Malignant Peripheral Nerve Sheath Tumor

subtype

Identifier: CI-CAN-00001162
Entity page: /cancer/malignant-peripheral-nerve-sheath-tumor ↗
Edges: 99

Neighbours: 3 genes3 variants34 drugs10 trials
Drawn: 50 of 50 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Malignant Peripheral Nerve Sheath Tumor predicts response to …PREDICTS_RESPONSE_TO2 of 2
in context · predicts response to	PARP1 OVEREXPRESSIONexpression → predicts response to Olaparib	sensitivity	D	Malignant Peripheral Nerve Sheath Tumor	1	Curated	civic	graph →
in context · predicts response to

Malignant Peripheral Nerve Sheath Tumor diagnostic of …DIAGNOSTIC_OF1 of 1
← diagnostic of	SSX1 Fusionfusion	supports	B	Malignant Peripheral Nerve Sheath Tumor	1	Curated	civic	graph →

Malignant Peripheral Nerve Sheath Tumor diagnostic of …DIAGNOSTIC_OF1 of 1

← diagnostic of

SSX1 Fusionfusion

supports

Malignant Peripheral Nerve Sheath Tumor associated with …ASSOCIATED_WITH3 of 3
← associated with	SSX1	supports	B	Malignant Peripheral Nerve Sheath Tumor	1	Curated	civic	graph →
← associated with	PARP1	supports	D	Malignant Peripheral Nerve Sheath Tumor	1	Curated	civic	graph →
← associated with	NF1	supports	D	Malignant Peripheral Nerve Sheath Tumor	1	Curated	civic	graph →

Malignant Peripheral Nerve Sheath Tumor investigated for …INVESTIGATED_FOR2 of 2
← investigated for	Olaparibsmall_molecule	supports	D	Malignant Peripheral Nerve Sheath Tumor	1	Curated	civic	graph →
← investigated for	JQ1 Compound	supports	D	Malignant Peripheral Nerve Sheath Tumor	1	Curated	civic	graph →

Malignant Peripheral Nerve Sheath Tumor investigated in trials for …INVESTIGATED_IN_TRIALSderived32 of 32show fewer
→ investigated in trials for	Doxorubicinsmall molecule 7 trials (2 active) · roll-up of the cancer and its descendants	—	—	Malignant Peripheral Nerve Sheath Tumor	7	Observed	clinicaltrials	graph →
→ investigated in trials for	Ifosfamidesmall molecule 4 trials (2 active) · roll-up of the cancer and its descendants	—	—	Malignant Peripheral Nerve Sheath Tumor	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Pazopanibsmall molecule 4 trials (1 active) · roll-up of the cancer and its descendants	—	—	Malignant Peripheral Nerve Sheath Tumor	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Selinexorsmall molecule 4 trials (2 active) · roll-up of the cancer and its descendants	—	—	Malignant Peripheral Nerve Sheath Tumor	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Nivolumabmonoclonal antibody 3 trials (3 active) · roll-up of the cancer and its descendants	—	—	Malignant Peripheral Nerve Sheath Tumor	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Sirolimussmall molecule 3 trials (0 active) · roll-up of the cancer and its descendants	—	—	Malignant Peripheral Nerve Sheath Tumor	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Cixutumumabmonoclonal antibody 2 trials (0 active) · roll-up of the cancer and its descendants	—	—	Malignant Peripheral Nerve Sheath Tumor	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Fludarabinesmall molecule 2 trials (1 active) · roll-up of the cancer and its descendants	—	—	Malignant Peripheral Nerve Sheath Tumor	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Pembrolizumabmonoclonal antibody 2 trials (1 active) · roll-up of the cancer and its descendants	—	—	Malignant Peripheral Nerve Sheath Tumor	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Selumetinibsmall molecule 2 trials (1 active) · roll-up of the cancer and its descendants	—	—	Malignant Peripheral Nerve Sheath Tumor	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Alisertibsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Malignant Peripheral Nerve Sheath Tumor	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Bevacizumabmonoclonal antibody 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Malignant Peripheral Nerve Sheath Tumor	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Cyclophosphamidesmall molecule 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	Malignant Peripheral Nerve Sheath Tumor	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Dasatinibsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Malignant Peripheral Nerve Sheath Tumor	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Etoposidesmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Malignant Peripheral Nerve Sheath Tumor	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Everolimussmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Malignant Peripheral Nerve Sheath Tumor	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Filgrastimother 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Malignant Peripheral Nerve Sheath Tumor	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Ganetespibsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Malignant Peripheral Nerve Sheath Tumor	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Gemcitabinesmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Malignant Peripheral Nerve Sheath Tumor	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Imatinib Mesylatesmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Malignant Peripheral Nerve Sheath Tumor	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Ipilimumabmonoclonal antibody 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	Malignant Peripheral Nerve Sheath Tumor	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Ixazomibsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Malignant Peripheral Nerve Sheath Tumor	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Melphalansmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Malignant Peripheral Nerve Sheath Tumor	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Pexidartinibsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Malignant Peripheral Nerve Sheath Tumor	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Ribociclibsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Malignant Peripheral Nerve Sheath Tumor	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Romidepsinother 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Malignant Peripheral Nerve Sheath Tumor	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Sapanisertibsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Malignant Peripheral Nerve Sheath Tumor	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Sorafenib Tosylatesmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Malignant Peripheral Nerve Sheath Tumor	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Tazemetostatsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Malignant Peripheral Nerve Sheath Tumor	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Temsirolimussmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Malignant Peripheral Nerve Sheath Tumor	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Thiotepasmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Malignant Peripheral Nerve Sheath Tumor	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Vismodegibsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Malignant Peripheral Nerve Sheath Tumor	1	Observed	clinicaltrials	graph →

Malignant Peripheral Nerve Sheath Tumor studied in …STUDIED_INderived10 of 59show all (up to 200)
→ studied in	NCT00924196active not recruiting Natural History Study of Patients With Neurofibromatosis Type I · condition mapped ONTOLOGY_EXACT · 59 trials mapped (24 active)	—	—	Malignant Peripheral Nerve Sheath Tumor	1	Observed	clinicaltrials	graph →
→ studied in	NCT04222413Phase 1 · recruiting Metarrestin (ML-246) in Subjects With Metastatic Solid Tumors · condition mapped ONTOLOGY_EXACT · 59 trials mapped (24 active)	—	—	Malignant Peripheral Nerve Sheath Tumor	1	Observed	clinicaltrials	graph →
→ studied in	NCT07298083recruiting DoD Award NF230020 Identification of Metabolic Markers and Statistical Prediction of MPNST for Rapid Diagnosis and Assessment of Surgical Margins · condition mapped ALIAS · 59 trials mapped (24 active)	—	—	Malignant Peripheral Nerve Sheath Tumor	1	Observed	clinicaltrials	graph →
→ studied in	NCT05245500Phase 1 · recruiting Phase 1 Study of MRTX1719 in Solid Tumors With MTAP Deletion · condition mapped ONTOLOGY_EXACT · 59 trials mapped (24 active)	—	—	Malignant Peripheral Nerve Sheath Tumor	1	Observed	clinicaltrials	graph →
→ studied in	NCT06515860enrolling by invitation Neurofibromatosis Type 1 Tumor Early Detection Study · condition mapped ONTOLOGY_EXACT · 59 trials mapped (24 active)	—	—	Malignant Peripheral Nerve Sheath Tumor	1	Observed	clinicaltrials	graph →
→ studied in	NCT05253131Phase 2 · recruiting Trial of Selumetinib and Bromodomain Inhibitor With Durvalumab for Sarcomas · condition mapped ALIAS · 59 trials mapped (24 active)	—	—	Malignant Peripheral Nerve Sheath Tumor	1	Observed	clinicaltrials	graph →
→ studied in	NCT05642455Phase 1/Phase 2 · recruiting SPEARHEAD-3 Pediatric Study · condition mapped ONTOLOGY_EXACT · 59 trials mapped (24 active)	—	—	Malignant Peripheral Nerve Sheath Tumor	1	Observed	clinicaltrials	graph →
→ studied in	NCT07549022Phase 1/Phase 2 · recruiting Safety and Efficacy of BMS-986504 in Unresectable Malignant Peripheral Nerve Sheath Tumor · condition mapped ONTOLOGY_EXACT · 59 trials mapped (24 active)	—	—	Malignant Peripheral Nerve Sheath Tumor	1	Observed	clinicaltrials	graph →
→ studied in	NCT02211768Phase 1 · completed Transformation of Plexiform Neurofibromas to Malignant Peripheral Nerve Sheath Tumors in Neurofibromatosis Type 1 · condition mapped ALIAS · 59 trials mapped (24 active)	—	—	Malignant Peripheral Nerve Sheath Tumor	1	Observed	clinicaltrials	graph →
→ studied in	NCT07743554Phase 2 · not yet recruiting Combination of Avutometinib and Defactinib for Treatment of Relapsed, Refractory, Metastatic, or Unresectable Malignant Peripheral Nerve Sheath Tumor · condition mapped ALIAS · 59 trials mapped (24 active)	—	—	Malignant Peripheral Nerve Sheath Tumor	1	Observed	clinicaltrials	graph →

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