Gene

SMAD2

SMAD family member 2

Explore in graph →CI-GENE-00031377HGNC:6768 ENSG00000175387 NCBI 4087 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
SMAD2 S276L1
(functional)	—UNRESOLVED	Functional	D	Supports Loss Of Function	1	accepted	EID11039 SMAD2 S276L mutations were observed in 3/744 cases of colorectal cancer. This mutation was introduced by site-directed mutagenesis and transfected into HEK293T cells. The interaction of wildtype and m… (full text at CIViC) PMID 23139211 · Fleming et al., 2013 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (51)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved51 cohort rows (showing 1, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Soft Tissue and Bone Sarcoma (MSK, Nat Commun 2022) sarcoma_msk_2022	unmapped	Ssm	5	7,494

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

SMAD2, SMAD3 and SMAD4 mutations in colorectal cancer.
· Cancer Res · 2013 · PMID 23139211 · validated civic_curation pubmed