Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor

cancer family

Identifier: CI-CAN-00000175
Entity page: /cancer/ewing-sarcoma-peripheral-primitive-neuroectodermal-tumor ↗
Edges: 331

Neighbours: 2 genes16 drugs10 trials
Drawn: 28 of 28 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor approved for …APPROVED_FORderived1 of 1
← approved for	Dactinomycinother FDA (US) · approved · 2017-11-09 · adult and pediatric patients with Ewing sarcoma, as part of a multi-phase, combination chemotherapy regimen.	—	approved	Ewing Sarcoma	1	Regulatory	openfda	graph →
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor altered in cohorts of …

Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 75show all (up to 200)
→ investigated in trials for	Temozolomidesmall molecule 21 trials (9 active) · roll-up of the cancer and its descendants	—	—	Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor	21	Observed	clinicaltrials	graph →
→ investigated in trials for	Cyclophosphamidesmall molecule 20 trials (8 active) · roll-up of the cancer and its descendants	—	—	Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor	20	Observed	clinicaltrials	graph →
→ investigated in trials for	Irinotecansmall molecule 20 trials (8 active) · roll-up of the cancer and its descendants	—	—	Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor	20	Observed	clinicaltrials	graph →
→ investigated in trials for	Vincristinesmall molecule 16 trials (7 active) · roll-up of the cancer and its descendants	—	—	Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor	16	Observed	clinicaltrials	graph →
→ investigated in trials for	Etoposidesmall molecule 12 trials (5 active) · roll-up of the cancer and its descendants	—	—	Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor	12	Observed	clinicaltrials	graph →
→ investigated in trials for	Topotecansmall molecule 12 trials (3 active) · roll-up of the cancer and its descendants	—	—	Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor	12	Observed	clinicaltrials	graph →
→ investigated in trials for	Ifosfamidesmall molecule 10 trials (5 active) · roll-up of the cancer and its descendants	—	—	Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor	10	Observed	clinicaltrials	graph →
→ investigated in trials for	Doxorubicinsmall molecule 9 trials (4 active) · roll-up of the cancer and its descendants	—	—	Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor	9	Observed	clinicaltrials	graph →
→ investigated in trials for	Melphalansmall molecule 8 trials (0 active) · roll-up of the cancer and its descendants	—	—	Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor	8	Observed	clinicaltrials	graph →
→ investigated in trials for	Busulfansmall molecule 7 trials (0 active) · roll-up of the cancer and its descendants	—	—	Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor	7	Observed	clinicaltrials	graph →
→ investigated in trials for	Fludarabinesmall molecule 6 trials (2 active) · roll-up of the cancer and its descendants	—	—	Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor	6	Observed	clinicaltrials	graph →
→ investigated in trials for	Cabozantinibsmall molecule 5 trials (4 active) · roll-up of the cancer and its descendants	—	—	Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Bevacizumabmonoclonal antibody 4 trials (1 active) · roll-up of the cancer and its descendants	—	—	Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Filgrastimother 4 trials (1 active) · roll-up of the cancer and its descendants	—	—	Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Ganitumabmonoclonal antibody 4 trials (1 active) · roll-up of the cancer and its descendants	—	—	Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor	4	Observed	clinicaltrials	graph →

Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 75show all (up to 200)

→ investigated in trials for

Temozolomidesmall molecule

21 trials (9 active) · roll-up of the cancer and its descendants

—

Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Observed

Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor studied in …STUDIED_INderived10 of 253show all (up to 200)
→ studied in	NCT06441331Phase 1 · recruiting Phase I Trial to Determine the Dose and Evaluate the PK and Safety of Lutetium Lu 177 Edotreotide Therapy in Pediatric Participants With SSTR-positive Tumors · condition mapped ONTOLOGY_EXACT · 253 trials mapped (92 active)	—	—	Peripheral Primitive Neuroectodermal Tumor	1	Observed	clinicaltrials	graph →
→ studied in	NCT07194044Phase 1 · recruiting Metastatic Ewing's Trial Testing Schedule Enhancement to Improve Outcomes · condition mapped CURATED_BROADER · 253 trials mapped (92 active)	—	—	Ewing Sarcoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07297979Phase 1 · recruiting Evaluation of Xaluritamig in Adults, Adolescents and Children With Relapsed or Refractory Ewing Sarcoma (EWS) · condition mapped ONTOLOGY_EXACT · 253 trials mapped (92 active)	—	—	Ewing Sarcoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06926283Phase 1 · recruiting A Study of DXC008 in Patients With Prostate Cancer and Other Solid Tumors · condition mapped ONTOLOGY_EXACT · 253 trials mapped (92 active)	—	—	Ewing Sarcoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT03210714Phase 2 · active not recruiting Erdafitinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With FGFR Mutations (A Pediatric MATCH Treatment Trial) · condition mapped CURATED_BROADER · 253 trials mapped (92 active)	—	—	Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor	1	Observed	clinicaltrials	graph →
→ studied in	NCT07830667Phase 1/Phase 2 · not yet recruiting A Phase 1/2 Study of CBX-12 in Children, Adolescents, or Young Adults With Solid Tumors That Have Come Back After Treatment or Are Difficult to Treat · condition mapped CURATED_BROADER · 253 trials mapped (92 active)	—	—	Childhood Ewing Sarcoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT03698994Phase 2 · active not recruiting Ulixertinib in Treating Patients With Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With MAPK Pathway Mutations (A Pediatric MATCH Treatment Trial) · condition mapped CURATED_BROADER · 253 trials mapped (92 active)	—	—	Ewing Sarcoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06395103Phase 1/Phase 2 · recruiting Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01) · condition mapped ONTOLOGY_EXACT · 253 trials mapped (92 active)	—	—	Ewing Sarcoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07695311Phase 1 · not yet recruiting EWSR1 Immunotherapy in Ewing Sarcoma and DSRCT · condition mapped ONTOLOGY_EXACT · 253 trials mapped (92 active)	—	—	Ewing Sarcoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT03715933Phase 1 · recruiting Phase 1 Study of INBRX-109 in Subjects With Locally Advanced or Metastatic Solid Tumors Including Sarcomas · condition mapped ONTOLOGY_EXACT · 253 trials mapped (92 active)	—	—	Ewing Sarcoma	1	Observed	clinicaltrials	graph →

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