Acute Myeloid Leukemia with KMT2A Rearrangement

molecular subtype

Identifier: CI-CAN-00008665
Entity page: /cancer/acute-myeloid-leukemia-with-kmt2a-rearrangement ↗
Edges: 49

Neighbours: 1 genes1 variants15 drugs10 trials
Drawn: 27 of 27 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Acute Myeloid Leukemia with KMT2A Rearrangement diagnostic of …DIAGNOSTIC_OF2 of 2
← diagnostic of	KMT2A Fusionfusion	supports	A	Acute Myeloid Leukemia with KMT2A Rearrangement	1	Curated	civic	graph →
← diagnostic of	KMT2A Fusionfusion 3 source records aggregated	supports

Acute Myeloid Leukemia with KMT2A Rearrangement associated with …ASSOCIATED_WITH2 of 2
← associated with	KMT2A	supports	A	Acute Myeloid Leukemia with KMT2A Rearrangement	1	Curated	civic	graph →
← associated with	KMT2A 3 source records aggregated	supports	B	Acute Myeloid Leukemia with KMT2A Rearrangement	3	Curated	civic	graph →

Acute Myeloid Leukemia with KMT2A Rearrangement associated with …ASSOCIATED_WITH2 of 2

← associated with

KMT2A

supports

Acute Myeloid Leukemia with KMT2A Rearrangement

Curated

Acute Myeloid Leukemia with KMT2A Rearrangement investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 27show all (up to 200)
→ investigated in trials for	Azacitidinesmall molecule 6 trials (1 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with KMT2A Rearrangement	6	Observed	clinicaltrials	graph →
→ investigated in trials for	Cytarabinesmall molecule 4 trials (2 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with KMT2A Rearrangement	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Fludarabinesmall molecule 3 trials (1 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with KMT2A Rearrangement	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Busulfansmall molecule 2 trials (1 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with KMT2A Rearrangement	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Daunorubicinsmall molecule 2 trials (2 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with KMT2A Rearrangement	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Revumenibsmall molecule 2 trials (2 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with KMT2A Rearrangement	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Tipifarnibsmall molecule 2 trials (0 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with KMT2A Rearrangement	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Veliparibsmall molecule 2 trials (0 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with KMT2A Rearrangement	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Belinostatsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with KMT2A Rearrangement	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Bortezomibsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with KMT2A Rearrangement	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Carboplatinsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with KMT2A Rearrangement	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Clofarabinesmall molecule 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with KMT2A Rearrangement	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Cyclophosphamidesmall molecule 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with KMT2A Rearrangement	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Decitabinesmall molecule 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with KMT2A Rearrangement	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Etoposidesmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with KMT2A Rearrangement	1	Observed	clinicaltrials	graph →

Acute Myeloid Leukemia with KMT2A Rearrangement studied in …STUDIED_INderived10 of 18show all (up to 200)
→ studied in	NCT05886049Phase 1 · recruiting A Phase 1b Study of Menin Inhibitor SNDX- 5613 in Combination With Daunorubicin and Cytarabine in Newly Diagnosed Patients With Acute Myeloid Leukemia and NPM1 Mutated/FLT3 Wildtype or MLL/KMT2A Rearranged or NUP98 Alterations Disease · condition mapped ONTOLOGY_EXACT · 18 trials mapped (5 active)	—	—	Acute Myeloid Leukemia with KMT2A Rearrangement	1	Observed	clinicaltrials	graph →
→ studied in	NCT02727803Phase 2 · recruiting Personalized NK Cell Therapy in CBT · condition mapped ALIAS · 18 trials mapped (5 active)	—	—	Acute Myeloid Leukemia with a Variant KMT2A Rearrangement	1	Observed	clinicaltrials	graph →
→ studied in	NCT00658814Phase 2 · active not recruiting Azacitidine and Gemtuzumab Ozogamicin in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia · condition mapped ONTOLOGY_EXACT · 18 trials mapped (5 active)	—	—	Adult Acute Myeloid Leukemia with t(9;11)(p21.3;q23.3); MLLT3-KMT2A	1	Observed	clinicaltrials	graph →
→ studied in	NCT06222580Phase 1 · recruiting SNDX-5613 and Gilteritinib for the Treatment of Relapsed or Refractory FLT3-Mutated Acute Myeloid Leukemia and Concurrent MLL-Rearrangement or NPM1 Mutation · condition mapped ONTOLOGY_EXACT · 18 trials mapped (5 active)	—	—	Acute Myeloid Leukemia with KMT2A Rearrangement	1	Observed	clinicaltrials	graph →
→ studied in	NCT01627041Phase 2 · active not recruiting Decitabine, Cytarabine, and Daunorubicin Hydrochloride in Treating Patients With Acute Myeloid Leukemia · condition mapped ONTOLOGY_EXACT · 18 trials mapped (5 active)	—	—	Adult Acute Myeloid Leukemia with t(9;11)(p21.3;q23.3); MLLT3-KMT2A	1	Observed	clinicaltrials	graph →
→ studied in	NCT01139970Phase 1 · completed Veliparib and Temozolomide in Treating Patients With Acute Leukemia · condition mapped ONTOLOGY_EXACT · 18 trials mapped (5 active)	—	—	Adult Acute Myeloid Leukemia with t(9;11)(p21.3;q23.3); MLLT3-KMT2A	1	Observed	clinicaltrials	graph →
→ studied in	NCT00588991Phase 1 · completed Veliparib and Topotecan With or Without Carboplatin in Treating Patients With Relapsed or Refractory Acute Leukemia, High-Risk Myelodysplasia, or Aggressive Myeloproliferative Disorders · condition mapped ONTOLOGY_EXACT · 18 trials mapped (5 active)	—	—	Adult Acute Myeloid Leukemia with t(9;11)(p21.3;q23.3); MLLT3-KMT2A	1	Observed	clinicaltrials	graph →
→ studied in	NCT03701295Phase 1/Phase 2 · completed Pinometostat and Azacitidine in Treating Patients With Relapsed, Refractory, or Newly Diagnosed Acute Myeloid Leukemia With 11q23 Rearrangement · condition mapped ALIAS · 18 trials mapped (5 active)	—	—	Acute Myeloid Leukemia with t(9;11)(p21.3;q23.3); MLLT3-KMT2A	1	Observed	clinicaltrials	graph →
→ studied in	NCT01168219Phase 2 · completed Busulfan, Fludarabine Phosphate, and Anti-Thymocyte Globulin Followed By Donor Stem Cell Transplant and Azacitidine in Treating Patients With High-Risk Myelodysplastic Syndrome and Older Patients With Acute Myeloid Leukemia · condition mapped ALIAS · 18 trials mapped (5 active)	—	—	Acute Myeloid Leukemia with t(9;11)(p21.3;q23.3); MLLT3-KMT2A	1	Observed	clinicaltrials	graph →
→ studied in	NCT00105001Phase 2 · completed Tacrolimus and Mycophenolate Mofetil With or Without Sirolimus in Preventing Acute Graft-Versus-Host Disease in Patients Who Are Undergoing Donor Stem Cell Transplant for Hematologic Cancer · condition mapped ALIAS · 18 trials mapped (5 active)	—	—	Adult Acute Myeloid Leukemia with t(9;11)(p21.3;q23.3); MLLT3-KMT2A	1	Observed	clinicaltrials	graph →

Radial view

Every edge, grouped by relationship

Strongest chains