Gene

TFCP2

transcription factor CP2

Explore in graph →CI-GENE-00034988HGNC:11748 ENSG00000135457 NCBI 7024 Cancer geneApproved

Curated evidence

Clinical evidence (8)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–8 of 8 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
TFCP2 Fusion3
(diagnostic)	Spindle Cell Rhabdomyosarcoma	Diagnostic	C	Supports Positive	4	accepted	EID12825 This study presented clinicopathological and molecular findings of TFCP2-rearranged rhabdomyosarcomas with epithelioid and/or spindle cell morphology. The cohort comprised 14 cases, including 3 index … (full text at CIViC) PMID 31383960 · Le Loarer et al., 2020 · Open in CIViC	civic
〃	Spindle Cell Rhabdomyosarcoma	Diagnostic	C	Supports Positive	4	accepted	EID12827 This study reported clinicopathologic and molecular features of 25 cases of fusion-driven spindle cell/sclerosing rhabdomyosarcoma (SCSRMS). The tumors occurred in bone (n=19) and soft tissue (n=6). T… (full text at CIViC) PMID 37422156 · Dehner et al., 2023 · Open in CIViC

Cohorts

Alteration frequency by cohort (1)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

gdcObserved1 cohort row · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Adrenocortical Carcinoma TCGA-ACC	Adrenal Cortical CarcinomaALIAS

Literature

Linked publications (6)

25 per page, newest first.

pubmedPublishedShowing 1–6 of 6 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

A subset of epithelioid and spindle cell rhabdomyosarcomas is associated with TFCP2 fusions and common ALK upregulation.
· Mod Pathol · 2020 · PMID 31383960 · validated civic_curation pubmed
Expanding the Spectrum of Intraosseous Rhabdomyosarcoma: Correlation Between 2 Distinct Gene Fusions and Phenotype.
· Am J Surg Pathol · 2019 · PMID 30720533 · validated civic_curation pubmed
Spindle cell rhabdomyosarcoma of bone with FUS-TFCP2 fusion: confirmation of a very recently described rhabdomyosarcoma subtype.
· Histopathology · 2018 · PMID 29758589 · validated civic_curation pubmed
Diagnostic and Therapeutic Implications of a FUS::TFCP2 Fusion and ALK Activation in a Metastatic Rhabdomyosarcoma.
· Genes Chromosomes Cancer · 2024 · PMID 39302072 · validated

TFCP2 Fusion1
(diagnostic)	Spindle Cell Rhabdomyosarcoma	Diagnostic	C	Supports Positive	4	accepted	EID12326 This 2018 study highlighted the diagnostic role of the FUS::TFCP2 fusion in spindle cell/sclerosing rhabdomyosarcoma (sRMS) through a single-case study of a primary spindle cell rhabdomyosarcoma of bo… (full text at CIViC) PMID 29758589 · Dashti et al., 2018 · Open in CIViC	civic

TFCP2 Fusion1

(diagnostic)

Spindle Cell Rhabdomyosarcoma

Diagnostic

Supports Positive

accepted

EID12326

This 2018 study highlighted the diagnostic role of the FUS::TFCP2 fusion in spindle cell/sclerosing rhabdomyosarcoma (sRMS) through a single-case study of a primary spindle cell rhabdomyosarcoma of bo… (full text at CIViC)

PMID 29758589 · Dashti et al., 2018 · Open in CIViC

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ALK Exon 2-18 Deletion + TFCP2 FusionTFCP2 ALK2
(diagnostic)	Spindle Cell Rhabdomyosarcoma	Diagnostic	C	Supports Positive	4	accepted	EID12405 A 31 year old male initially thought to have a mandibular osteosarcoma that was resected and treated with adjuvant radiation and cisplatin-doxorubicin. He had a mandibular recurrence with multiple pul… (full text at CIViC) PMID 39302072 · Csizmok et al., 2024 · Open in CIViC	civic
Alectinib	Spindle Cell Rhabdomyosarcoma	Predictive	C	Supports Sensitivity Response	2	accepted	EID12406 A 31 year old male initially thought to have a mandibular osteosarcoma that was resected and treated with adjuvant radiation and cisplatin-doxorubicin. He had a mandibular recurrence with multiple pul… (full text at CIViC) PMID 39302072 · Csizmok et al., 2024 · Open in CIViC	civic

ALK Exon 2-18 Deletion + TFCP2 FusionTFCP2 ALK2

(diagnostic)

Spindle Cell Rhabdomyosarcoma

Diagnostic

Supports Positive

accepted

EID12405

A 31 year old male initially thought to have a mandibular osteosarcoma that was resected and treated with adjuvant radiation and cisplatin-doxorubicin. He had a mandibular recurrence with multiple pul… (full text at CIViC)

PMID 39302072 · Csizmok et al., 2024 · Open in CIViC

civic

Alectinib

Spindle Cell Rhabdomyosarcoma

Predictive

Supports Sensitivity Response

accepted

EID12406

PMID 39302072 · Csizmok et al., 2024 · Open in CIViC

civic

TFCP2 Fusion2
(diagnostic)	Spindle Cell Rhabdomyosarcoma	Diagnostic	B	Supports Positive	3	accepted	EID12335 In this study, the authors investigated the diagnostic role of TFCP2 fusions in spindle cell/sclerosing rhabdomyosarcoma (SC/S-RMS), a rare and aggressive subtype of rhabdomyosarcoma. While SC/S-RMS e… (full text at CIViC) PMID 31383960 · Le Loarer et al., 2020 · Open in CIViC	civic
〃	Spindle Cell Rhabdomyosarcoma	Diagnostic	C	Supports Positive	4	accepted	EID12325 This study investigated the role of TFCP2-related gene fusions in primary intraosseous rhabdomyosarcomas (PIOS), particularly within spindle cell and sclerosing rhabdomyosarcoma subtypes. The analysis… (full text at CIViC) PMID 30720533 · Agaram et al., 2019 · Open in CIViC	civic

TFCP2 Fusion2

(diagnostic)

Spindle Cell Rhabdomyosarcoma

Diagnostic

Supports Positive

accepted

EID12335

In this study, the authors investigated the diagnostic role of TFCP2 fusions in spindle cell/sclerosing rhabdomyosarcoma (SC/S-RMS), a rare and aggressive subtype of rhabdomyosarcoma. While SC/S-RMS e… (full text at CIViC)

PMID 31383960 · Le Loarer et al., 2020 · Open in CIViC

civic

〃

Spindle Cell Rhabdomyosarcoma

Diagnostic

Supports Positive

accepted

EID12325

This study investigated the role of TFCP2-related gene fusions in primary intraosseous rhabdomyosarcomas (PIOS), particularly within spindle cell and sclerosing rhabdomyosarcoma subtypes. The analysis… (full text at CIViC)

PMID 30720533 · Agaram et al., 2019 · Open in CIViC

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