Malignant Histiocytic and Dendritic Cell Neoplasm

cancer family

Identifier: CI-CAN-00000237
Entity page: /cancer/malignant-histiocytic-and-dendritic-cell-neoplasm ↗
Edges: 128

Neighbours: 15 drugs10 trials
Drawn: 25 of 25 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Malignant Histiocytic and Dendritic Cell Neoplasm approved for …APPROVED_FORderived2 of 2
← approved for	Tagraxofuspother EMA (EU) · approved · 2021-01-07 · Elzonris is indicated as monotherapy for the first-line treatment of adult patients with blastic plasmacytoid dendritic cell neoplasm …	—	approved	Blastic Plasmacytoid Dendritic Cell Neoplasm	1	Regulatory	ema	graph →
← approved for

Malignant Histiocytic and Dendritic Cell Neoplasm investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 44show all (up to 200)
→ investigated in trials for	Cyclophosphamidesmall molecule 11 trials (8 active) · roll-up of the cancer and its descendants	—	—	Malignant Histiocytic and Dendritic Cell Neoplasm	11	Observed	clinicaltrials	graph →
→ investigated in trials for	Fludarabinesmall molecule 9 trials (6 active) · roll-up of the cancer and its descendants	—	—	Malignant Histiocytic and Dendritic Cell Neoplasm	9	Observed	clinicaltrials	graph →
→ investigated in trials for	Tagraxofuspother 8 trials (5 active) · roll-up of the cancer and its descendants	—	—	Malignant Histiocytic and Dendritic Cell Neoplasm	8	Observed	clinicaltrials	graph →
→ investigated in trials for	Venetoclaxsmall molecule 5 trials (3 active) · roll-up of the cancer and its descendants	—	—	Malignant Histiocytic and Dendritic Cell Neoplasm	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Methotrexatesmall molecule 4 trials (3 active) · roll-up of the cancer and its descendants	—	—	Malignant Histiocytic and Dendritic Cell Neoplasm	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Rituximabmonoclonal antibody 4 trials (4 active) · roll-up of the cancer and its descendants	—	—	Malignant Histiocytic and Dendritic Cell Neoplasm	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Dexamethasonesmall molecule 3 trials (2 active) · roll-up of the cancer and its descendants	—	—	Malignant Histiocytic and Dendritic Cell Neoplasm	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Thiotepasmall molecule 3 trials (2 active) · roll-up of the cancer and its descendants	—	—	Malignant Histiocytic and Dendritic Cell Neoplasm	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Azacitidinesmall molecule 2 trials (2 active) · roll-up of the cancer and its descendants	—	—	Malignant Histiocytic and Dendritic Cell Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Chemotherapy 2 trials (1 active) · roll-up of the cancer and its descendants	—	—	Malignant Histiocytic and Dendritic Cell Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Cytarabinesmall molecule 2 trials (2 active) · roll-up of the cancer and its descendants	—	—	Malignant Histiocytic and Dendritic Cell Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Doxorubicinsmall molecule 2 trials (2 active) · roll-up of the cancer and its descendants	—	—	Malignant Histiocytic and Dendritic Cell Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Glofitamabmonoclonal antibody 2 trials (2 active) · roll-up of the cancer and its descendants	—	—	Malignant Histiocytic and Dendritic Cell Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Prednisonesmall molecule 2 trials (2 active) · roll-up of the cancer and its descendants	—	—	Malignant Histiocytic and Dendritic Cell Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Vincristinesmall molecule 2 trials (2 active) · roll-up of the cancer and its descendants	—	—	Malignant Histiocytic and Dendritic Cell Neoplasm	2	Observed	clinicaltrials	graph →

Malignant Histiocytic and Dendritic Cell Neoplasm investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 44show all (up to 200)

→ investigated in trials for

Cyclophosphamidesmall molecule

11 trials (8 active) · roll-up of the cancer and its descendants

—

Malignant Histiocytic and Dendritic Cell Neoplasm

Observed

Malignant Histiocytic and Dendritic Cell Neoplasm studied in …STUDIED_INderived10 of 82show all (up to 200)
→ studied in	NCT03779854Phase 2 · active not recruiting Naive T Cell Depletion for Preventing Chronic Graft-versus-Host Disease in Children and Young Adults With Blood Cancers Undergoing Donor Stem Cell Transplant · condition mapped ONTOLOGY_EXACT · 82 trials mapped (55 active)	—	—	Blastic Plasmacytoid Dendritic Cell Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT07785180recruiting A Non-interventional Study of Participants With BPDCN Treated With Chemotherapy · condition mapped ONTOLOGY_EXACT · 82 trials mapped (55 active)	—	—	Blastic Plasmacytoid Dendritic Cell Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT04216524Phase 2 · recruiting Venetoclax, SL-401, and Chemotherapy for the Treatment of Blastic Plasmacytoid Dendritic Cell Neoplasm · condition mapped ONTOLOGY_EXACT · 82 trials mapped (55 active)	—	—	Blastic Plasmacytoid Dendritic Cell Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT06765876early Phase 1 · active not recruiting CART123 T Cells in Relapsed or Refractory CD123+ Hematologic Malignancies: A Dose Escalation Phase I Trial · condition mapped ONTOLOGY_EXACT · 82 trials mapped (55 active)	—	—	Blastic Plasmacytoid Dendritic Cell Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT07819396Phase 2 · not yet recruiting Depletion of CD45RA Positive Naive T Cells for the Prevention of Graft Versus Host Disease in Older Patients Undergoing Allogeneic Hematopoietic Cell Transplantation for Acute Leukemia or Myelodysplastic Syndrome · condition mapped ONTOLOGY_EXACT · 82 trials mapped (55 active)	—	—	Blastic Plasmacytoid Dendritic Cell Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT03386513Phase 1/Phase 2 · active not recruiting Study of IMGN632 in Patients With Untreated BPDCN and Relapsed/Refractory BPDCN · condition mapped ONTOLOGY_EXACT · 82 trials mapped (55 active)	—	—	Blastic Plasmacytoid Dendritic Cell Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT06690827Phase 1 · recruiting Clinical Trial of CD123-targeted CAR-NK Therapy for Relapse/Refractory AML or BPDCN · condition mapped ALIAS · 82 trials mapped (55 active)	—	—	Blastic Plasmacytoid Dendritic Cell Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT07443137Phase 1 · not yet recruiting CAR-T ceLL for Eradication of Active Residual Disease in LBCL (CLEAR-1 Study) · condition mapped ONTOLOGY_EXACT · 82 trials mapped (55 active)	—	—	Interdigitating Dendritic Cell Sarcoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT02159495Phase 1 · active not recruiting Genetically Modified T-cell Immunotherapy in Treating Patients With Relapsed/Refractory Acute Myeloid Leukemia and Persistent/Recurrent Blastic Plasmacytoid Dendritic Cell Neoplasm · condition mapped ONTOLOGY_EXACT · 82 trials mapped (55 active)	—	—	Blastic Plasmacytoid Dendritic Cell Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT07785154recruiting A Registry-study of ELZONRIS in Participants With BPDCN · condition mapped ONTOLOGY_EXACT · 82 trials mapped (55 active)	—	—	Blastic Plasmacytoid Dendritic Cell Neoplasm	1	Observed	clinicaltrials	graph →

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