TMPRSS2

transmembrane serine protease 2

Explore in graph →CI-GENE-00035684HGNC:11876 ENSG00000184012 NCBI 7113 Approved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
TMPRSS2 TMPRSS2::ERG1
(diagnostic)	Malignant Prostate Neoplasm	Diagnostic	B	Supports Positive	4	rejected	EID1755 Non-invasive detection of multiple TMPRSS2:ERG fusion mutations in urine samples of patients with prostate cancer. Rapid 60 minute screening using DNA ligase and isothermal amplification to detect m… (full text at CIViC) PMID 27865106 · Koo et al., 2017 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (26)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved26 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Pediatric Pan-cancer (Columbia U, Genome Med 2016) mixed_pipseq_2017	unmapped	Ssm	15	103	14.6%

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.