Variant · Snv
SOS1 NM_005633.4(SOS1):c.1074+5G>C
CI-VAR-00008644Explore in graph →NM_005633.4:c.1074+5G>CClinVar 45343 rs145155424
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-24
- Retrieved
- Sep 29, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260929-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 45343 | Benign | reviewed by expert panel | 3 | RASopathy; Fibromatosis, gingival, 1; Noonan syndrome 4; Noonan syndrome and Noonan-related syndrome; Cardiovascular phenotype; Sarcoma; Lymphoma; Ovarian serous cystadenocarcinoma; Thymoma; Acute myeloid leukemia; Nonpapillary renal cell carcinoma; Lung cancer; Familial pancreatic carcinoma; Gastric cancer; Familial cancer of breast | germline | 22 | Apr 18, 2017 | clinvar |