Gene
SRF
serum response factor
Explore in graph →CI-GENE-00033719HGNC:11291 ENSG00000112658 NCBI 6722 Cancer geneApproved
Curated evidence
Clinical evidence (4)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 28248815
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| SRF Fusion4 | ||||||||
| (diagnostic) | Myofibroma And MyopericytomaUNRESOLVED | Diagnostic | B | Supports Positive | 4 | accepted | EID12517In this 2017 study the author included 44 cellular myofibroblastic tumors previously diagnosed as cellular myofibroma, cellular myopericytoma, or cellular myofibroblastic neoplasms (NOS), and a contro… (full text at CIViC) PMID 28248815 · Antonescu et al., 2017 · Open in CIViC | civic |
| 〃 | Myofibroma And MyopericytomaUNRESOLVED | Diagnostic | B | Supports Positive | 4 | accepted | EID12518In this 2020 study, the authors include 13 perivascular myoid tumors belonging to the previously described SRF rearranged subtype of tumors (PMID:28248815), which share morphologic features with myope… (full text at CIViC) PMID 33021523 · | |
Cohorts
Alteration frequency by cohort (2)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 33242424
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Pediatric Brain Cancer (CPTAC/CHOP, Cell 2020) brain_cptac_2020 | unmapped | Ssm | 8 | 218 | 3.7% |
Literature
Linked publications (4)
25 per page, newest first.
- Source
- PubMed (NLM)
- Dataset
- PubMed E-utilities
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)