Gene

RASGRF1

Ras protein specific guanine nucleotide releasing factor 1

Explore in graph →CI-GENE-00023006HGNC:9875 ENSG00000058335 NCBI 5923 Approved

Curated evidence

Clinical evidence (3)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–3 of 3 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
RASGRF1 Fusion1
(oncogenic)	Malignant NeoplasmALIAS	Oncogenic	D	Supports Oncogenicity	2	submitted	EID12147 25 tumors from individuals with lung adca who have <= 10 pack-year smoking history underwent whole exome sequencing and RNA-seq. 5 tumors did not identify an established oncogenic driver. In one (tumo… (full text at CIViC) PMID 35247929 · Hunihan et al., 2022 · Open in CIViC	civic
RASGRF1 Fusion1
(oncogenic)	Lung Adenocarcinoma	Oncogenic	D	Supports Oncogenicity	4	submitted	EID10716 25 tumors from individuals with lung adca who have <= 10 pack-year smoking history underwent whole exome sequencing and RNA-seq. 5 tumors did not identify an established oncogenic driver. In one (tumo…

Cohorts

Alteration frequency by cohort (6)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved6 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
NCI-60 Cell Lines (NCI, Cancer Res 2012) cellline_nci60	unmapped	Ssm	10	60	16.7%

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.