Adult B Acute Lymphoblastic Leukemia

hematologic malignancy

Identifier: CI-CAN-00004348
Entity page: /cancer/adult-b-acute-lymphoblastic-leukemia ↗
Edges: 108

Neighbours: 2 genes2 variants16 drugs10 trials
Drawn: 30 of 30 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Adult B Acute Lymphoblastic Leukemia predicts response to …PREDICTS_RESPONSE_TO1 of 1
in context · predicts response to	FLT3 Overexpressionexpression → predicts response to Sunitinib	sensitivity	C	Adult B Acute Lymphoblastic Leukemia	1	Curated	civic	graph →
Adult B Acute Lymphoblastic Leukemia …

Adult B Acute Lymphoblastic Leukemia associated with …ASSOCIATED_WITH2 of 2
← associated with	CRLF2	supports	B	Adult B Acute Lymphoblastic Leukemia	1	Curated	civic	graph →
← associated with	FLT3	supports	C	Adult B Acute Lymphoblastic Leukemia	1	Curated	civic	graph →

Adult B Acute Lymphoblastic Leukemia associated with …ASSOCIATED_WITH2 of 2

← associated with

CRLF2

supports

Adult B Acute Lymphoblastic Leukemia investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 44show all (up to 200)
→ investigated in trials for	Cyclophosphamidesmall molecule 17 trials (3 active) · roll-up of the cancer and its descendants	—	—	Adult B Acute Lymphoblastic Leukemia	17	Observed	clinicaltrials	graph →
→ investigated in trials for	Cytarabinesmall molecule 12 trials (1 active) · roll-up of the cancer and its descendants	—	—	Adult B Acute Lymphoblastic Leukemia	12	Observed	clinicaltrials	graph →
→ investigated in trials for	Vincristinesmall molecule 12 trials (1 active) · roll-up of the cancer and its descendants	—	—	Adult B Acute Lymphoblastic Leukemia	12	Observed	clinicaltrials	graph →
→ investigated in trials for	Methotrexatesmall molecule 11 trials (1 active) · roll-up of the cancer and its descendants	—	—	Adult B Acute Lymphoblastic Leukemia	11	Observed	clinicaltrials	graph →
→ investigated in trials for	Dexamethasonesmall molecule 9 trials (1 active) · roll-up of the cancer and its descendants	—	—	Adult B Acute Lymphoblastic Leukemia	9	Observed	clinicaltrials	graph →
→ investigated in trials for	Doxorubicinsmall molecule 8 trials (1 active) · roll-up of the cancer and its descendants	—	—	Adult B Acute Lymphoblastic Leukemia	8	Observed	clinicaltrials	graph →
→ investigated in trials for	Prednisonesmall molecule 8 trials (1 active) · roll-up of the cancer and its descendants	—	—	Adult B Acute Lymphoblastic Leukemia	8	Observed	clinicaltrials	graph →
→ investigated in trials for	Fludarabinesmall molecule 7 trials (2 active) · roll-up of the cancer and its descendants	—	—	Adult B Acute Lymphoblastic Leukemia	7	Observed	clinicaltrials	graph →
→ investigated in trials for	Leucovorinsmall molecule 7 trials (1 active) · roll-up of the cancer and its descendants	—	—	Adult B Acute Lymphoblastic Leukemia	7	Observed	clinicaltrials	graph →
→ investigated in trials for	Mercaptopurinesmall molecule 7 trials (0 active) · roll-up of the cancer and its descendants	—	—	Adult B Acute Lymphoblastic Leukemia	7	Observed	clinicaltrials	graph →
→ investigated in trials for	Daunorubicinsmall molecule 6 trials (0 active) · roll-up of the cancer and its descendants	—	—	Adult B Acute Lymphoblastic Leukemia	6	Observed	clinicaltrials	graph →
→ investigated in trials for	Pegaspargaseother 6 trials (0 active) · roll-up of the cancer and its descendants	—	—	Adult B Acute Lymphoblastic Leukemia	6	Observed	clinicaltrials	graph →
→ investigated in trials for	Rituximabmonoclonal antibody 6 trials (0 active) · roll-up of the cancer and its descendants	—	—	Adult B Acute Lymphoblastic Leukemia	6	Observed	clinicaltrials	graph →
→ investigated in trials for	Blinatumomabmonoclonal antibody 5 trials (2 active) · roll-up of the cancer and its descendants	—	—	Adult B Acute Lymphoblastic Leukemia	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Dasatinibsmall molecule 5 trials (1 active) · roll-up of the cancer and its descendants	—	—	Adult B Acute Lymphoblastic Leukemia	5	Observed	clinicaltrials	graph →

Adult B Acute Lymphoblastic Leukemia studied in …STUDIED_INderived10 of 59show all (up to 200)
→ studied in	NCT00792948Phase 2 · active not recruiting Combination Chemotherapy With or Without Donor Stem Cell Transplant in Treating Patients With Acute Lymphoblastic Leukemia · condition mapped ONTOLOGY_EXACT · 59 trials mapped (12 active)	—	—	Adult B Acute Lymphoblastic Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT07313852Phase 1/Phase 2 · not yet recruiting A Study of Inotuzumab and Blinatumomab in People With B-cell Acute Lymphoblastic Leukemia · condition mapped ALIAS · 59 trials mapped (12 active)	—	—	Adult B Acute Lymphoblastic Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT02997761Phase 2 · completed Ibrutinib and Blinatumomab in Treating Patients With Relapsed or Refractory B Acute Lymphoblastic Leukemia · condition mapped ONTOLOGY_EXACT · 59 trials mapped (12 active)	—	—	Adult B Acute Lymphoblastic Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT03984968Phase 1/Phase 2 · active not recruiting CD19 CAR-T Consolidation Therapy for Acute Lymphoblastic Leukemia · condition mapped ALIAS · 59 trials mapped (12 active)	—	—	Adult B Acute Lymphoblastic Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT07412405NA · not yet recruiting This Clinical Trial is a Single-arm, Non-randomized Pilot Trial to Determine the Safety of Administering Autologous Anti-C19 Cells (ARI-0001) and the Feasibility of Local CAR-T Cell Production in Patients Over 18 Years of Age With Relapsed/Refractory (R/R) CD19+ Hematologic Malignancies, Including R · condition mapped ALIAS · 59 trials mapped (12 active)	—	—	Adult B Acute Lymphoblastic Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT07277504early Phase 1 · not yet recruiting Autologous Bedside CD19 CAR T-cell Therapy for B-ALL · condition mapped ALIAS · 59 trials mapped (12 active)	—	—	Adult B Acute Lymphoblastic Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT07256353early Phase 1 · not yet recruiting Allogeneic UCB-derived CAR-T for B-ALL · condition mapped ALIAS · 59 trials mapped (12 active)	—	—	Adult B Acute Lymphoblastic Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT01139970Phase 1 · completed Veliparib and Temozolomide in Treating Patients With Acute Leukemia · condition mapped ONTOLOGY_EXACT · 59 trials mapped (12 active)	—	—	Adult B Acute Lymphoblastic Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT03160079Phase 1/Phase 2 · completed Blinatumomab & Pembrolizumab for Adults With Relapsed/Refractory B-cell ALL With High Marrow Lymphoblasts · condition mapped ALIAS · 59 trials mapped (12 active)	—	—	Adult B Acute Lymphoblastic Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT04035434Phase 1/Phase 2 · terminated A Safety and Efficacy Study Evaluating CTX110 in Subjects With Relapsed or Refractory B-Cell Malignancies (CARBON) · condition mapped ALIAS · 59 trials mapped (12 active)	—	—	Adult B Acute Lymphoblastic Leukemia	1	Observed	clinicaltrials	graph →

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