TFCP2 Fusion

CI-VAR-00001512Explore in graph →CIViC 5414

Curated evidence

Evidence by cancer (3 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–3 of 3 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Spindle Cell Rhabdomyosarcoma3
EWSR1::TFCP2 Fusion	(diagnostic)	Diagnostic	C	Supports Positive	4	accepted	EID12825 This study presented clinicopathological and molecular findings of TFCP2-rearranged rhabdomyosarcomas with epithelioid and/or spindle cell morphology. The cohort comprised 14 cases, including 3 index … (full text at CIViC) PMID 31383960 · Le Loarer et al., 2020 · Open in CIViC	civic
EWSR1::TFCP2 Fusion	(diagnostic)	Diagnostic	C	Supports Positive	3	accepted	EID12826 This study presented clinicopathological and molecular features of 11 cases of head and neck rhabdomyosarcomas (HNRMSs). The median age of the cohort was 29 years, ranging 16-74 years with no sex bias… (full text at CIViC) PMID 33382123 · Xu et al., 2021 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.