Acute Myeloid Leukemia with Genetic Abnormalities

hematologic malignancy

Identifier: CI-CAN-00004303
Entity page: /cancer/acute-myeloid-leukemia-with-genetic-abnormalities ↗
Edges: 340

Neighbours: 16 drugs10 trials
Drawn: 26 of 26 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Acute Myeloid Leukemia with Genetic Abnormalities approved for …APPROVED_FORderived6 of 6
← approved for	Arsenic Trioxidesmall molecule EMA (EU) · approved · 2020-09-17 · Arsenic trioxide medac is indicated for induction of remission, and consolidation in adult patients with: Newly diagnosed low-to-intermedia…	—	approved	Acute Promyelocytic Leukemia	1	Regulatory	ema	graph →
← approved for

Acute Myeloid Leukemia with Genetic Abnormalities investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 70show all (up to 200)
→ investigated in trials for	Cytarabinesmall molecule 61 trials (9 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with Genetic Abnormalities	61	Observed	clinicaltrials	graph →
→ investigated in trials for	Fludarabinesmall molecule 30 trials (3 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with Genetic Abnormalities	30	Observed	clinicaltrials	graph →
→ investigated in trials for	Arsenic Trioxidesmall molecule 20 trials (6 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with Genetic Abnormalities	20	Observed	clinicaltrials	graph →
→ investigated in trials for	Cyclophosphamidesmall molecule 20 trials (3 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with Genetic Abnormalities	20	Observed	clinicaltrials	graph →
→ investigated in trials for	Idarubicinsmall molecule 20 trials (4 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with Genetic Abnormalities	20	Observed	clinicaltrials	graph →
→ investigated in trials for	Etoposidesmall molecule 19 trials (1 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with Genetic Abnormalities	19	Observed	clinicaltrials	graph →
→ investigated in trials for	Mitoxantronesmall molecule 19 trials (1 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with Genetic Abnormalities	19	Observed	clinicaltrials	graph →
→ investigated in trials for	Decitabinesmall molecule 18 trials (3 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with Genetic Abnormalities	18	Observed	clinicaltrials	graph →
→ investigated in trials for	Tretinoinsmall molecule 18 trials (6 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with Genetic Abnormalities	18	Observed	clinicaltrials	graph →
→ investigated in trials for	Daunorubicinsmall molecule 17 trials (4 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with Genetic Abnormalities	17	Observed	clinicaltrials	graph →
→ investigated in trials for	Busulfansmall molecule 16 trials (1 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with Genetic Abnormalities	16	Observed	clinicaltrials	graph →
→ investigated in trials for	Methotrexatesmall molecule 16 trials (1 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with Genetic Abnormalities	16	Observed	clinicaltrials	graph →
→ investigated in trials for	Azacitidinesmall molecule 12 trials (3 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with Genetic Abnormalities	12	Observed	clinicaltrials	graph →
→ investigated in trials for	Bortezomibsmall molecule 11 trials (0 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with Genetic Abnormalities	11	Observed	clinicaltrials	graph →
→ investigated in trials for	Filgrastimother 11 trials (2 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with Genetic Abnormalities	11	Observed	clinicaltrials	graph →

Acute Myeloid Leukemia with Genetic Abnormalities investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 70show all (up to 200)

→ investigated in trials for

Cytarabinesmall molecule

61 trials (9 active) · roll-up of the cancer and its descendants

—

Acute Myeloid Leukemia with Genetic Abnormalities

Observed

Acute Myeloid Leukemia with Genetic Abnormalities studied in …STUDIED_INderived10 of 264show all (up to 200)
→ studied in	NCT07504458Phase 3 · recruiting Pivotal Open-label Phase 3 Clinical Study of QTX-2101 in Adult Patients With Acute Promyelocytic Leukemia · condition mapped ONTOLOGY_EXACT · 264 trials mapped (33 active)	—	—	Acute Promyelocytic Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT06917911Phase 2 · recruiting Testing the Addition of Venetoclax or Gemtuzumab Ozogamicin (GO) to Usual Treatment Regimen (Cytarabine and Daunorubicin, "7+3") for Core Binding Factor Acute Myeloid Leukemia (CBF-AML) to Improve Response (A MYELOMATCH Treatment Trial) · condition mapped ONTOLOGY_EXACT · 264 trials mapped (33 active)	—	—	Core Binding Factor Acute Myeloid Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT00801489Phase 2 · recruiting Fludarabine Phosphate, Cytarabine, Filgrastim-sndz, Gemtuzumab Ozogamicin, and Idarubicin Hydrochloride in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome · condition mapped ONTOLOGY_EXACT · 264 trials mapped (33 active)	—	—	Acute Myeloid Leukemia with inv(16)(p13.1q22); CBFB-MYH11	1	Observed	clinicaltrials	graph →
→ studied in	NCT02938858completed French Registry of First-line Treatment of Acute Promyelocytic Leukemia · condition mapped ONTOLOGY_EXACT · 264 trials mapped (33 active)	—	—	Acute Promyelocytic Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT07566585Phase 1 · withdrawn Dose Finding Study to Evaluate the Safety of BSB-2002 in Relapsed or Refractory Acute Myeloid Leukemia (AML) Patients With NPM1 Mutation · condition mapped ALIAS · 264 trials mapped (33 active)	—	—	Acute Myeloid Leukemia with NPM1 Mutation	1	Observed	clinicaltrials	graph →
→ studied in	NCT05886049Phase 1 · recruiting A Phase 1b Study of Menin Inhibitor SNDX- 5613 in Combination With Daunorubicin and Cytarabine in Newly Diagnosed Patients With Acute Myeloid Leukemia and NPM1 Mutated/FLT3 Wildtype or MLL/KMT2A Rearranged or NUP98 Alterations Disease · condition mapped ONTOLOGY_EXACT · 264 trials mapped (33 active)	—	—	Acute Myeloid Leukemia with KMT2A Rearrangement	1	Observed	clinicaltrials	graph →
→ studied in	NCT06001788Phase 1 · recruiting Safety and Tolerability of Ziftomenib Combinations in Patients With Relapsed/Refractory Acute Myeloid Leukemia · condition mapped ALIAS · 264 trials mapped (33 active)	—	—	Acute Myeloid Leukemia with NPM1 Mutation	1	Observed	clinicaltrials	graph →
→ studied in	NCT03147612Phase 2 · active not recruiting Low-Intensity Chemotherapy, Ponatinib and Blinatumomab in Treating Patients With Philadelphia Chromosome-Positive and/or BCR-ABL Positive Acute Lymphoblastic Leukemia · condition mapped ONTOLOGY_EXACT · 264 trials mapped (33 active)	—	—	Acute Myeloid Leukemia with BCR-ABL1	1	Observed	clinicaltrials	graph →
→ studied in	NCT02071901Phase 2 · completed Eltrombopag Olamine in Improving Platelet Recovery in Older Patients With Acute Myeloid Leukemia Undergoing Chemotherapy · condition mapped ALIAS · 264 trials mapped (33 active)	—	—	Adult Acute Myeloid Leukemia with t(16;16)(p13.1;q22); CBFB-MYH11	1	Observed	clinicaltrials	graph →
→ studied in	NCT03253848NA · active not recruiting Simplified Patient Care Strategy in Decreasing Early Death in Patients With Acute Promyelocytic Leukemia · condition mapped CURATED_BROADER · 264 trials mapped (33 active)	—	—	Acute Promyelocytic Leukemia with t(15;17)(q24.1;q21.2); PML-RARA	1	Observed	clinicaltrials	graph →

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