Gene

RRM1

ribonucleotide reductase catalytic subunit M1

Explore in graph →CI-GENE-00029533HGNC:10451 ENSG00000167325 NCBI 6240 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (14)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–14 of 14 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
RRM1 Decreased RNA expression1
Fluorouracil	Malignant Colorectal NeoplasmCURATED_BROADER	Predictive	D	Supports Sensitivity Response

Cohorts

Alteration frequency by cohort (0)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

Data not yet available

No cohort frequency recorded for this gene.

Literature

Linked publications (7)

25 per page, newest first.

pubmedPublishedShowing 1–7 of 7 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

The tailored chemotherapy based on RRM1 immunohistochemical expression in patients with advanced non-small cell lung cancer.
· Cancer Biomark · 2013 · PMID 24595080 · validated civic_curation pubmed
Response to first-line chemotherapy in patients with non-small cell lung cancer according to RRM1 expression.
· PLoS One · 2014 · PMID 24647522 · validated civic_curation pubmed
Significance of RRM1 and ERCC1 expression in resectable pancreatic adenocarcinoma.
· Oncogene · 2009 · PMID 19543324 · validated civic_curation pubmed
Involvement of ribonucleotide reductase M1 subunit overexpression in gemcitabine resistance of human pancreatic cancer.
· Int J Cancer · 2007 · PMID 17131328 · validated civic_curation

RRM1 Overexpression1
Gemcitabine	Malignant Pancreatic Neoplasm	Predictive	D	Supports Resistance	2	accepted	EID1859 The mRNA expression level of RRM1 was analyzed by RT-PCR in 3 human pancreatic cancer cell lines cultured in incrementally increased concentrations of gemcitabine. Expression levels of RRM1 progressiv… (full text at CIViC) PMID 17224927 · Nakano et al., 2007 · Open in CIViC	civic

RRM1 Overexpression1

Gemcitabine

Malignant Pancreatic Neoplasm

Predictive

Supports Resistance

accepted

EID1859

The mRNA expression level of RRM1 was analyzed by RT-PCR in 3 human pancreatic cancer cell lines cultured in incrementally increased concentrations of gemcitabine. Expression levels of RRM1 progressiv… (full text at CIViC)

PMID 17224927 · Nakano et al., 2007 · Open in CIViC

civic

RRM1 Underexpression12
(prognostic)	Lung Non-Small Cell CarcinomaCURATED_BROADER	Prognostic	B	Supports Better Outcome	2	submitted	EID8024 Expression level of RRM1 was evaluated in 61 NSCLC samples with RT-qPCR. Low expression of RRM1 was associated with longer median survival time (13.9 versus 10.9 months, P = 0.039). However, RRM1 expr… (full text at CIViC) PMID 16980606 · Ceppi et al., 2006 · Open in CIViC	civic
Gemcitabine	Lung Non-Small Cell CarcinomaCURATED_BROADER	Predictive	B	Supports Sensitivity Response	4	accepted	EID5530 In this study, 229 tumors were analyzed for RRM1 expression. This resulted in 146 that were negative for RRM1 expression and 83 that were positive. These tumors were studied for a relationship between… (full text at CIViC) PMID 24647522 · Dong et al., 2014 · Open in CIViC	civic
〃	Malignant Pancreatic Neoplasm	Predictive	B	Supports Sensitivity Response	3	accepted	EID5506 There were 68 patients enrolled in this study, 28 of which were treated with gemcitabine. Of those 28, 14 patients had a low RRM1 expression and 14 had a high RRM1 expression. Only the patients with … (full text at CIViC) PMID 19543324 · Akita et al., 2009 · Open in CIViC	civic
〃	Malignant Pancreatic Neoplasm	Predictive	B	Supports Sensitivity Response	3	accepted	EID5508 In this study, human pancreatic carcinoma cell line MiaPaCa2, which is a gemcitabine-sensitive cell line, was used for the establishment of chemoresistant cells MiaPaCa2-RG. Analysis for identifying g… (full text at CIViC) PMID 17131328 · Nakahira et al., 2007 · Open in CIViC	civic
Carboplatin + GemcitabineCombination	Lung Non-Small Cell CarcinomaCURATED_BROADER	Predictive	B	Supports Sensitivity Response	3	accepted	EID10143 As part of a randomized phase III trial (USO-03012) in advanced NSCLC of gemcitabine vs. combination gemcitabine and carboplatin, protein expression levels for RRM1 (n=69) and ERCC1 (n=65) were evalua… (full text at CIViC) PMID 19884554 · Reynolds et al., 2009 · Open in CIViC	civic
Cisplatin + GemcitabineCombination	Lung Non-Small Cell CarcinomaCURATED_BROADER	Predictive	B	Supports Sensitivity Response	4	accepted	EID2905 In the personalized therapy group of this study, patients received chemotherapy based on RRM-1 IHC expression levels, whereas the standard therapy group received non-customized chemotherapy. There wer… (full text at CIViC) PMID 24595080 · Nie et al., 2013 · Open in CIViC	civic
〃	Lung Non-Small Cell CarcinomaCURATED_BROADER	Predictive	B	Supports Sensitivity Response	4	submitted	EID6436 Of the 100 patients in this study, only 81 of them were relevant to the study of both RRM1 and ERCC1. In those 81, there was a strong correlation between mRNA expression levels of RRM1 and ERCC1(Spea… (full text at CIViC) PMID 14977831 · Rosell et al., 2004 · Open in CIViC	civic
〃	Lung Non-Small Cell CarcinomaCURATED_BROADER	Predictive	B	Supports Sensitivity Response	2	submitted	EID6432 22 patients were treated in the gemcitabine/cisplatin arm in this 3 arm clinical study. RRM1 mRNA levels seemed to have a highly significant effect on survival (P=0.0028) and time to progression (P=0.… (full text at CIViC) PMID 12789263 · Rosell et al., 2003 · Open in CIViC	civic
Gemcitabine + Platinum CompoundCombination	Lung Non-Small Cell CarcinomaCURATED_BROADER	Predictive	B	Supports Sensitivity Response	3	submitted	EID6434 A correlation was observed between the expression levels of ERCC1, RRM1, and XPD across all patients. In patients with non small cell lung cancer, patients in the bottom quartertile of RRM1 levels ha… (full text at CIViC) PMID 15217961 · Rosell et al., 2004 · Open in CIViC	civic
Cisplatin + Gemcitabine + PaclitaxelCombination	Lung Non-Small Cell CarcinomaCURATED_BROADER	Predictive	B	Does Not Support Sensitivity Response	3	rejected	EID12043 The study began with a total of 443 patients with advanced NSCLC that were randomly assigned to either regimen A (paclitaxel and cisplatin with gemcitabine) or regimen B (cisplatin and vinorelbine). R… (full text at CIViC) PMID 27276561 · Papaemmanuil et al., 2016 · Open in CIViC	civic
Cisplatin + Gemcitabine + PaclitaxelCombination	Lung Non-Small Cell CarcinomaCURATED_BROADER	Predictive	B	Does Not Support Sensitivity Response	3	submitted	EID12044 The study began with a total of 443 patients with advanced NSCLC that were randomly assigned to either regimen A (paclitaxel and cisplatin with gemcitabine) or regimen B (cisplatin and vinorelbine). R… (full text at CIViC) PMID 23038758 · Vilmar et al., 2013 · Open in CIViC	civic
Gemcitabine + Paclitaxel + VinorelbineSubstitutes	Lung Non-Small Cell CarcinomaCURATED_BROADER	Predictive	B	Supports Sensitivity Response	3	accepted	EID5599 The study began with a total of 443 patients that were randomly assigned to either regimen A (Paclitaxel and cisplatin with gemcitabine) or regimen B ( cisplatin and vinorelbine). Of those patients, 2… (full text at CIViC) PMID 23038758 · Vilmar et al., 2013 · Open in CIViC	civic

RRM1 Underexpression12

(prognostic)

Lung Non-Small Cell CarcinomaCURATED_BROADER

Prognostic

Supports Better Outcome

submitted

EID8024

Expression level of RRM1 was evaluated in 61 NSCLC samples with RT-qPCR. Low expression of RRM1 was associated with longer median survival time (13.9 versus 10.9 months, P = 0.039). However, RRM1 expr… (full text at CIViC)

PMID 16980606 · Ceppi et al., 2006 · Open in CIViC

civic

Gemcitabine

Lung Non-Small Cell CarcinomaCURATED_BROADER

Predictive

Supports Sensitivity Response

accepted

EID5530

In this study, 229 tumors were analyzed for RRM1 expression. This resulted in 146 that were negative for RRM1 expression and 83 that were positive. These tumors were studied for a relationship between… (full text at CIViC)

PMID 24647522 · Dong et al., 2014 · Open in CIViC

civic

〃

Malignant Pancreatic Neoplasm

Predictive

Supports Sensitivity Response

accepted

EID5506

There were 68 patients enrolled in this study, 28 of which were treated with gemcitabine. Of those 28, 14 patients had a low RRM1 expression and 14 had a high RRM1 expression. Only the patients with … (full text at CIViC)

PMID 19543324 · Akita et al., 2009 · Open in CIViC

civic

〃

Malignant Pancreatic Neoplasm

Predictive

Supports Sensitivity Response

accepted

EID5508

In this study, human pancreatic carcinoma cell line MiaPaCa2, which is a gemcitabine-sensitive cell line, was used for the establishment of chemoresistant cells MiaPaCa2-RG. Analysis for identifying g… (full text at CIViC)

PMID 17131328 · Nakahira et al., 2007 · Open in CIViC

civic

Carboplatin + GemcitabineCombination

Lung Non-Small Cell CarcinomaCURATED_BROADER

Predictive

Supports Sensitivity Response

accepted

EID10143

As part of a randomized phase III trial (USO-03012) in advanced NSCLC of gemcitabine vs. combination gemcitabine and carboplatin, protein expression levels for RRM1 (n=69) and ERCC1 (n=65) were evalua… (full text at CIViC)

PMID 19884554 · Reynolds et al., 2009 · Open in CIViC

civic

Cisplatin + GemcitabineCombination

Lung Non-Small Cell CarcinomaCURATED_BROADER

Predictive

Supports Sensitivity Response

accepted

EID2905

In the personalized therapy group of this study, patients received chemotherapy based on RRM-1 IHC expression levels, whereas the standard therapy group received non-customized chemotherapy. There wer… (full text at CIViC)

PMID 24595080 · Nie et al., 2013 · Open in CIViC

civic

〃

Lung Non-Small Cell CarcinomaCURATED_BROADER

Predictive

Supports Sensitivity Response

submitted

EID6436

Of the 100 patients in this study, only 81 of them were relevant to the study of both RRM1 and ERCC1. In those 81, there was a strong correlation between mRNA expression levels of RRM1 and ERCC1(Spea… (full text at CIViC)

PMID 14977831 · Rosell et al., 2004 · Open in CIViC

civic

〃

Lung Non-Small Cell CarcinomaCURATED_BROADER

Predictive

Supports Sensitivity Response

submitted

EID6432

22 patients were treated in the gemcitabine/cisplatin arm in this 3 arm clinical study. RRM1 mRNA levels seemed to have a highly significant effect on survival (P=0.0028) and time to progression (P=0.… (full text at CIViC)

PMID 12789263 · Rosell et al., 2003 · Open in CIViC

civic

Gemcitabine + Platinum CompoundCombination

Lung Non-Small Cell CarcinomaCURATED_BROADER

Predictive

Supports Sensitivity Response

submitted

EID6434

A correlation was observed between the expression levels of ERCC1, RRM1, and XPD across all patients. In patients with non small cell lung cancer, patients in the bottom quartertile of RRM1 levels ha… (full text at CIViC)

PMID 15217961 · Rosell et al., 2004 · Open in CIViC

civic

Cisplatin + Gemcitabine + PaclitaxelCombination

Lung Non-Small Cell CarcinomaCURATED_BROADER

Predictive

Does Not Support Sensitivity Response

rejected

EID12043

The study began with a total of 443 patients with advanced NSCLC that were randomly assigned to either regimen A (paclitaxel and cisplatin with gemcitabine) or regimen B (cisplatin and vinorelbine). R… (full text at CIViC)

PMID 27276561 · Papaemmanuil et al., 2016 · Open in CIViC

civic

Cisplatin + Gemcitabine + PaclitaxelCombination

Lung Non-Small Cell CarcinomaCURATED_BROADER

Predictive

Does Not Support Sensitivity Response

submitted

EID12044

PMID 23038758 · Vilmar et al., 2013 · Open in CIViC

civic

Gemcitabine + Paclitaxel + VinorelbineSubstitutes

Lung Non-Small Cell CarcinomaCURATED_BROADER

Predictive

Supports Sensitivity Response

accepted

EID5599

The study began with a total of 443 patients that were randomly assigned to either regimen A (Paclitaxel and cisplatin with gemcitabine) or regimen B ( cisplatin and vinorelbine). Of those patients, 2… (full text at CIViC)

PMID 23038758 · Vilmar et al., 2013 · Open in CIViC

civic