Langerhans Cell Histiocytosis

Curated

civic

Langerhans Cell Histiocytosis investigated in trials for …INVESTIGATED_IN_TRIALSderived24 of 24show fewer
→ investigated in trials for	Busulfansmall molecule 2 trials (0 active) · roll-up of the cancer and its descendants	—	—	Langerhans Cell Histiocytosis	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Cyclophosphamidesmall molecule 2 trials (0 active) · roll-up of the cancer and its descendants	—	—	Langerhans Cell Histiocytosis	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Ensartinibsmall molecule 2 trials (2 active) · roll-up of the cancer and its descendants	—	—	Langerhans Cell Histiocytosis	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Erdafitinibsmall molecule 2 trials (2 active) · roll-up of the cancer and its descendants	—	—	Langerhans Cell Histiocytosis	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Fludarabinesmall molecule 2 trials (0 active) · roll-up of the cancer and its descendants	—	—	Langerhans Cell Histiocytosis	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Ivosidenibsmall molecule 2 trials (2 active) · roll-up of the cancer and its descendants	—	—	Langerhans Cell Histiocytosis	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Larotrectinibsmall molecule 2 trials (2 active) · roll-up of the cancer and its descendants	—	—	Langerhans Cell Histiocytosis	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Melphalansmall molecule 2 trials (0 active) · roll-up of the cancer and its descendants	—	—	Langerhans Cell Histiocytosis	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Olaparibsmall molecule 2 trials (1 active) · roll-up of the cancer and its descendants	—	—	Langerhans Cell Histiocytosis	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Palbociclibsmall molecule 2 trials (1 active) · roll-up of the cancer and its descendants	—	—	Langerhans Cell Histiocytosis	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Samotolisibsmall molecule 2 trials (1 active) · roll-up of the cancer and its descendants	—	—	Langerhans Cell Histiocytosis	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Selpercatinibsmall molecule 2 trials (2 active) · roll-up of the cancer and its descendants	—	—	Langerhans Cell Histiocytosis	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Tazemetostatsmall molecule 2 trials (1 active) · roll-up of the cancer and its descendants	—	—	Langerhans Cell Histiocytosis	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Tipifarnibsmall molecule 2 trials (2 active) · roll-up of the cancer and its descendants	—	—	Langerhans Cell Histiocytosis	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Vemurafenibsmall_molecule 2 trials (1 active) · roll-up of the cancer and its descendants	—	—	Langerhans Cell Histiocytosis	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Clofarabinesmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Langerhans Cell Histiocytosis	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Cobimetinibsmall molecule 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	Langerhans Cell Histiocytosis	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Dabrafenibsmall molecule 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	Langerhans Cell Histiocytosis	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Filgrastimother 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Langerhans Cell Histiocytosis	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Lenalidomidesmall molecule 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	Langerhans Cell Histiocytosis	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Rituximabmonoclonal antibody 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Langerhans Cell Histiocytosis	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Selumetinibsmall molecule 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	Langerhans Cell Histiocytosis	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Sunitinibsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Langerhans Cell Histiocytosis	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Trametinibsmall molecule 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	Langerhans Cell Histiocytosis	1	Observed	clinicaltrials	graph →

Langerhans Cell Histiocytosis investigated in trials for …INVESTIGATED_IN_TRIALSderived24 of 24show fewer

→ investigated in trials for

Busulfansmall molecule

2 trials (0 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Cyclophosphamidesmall molecule

2 trials (0 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Ensartinibsmall molecule

2 trials (2 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Erdafitinibsmall molecule

2 trials (2 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Fludarabinesmall molecule

2 trials (0 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Ivosidenibsmall molecule

2 trials (2 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Larotrectinibsmall molecule

2 trials (2 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Melphalansmall molecule

2 trials (0 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Olaparibsmall molecule

2 trials (1 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Palbociclibsmall molecule

2 trials (1 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Samotolisibsmall molecule

2 trials (1 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Selpercatinibsmall molecule

2 trials (2 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Tazemetostatsmall molecule

2 trials (1 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Tipifarnibsmall molecule

2 trials (2 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Vemurafenibsmall_molecule

2 trials (1 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Clofarabinesmall molecule

1 trials (0 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Cobimetinibsmall molecule

1 trials (1 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Dabrafenibsmall molecule

1 trials (1 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Filgrastimother

1 trials (0 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Lenalidomidesmall molecule

1 trials (1 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Rituximabmonoclonal antibody

1 trials (0 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Selumetinibsmall molecule

1 trials (1 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Sunitinibsmall molecule

1 trials (0 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Trametinibsmall molecule

1 trials (1 active) · roll-up of the cancer and its descendants

—

Observed

Langerhans Cell Histiocytosis studied in …STUDIED_INderived10 of 27show all (up to 200)
→ studied in	NCT03210714Phase 2 · active not recruiting Erdafitinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With FGFR Mutations (A Pediatric MATCH Treatment Trial) · condition mapped CURATED_BROADER · 27 trials mapped (14 active)	—	—	Langerhans Cell Histiocytosis	1	Observed	clinicaltrials	graph →
→ studied in	NCT03698994Phase 2 · active not recruiting Ulixertinib in Treating Patients With Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With MAPK Pathway Mutations (A Pediatric MATCH Treatment Trial) · condition mapped CURATED_BROADER · 27 trials mapped (14 active)	—	—	Langerhans Cell Histiocytosis	1	Observed	clinicaltrials	graph →
→ studied in	NCT02402244recruiting Project: Every Child for Younger Patients With Cancer · condition mapped ONTOLOGY_EXACT · 27 trials mapped (14 active)	—	—	Childhood Langerhans Cell Histiocytosis	1	Observed	clinicaltrials	graph →
→ studied in	NCT07440290Phase 2/Phase 3 · recruiting DETERMINE Trial Treatment Arm 07: Dabrafenib in Combination With Trametinib in Adult, Paediatric and Teenage/Young Adult Patients With BRAF V600 Mutation-Positive Cancers. · condition mapped ONTOLOGY_EXACT · 27 trials mapped (14 active)	—	—	Langerhans Cell Histiocytosis	1	Observed	clinicaltrials	graph →
→ studied in	NCT05028621NA · suspended Molecular Basis of Langerhans and Non-Langerhans Cell Histiocytic Neoplasms and Castleman Disease · condition mapped ONTOLOGY_EXACT · 27 trials mapped (14 active)	—	—	Langerhans Cell Histiocytosis	1	Observed	clinicaltrials	graph →
→ studied in	NCT04320888Phase 2 · active not recruiting Selpercatinib for the Treatment of Advanced Solid Tumors, Lymphomas, or Histiocytic Disorders With Activating RET Gene Alterations, a Pediatric MATCH Treatment Trial · condition mapped CURATED_BROADER · 27 trials mapped (14 active)	—	—	Langerhans Cell Histiocytosis	1	Observed	clinicaltrials	graph →
→ studied in	NCT03155620Phase 2 · active not recruiting Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial) · condition mapped ONTOLOGY_EXACT · 27 trials mapped (14 active)	—	—	Langerhans Cell Histiocytosis	1	Observed	clinicaltrials	graph →
→ studied in	NCT02523040Phase 2 · active not recruiting Lenalidomide for Adult Histiocyte Disorders · condition mapped ONTOLOGY_EXACT · 27 trials mapped (14 active)	—	—	Langerhans Cell Histiocytosis	1	Observed	clinicaltrials	graph →
→ studied in	NCT04284774Phase 2 · active not recruiting Tipifarnib for the Treatment of Advanced Solid Tumors, Lymphoma, or Histiocytic Disorders With HRAS Gene Alterations, a Pediatric MATCH Treatment Trial · condition mapped CURATED_BROADER · 27 trials mapped (14 active)	—	—	Langerhans Cell Histiocytosis	1	Observed	clinicaltrials	graph →
→ studied in	NCT03213652Phase 2 · active not recruiting Ensartinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With ALK or ROS1 Genomic Alterations (A Pediatric MATCH Treatment Trial) · condition mapped CURATED_BROADER · 27 trials mapped (14 active)	—	—	Langerhans Cell Histiocytosis	1	Observed	clinicaltrials	graph →

Langerhans Cell Histiocytosis studied in …STUDIED_INderived10 of 27show all (up to 200)

→ studied in

NCT03210714Phase 2 · active not recruiting

Erdafitinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With FGFR Mutations (A Pediatric MATCH Treatment Trial) · condition mapped CURATED_BROADER · 27 trials mapped (14 active)

—

Observed

→ studied in

NCT03698994Phase 2 · active not recruiting

Ulixertinib in Treating Patients With Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With MAPK Pathway Mutations (A Pediatric MATCH Treatment Trial) · condition mapped CURATED_BROADER · 27 trials mapped (14 active)

—

Observed

Childhood Langerhans Cell Histiocytosis

→ studied in

NCT02402244recruiting

Project: Every Child for Younger Patients With Cancer · condition mapped ONTOLOGY_EXACT · 27 trials mapped (14 active)

—

Observed

→ studied in

NCT07440290Phase 2/Phase 3 · recruiting

DETERMINE Trial Treatment Arm 07: Dabrafenib in Combination With Trametinib in Adult, Paediatric and Teenage/Young Adult Patients With BRAF V600 Mutation-Positive Cancers. · condition mapped ONTOLOGY_EXACT · 27 trials mapped (14 active)

—

Observed

→ studied in

NCT05028621NA · suspended

Molecular Basis of Langerhans and Non-Langerhans Cell Histiocytic Neoplasms and Castleman Disease · condition mapped ONTOLOGY_EXACT · 27 trials mapped (14 active)

—

Observed

→ studied in

NCT04320888Phase 2 · active not recruiting

Selpercatinib for the Treatment of Advanced Solid Tumors, Lymphomas, or Histiocytic Disorders With Activating RET Gene Alterations, a Pediatric MATCH Treatment Trial · condition mapped CURATED_BROADER · 27 trials mapped (14 active)

—

Observed

→ studied in

NCT03155620Phase 2 · active not recruiting

Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial) · condition mapped ONTOLOGY_EXACT · 27 trials mapped (14 active)

—

Observed

→ studied in

NCT02523040Phase 2 · active not recruiting

Lenalidomide for Adult Histiocyte Disorders · condition mapped ONTOLOGY_EXACT · 27 trials mapped (14 active)

—

Observed

→ studied in

NCT04284774Phase 2 · active not recruiting

Tipifarnib for the Treatment of Advanced Solid Tumors, Lymphoma, or Histiocytic Disorders With HRAS Gene Alterations, a Pediatric MATCH Treatment Trial · condition mapped CURATED_BROADER · 27 trials mapped (14 active)

—

Observed

→ studied in

NCT03213652Phase 2 · active not recruiting

Ensartinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With ALK or ROS1 Genomic Alterations (A Pediatric MATCH Treatment Trial) · condition mapped CURATED_BROADER · 27 trials mapped (14 active)

—

Observed