Childhood Malignant Ovarian Neoplasm | Childhood Malignant Ovarian Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Childhood Malignant Pleural Neoplasm | Childhood Malignant Pleural Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Childhood Neuroblastic Tumor |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Blood Draw | Other | — | UNRESOLVED |
| Clinical Data Review | Other | — | UNRESOLVED |
| Patient Report Outcomes | Other | — | UNRESOLVED |
| Wearing Smartwatch | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Patient
- description
- Children and young adults 3-18 years old who are undergoing surgical resection of an extracranial solid tumor.
- interventionNames
- Other: Wearing Smartwatch
- Other: Patient Report Outcomes
- Other: Blood Draw
- Other: Clinical Data Review
- label
- Caregiver
- description
- Primary caregiver or parent of a a child or young adults 3-18 years old who is undergoing surgical resection for an extracranial solid tumor and has agreed to participate in the study.
- interventionNames
- Other: Wearing Smartwatch
- Other: Patient Report Outcomes
Primary outcomes (1)
- measure
- Surgical resilience
- timeFrame
- 1 year
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 3 Years
- Maximum age
- 25 Years
Show eligibility criteria text
Inclusion Criteria: * 3-25 years old at enrollment * With solid tumors of the chest, abdomen, and extremities including neuroblastic tumors, sarcoma including soft tissue and bone, kidney tumors, liver tumors, ovarian tumors, lung and pleural-based tumors, and intestinal tumors -OR- * Guardian or primary caregiver of patient 3-25 years old with one of the aforementioned tumors. Exclusion Criteria: * Patients who are known to be pregnant or prisoners.
References
Publications (0)
Data not yet available