Publication
Gemcitabine chemoresistance and molecular markers associated with gemcitabine transport and metabolism in human pancreatic cancer cells.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (6)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 6
- cancerMalignant Pancreatic Neoplasmcivic_curation1.00
- drugGemcitabinecivic_curation1.00
- geneRRM1civic_curation1.00
- geneRRM2civic_curation1.00
- variantRRM1 Overexpressioncivic_curation1.00
- variantRRM2 OVEREXPRESSIONcivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 17224927
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| RRM1 Overexpression1 | ||||||||
| Gemcitabine | Malignant Pancreatic Neoplasm | Predictive | D | Supports Resistance | 2 | accepted | EID1859The mRNA expression level of RRM1 was analyzed by RT-PCR in 3 human pancreatic cancer cell lines cultured in incrementally increased concentrations of gemcitabine. Expression levels of RRM1 progressiv… (full text at CIViC) PMID 17224927 · Nakano et al., 2007 · Open in CIViC | civic |
| RRM2 OVEREXPRESSION1 | ||||||||
| Gemcitabine | Malignant Pancreatic Neoplasm | Predictive | D | Supports Resistance | 2 | accepted | EID1860The mRNA expression level of RRM2 was analyzed by RT-PCR in 3 human pancreatic cancer cell lines cultured in incrementally increased concentrations of gemcitabine. Expression levels of RRM2 progressi… (full text at CIViC) PMID 17224927 · Nakano et al., 2007 · Open in CIViC | civic |