Publication
Endometrial cancer-associated mutants of SPOP are defective in regulating estrogen receptor-α protein turnover.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (9)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 9
- geneSPOPcivic_curation1.00
- variantSPOP D140Gcivic_curation1.00
- variantSPOP E47Kcivic_curation1.00
- variantSPOP E50Kcivic_curation1.00
- variantSPOP G75Rcivic_curation1.00
- variantSPOP M117Icivic_curation1.00
- variantSPOP M117Vcivic_curation1.00
- variantSPOP R121Qcivic_curation1.00
- variantSPOP S80Rcivic_curation1.00
Curated evidence
Evidence citing this paper (9)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 25766326
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| SPOP D140G1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | accepted | EID9338SPOP is a ubiquitin ligase complex adapter protein capable of targeting ER-alpha (encoded by ESR1) for ubiquitination and subsequent degradation. Preclinical experiments showed that the MATH domain of… (full text at CIViC) PMID 25766326 · Zhang et al., 2015 · Open in CIViC | civic |
| SPOP E47K1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | accepted | EID9332SPOP is a ubiquitin ligase complex adapter protein capable of targeting ER-alpha (encoded by ESR1) for ubiquitination and subsequent degradation. Preclinical experiments showed that the MATH domain of… (full text at CIViC) PMID 25766326 · Zhang et al., 2015 · Open in CIViC | civic |
| SPOP E50K1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | accepted | EID9334SPOP is a ubiquitin ligase complex adapter protein capable of targeting ER-alpha (encoded by ESR1) for ubiquitination and subsequent degradation. Preclinical experiments showed that the MATH domain of… (full text at CIViC) PMID 25766326 · Zhang et al., 2015 · Open in CIViC | civic |
| SPOP G75R1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | accepted | EID9335SPOP is a ubiquitin ligase complex adapter protein capable of targeting ER-alpha (encoded by ESR1) for ubiquitination and subsequent degradation. Preclinical experiments showed that the MATH domain of… (full text at CIViC) PMID 25766326 · Zhang et al., 2015 · Open in CIViC | civic |
| SPOP M117I1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 3 | accepted | EID9216The ubiquitin ligase complex adaptor protein SPOP was shown to directly interact with ER-alpha in co-immunoprecipitation (co-IP) experiments when ectopically expressed in 293T cells and under endogeno… (full text at CIViC) PMID 25766326 · Zhang et al., 2015 · Open in CIViC | civic |
| SPOP M117V1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 3 | accepted | EID9131SPOP is a ubiquitin ligase complex adapter protein capable of targeting ER-alpha (encoded by ESR1) for ubiquitination and subsequent degradation. Preclinical experiments showed that the MATH domain of… (full text at CIViC) PMID 25766326 · Zhang et al., 2015 · Open in CIViC | civic |
| SPOP P94A1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | submitted | EID9337SPOP is a ubiquitin ligase complex adapter protein capable of targeting ER-alpha (encoded by ESR1) for ubiquitination and subsequent degradation. Preclinical experiments showed that the MATH domain of… (full text at CIViC) PMID 25766326 · Zhang et al., 2015 · Open in CIViC | civic |
| SPOP R121Q1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 3 | accepted | EID9215The ubiquitin ligase complex adaptor protein SPOP was shown to directly interact with ER-alpha in co-immunoprecipitation (co-IP) experiments when ectopically expressed in 293T cells and under endogeno… (full text at CIViC) PMID 25766326 · Zhang et al., 2015 · Open in CIViC | civic |
| SPOP S80R1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | accepted | EID9336SPOP is a ubiquitin ligase complex adapter protein capable of targeting ER-alpha (encoded by ESR1) for ubiquitination and subsequent degradation. Preclinical experiments showed that the MATH domain of… (full text at CIViC) PMID 25766326 · Zhang et al., 2015 · Open in CIViC | civic |