Gene
QKI
QKI, KH domain containing RNA binding
Explore in graph →CI-GENE-00022657HGNC:21100 ENSG00000112531 NCBI 9444 Cancer geneApproved
Curated evidence
Clinical evidence (3)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 26829751
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| QKI Fusion3 | ||||||||
| (diagnostic) | Angiocentric Glioma | Diagnostic | B | Supports Positive | 4 | accepted | EID11065A comprehensive genomic analysis was conducted on 172 cases of pediatric low-grade gliomas (PLGGs) across various histologic subtypes, utilizing whole-genome sequencing (WGS) and/or RNA sequencing. Th… (full text at CIViC) PMID 26829751 · Bandopadhayay et al., 2016 · Open in CIViC | civic |
| 〃 | Angiocentric Glioma | Diagnostic | B | Supports Positive | 4 | accepted | EID11773The study compiled clinicopathologic and molecular features of 46 gliomas with a MYB or MYBL1 alteration diagnosed at a single center. The tumors showed low-grade histopathologic features and were bro… (full text at CIViC) PMID 31595312 · Chiang et al., 2019 · Open in CIViC | |
Cohorts
Alteration frequency by cohort (1)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 39305899
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Sarcoma (UCLA, Cell 2024) sarcoma_ucla_2024 | unmapped | Ssm | 1 | 63 | 1.6% | 182 |
Literature
Linked publications (3)
25 per page, newest first.
- Source
- PubMed (NLM)
- Dataset
- PubMed E-utilities
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
· Nat Genet · 2016 · PMID 26829751 · validated civic_curation pubmed
- A single-center study of the clinicopathologic correlates of gliomas with a MYB or MYBL1 alteration.
· Acta Neuropathol · 2019 · PMID 31595312 · validated civic_curation pubmed
· Acta Neuropathol · 2016 · PMID 26810070 · validated civic_curation pubmed