Gene

REL

REL proto-oncogene, NF-kB subunit

Explore in graph →CI-GENE-00023315HGNC:9954 ENSG00000162924 NCBI 5966 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
REL AMPLIFICATION1
(diagnostic)	Diffuse Large B-Cell LymphomaCURATED_BROADER	Diagnostic	B	Supports Positive	4	accepted	EID409 Amplification of REL is shown to be associated with germinal-center B-cell–like diffuse large-B-cell lymphomas. PMID 12075054 · Rosenwald et al., 2002 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (23)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved23 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Pancreatic Adenocarcinoma (MSK, 2025) paad_msk_2025	Pancreatic Adenocarcinoma	Ssm	2	29	6.9%	50

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma.
· N Engl J Med · 2002 · PMID 12075054 · validated civic_curation pubmed