TEK T1105N and T1106N

CI-VAR-00004259Explore in graph →CIViC 3409

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Blue Rubber Bleb Nevus Syndrome2unmapped disease
TEK T1105N and T1106N	(diagnostic)	Diagnostic	C	Supports Positive	2	submitted	EID9475 Sanger sequencing of cDNA followed by targeted deep sequencing detected TEK mutations in 15/17 unrelated Blue Rubber Bleb Nevus Syndrome (BRBN) patients (32/35 lesions positive). Mutations were locate… (full text at CIViC) PMID 27519652 · Soblet et al., 2017 · Open in CIViC	civic
TEK T1105N and T1106N	(oncogenic)	Oncogenic	D	Supports Oncogenicity	3	submitted	EID9478 TIE2 double mutant (T1105N plus T1106N) and wildtype were expressed through retrovirus in Human umbilical vein endothelial cells (HUVECs). Unlike wildtype cells, the double mutant demonstrated ligand-… (full text at CIViC) PMID 27519652 · Soblet et al., 2017 · Open in CIViC

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.