TUBB3 EXPRESSION

CI-VAR-00000924Explore in graph →CIViC 389

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Breast Neoplasm1
TUBB3 EXPRESSION	Taxane Compound	Predictive	B	Supports Sensitivity Response	2	accepted	EID921 High expression of betaIII-tubulin, as assessed in 85 breast cancers by IHC, was associated with better pathological response. PMID 23218766 · Wang et al., 2013 · Open in CIViC	civic
Malignant Neoplasm1
TUBB3 EXPRESSION	Paclitaxel	Predictive	D	Supports Resistance	2	accepted	EID920 High expression of class 3 beta-tubulin led to decreased effect of paclitaxel on cell motility in HeLa, MCF-7 and CHO cell lines. PMID 21576762 · Ganguly et al., 2011 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.