Acute Myeloid Leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1

molecular subtype

Identifier: CI-CAN-00009226
Entity page: /cancer/acute-myeloid-leukemia-with-t-8-21-q22-q22-1-runx1-runx1t1 ↗
Edges: 224

Neighbours: 1 genes1 variants15 drugs10 trials
Drawn: 27 of 27 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Acute Myeloid Leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1 prognostic in …PROGNOSTIC_IN1 of 1
← prognostic in	RUNX1T1 Fusionfusion	supports	A	Acute Myeloid Leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1	1	Curated	civic	graph →
Acute Myeloid Leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1 diagnostic of …DIAGNOSTIC_OF

Acute Myeloid Leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1 associated with …ASSOCIATED_WITH2 of 2
← associated with	RUNX1T1 2 source records aggregated	supports	A	Acute Myeloid Leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1	2	Curated	civic	graph →
← associated with	RUNX1T1 3 source records aggregated	supports	B	Acute Myeloid Leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1	3	Curated	civic	graph →

Acute Myeloid Leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1 associated with …ASSOCIATED_WITH2 of 2

← associated with

RUNX1T1

2 source records aggregated

supports

Acute Myeloid Leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1

Curated

Acute Myeloid Leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1 investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 53show all (up to 200)
→ investigated in trials for	Cytarabinesmall molecule 45 trials (1 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1	45	Observed	clinicaltrials	graph →
→ investigated in trials for	Fludarabinesmall molecule 25 trials (1 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1	25	Observed	clinicaltrials	graph →
→ investigated in trials for	Etoposidesmall molecule 16 trials (1 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1	16	Observed	clinicaltrials	graph →
→ investigated in trials for	Decitabinesmall molecule 14 trials (1 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1	14	Observed	clinicaltrials	graph →
→ investigated in trials for	Mitoxantronesmall molecule 14 trials (0 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1	14	Observed	clinicaltrials	graph →
→ investigated in trials for	Cyclophosphamidesmall molecule 13 trials (1 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1	13	Observed	clinicaltrials	graph →
→ investigated in trials for	Busulfansmall molecule 12 trials (0 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1	12	Observed	clinicaltrials	graph →
→ investigated in trials for	Idarubicinsmall molecule 11 trials (1 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1	11	Observed	clinicaltrials	graph →
→ investigated in trials for	Methotrexatesmall molecule 11 trials (0 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1	11	Observed	clinicaltrials	graph →
→ investigated in trials for	Daunorubicinsmall molecule 10 trials (0 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1	10	Observed	clinicaltrials	graph →
→ investigated in trials for	Tipifarnibsmall molecule 10 trials (0 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1	10	Observed	clinicaltrials	graph →
→ investigated in trials for	Azacitidinesmall molecule 9 trials (1 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1	9	Observed	clinicaltrials	graph →
→ investigated in trials for	Filgrastimother 9 trials (1 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1	9	Observed	clinicaltrials	graph →
→ investigated in trials for	Vorinostatsmall molecule 8 trials (0 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1	8	Observed	clinicaltrials	graph →
→ investigated in trials for	Alvocidibsmall molecule 6 trials (0 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1	6	Observed	clinicaltrials	graph →

Acute Myeloid Leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1 studied in …STUDIED_INderived10 of 166show all (up to 200)
→ studied in	NCT00801489Phase 2 · recruiting Fludarabine Phosphate, Cytarabine, Filgrastim-sndz, Gemtuzumab Ozogamicin, and Idarubicin Hydrochloride in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome · condition mapped ONTOLOGY_EXACT · 166 trials mapped (5 active)	—	—	Acute Myeloid Leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1	1	Observed	clinicaltrials	graph →
→ studied in	NCT02071901Phase 2 · completed Eltrombopag Olamine in Improving Platelet Recovery in Older Patients With Acute Myeloid Leukemia Undergoing Chemotherapy · condition mapped ALIAS · 166 trials mapped (5 active)	—	—	Acute Myeloid Leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1	1	Observed	clinicaltrials	graph →
→ studied in	NCT00093470Phase 3 · completed Tipifarnib in Treating Patients With Acute Myeloid Leukemia in Remission · condition mapped ONTOLOGY_EXACT · 166 trials mapped (5 active)	—	—	Adult Acute Myeloid Leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1	1	Observed	clinicaltrials	graph →
→ studied in	NCT00658814Phase 2 · active not recruiting Azacitidine and Gemtuzumab Ozogamicin in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia · condition mapped ONTOLOGY_EXACT · 166 trials mapped (5 active)	—	—	Adult Acute Myeloid Leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1	1	Observed	clinicaltrials	graph →
→ studied in	NCT02094794Phase 2 · active not recruiting Total Marrow and Lymphoid Irradiation and Chemotherapy Before DSCT in Treating Patients With High-Risk ALL or AML · condition mapped ALIAS · 166 trials mapped (5 active)	—	—	Acute Myeloid Leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1	1	Observed	clinicaltrials	graph →
→ studied in	NCT00085124Phase 3 · completed Daunorubicin Hydrochloride, Cytarabine and Oblimersen Sodium in Treating Patients With Previously Untreated Acute Myeloid Leukemia · condition mapped ALIAS · 166 trials mapped (5 active)	—	—	Acute Myeloid Leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1	1	Observed	clinicaltrials	graph →
→ studied in	NCT01384513Phase 2 · completed A Two-Step Approach to Reduced Intensity Bone Marrow Transplant for Patients With Hematological Malignancies · condition mapped ALIAS · 166 trials mapped (5 active)	—	—	Acute Myeloid Leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1	1	Observed	clinicaltrials	graph →
→ studied in	NCT01199562active not recruiting Infection Prophylaxis and Management in Treating Cytomegalovirus (CMV) Infection in Patients With Hematologic Malignancies Previously Treated With Donor Stem Cell Transplant · condition mapped ALIAS · 166 trials mapped (5 active)	—	—	Acute Myeloid Leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1	1	Observed	clinicaltrials	graph →
→ studied in	NCT01869114Phase 2 · completed Sirolimus and Azacitidine in Treating Patients With High Risk Myelodysplastic Syndrome or Acute Myeloid Leukemia That is Recurrent or Not Eligible for Intensive Chemotherapy · condition mapped ALIAS · 166 trials mapped (5 active)	—	—	Acute Myeloid Leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1	1	Observed	clinicaltrials	graph →
→ studied in	NCT01139970Phase 1 · completed Veliparib and Temozolomide in Treating Patients With Acute Leukemia · condition mapped ONTOLOGY_EXACT · 166 trials mapped (5 active)	—	—	Adult Acute Myeloid Leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1	1	Observed	clinicaltrials	graph →

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