PRKN R275W

CI-VAR-00003803Explore in graph →CIViC 2753

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Unmapped disease1unmapped disease
PRKN R275W	(functional)	Functional	D	Supports Loss Of Function	2	submitted	EID7439 Experimental studies have shown that this variant impairs the function of the PARK2 protein by causing defects in solubility, aggregation, enzymatic activity or targeting proteins to the proteasome fo… (full text at CIViC) PMID 16049031 · Sriram et al., 2005 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.