PLAG1 — gene · CancerIndex

Curated evidence

Clinical evidence (3)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–3 of 3 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
PLAG1 Fusion1
Futibatinib	Malignant Head and Neck NeoplasmALIAS	Predictive	C	Supports Sensitivity Response	1	submitted	EID11639 In a phase 1 multihistology trial of the FGFR1/2/3/4 inhibitor futibatinib, an objective response rate of 13.7% was seen with responses in a broad spectrum of tumors and across a broad spectrum of FGF… (full text at CIViC) PMID 34551969 · Meric-Bernstam et al., 2022 · Open in CIViC	civic
PLAG1 Fusion2
(diagnostic)	Skin Mixed TumorALIAS	Diagnostic	B	Supports Positive	4	submitted	EID13224 In a molecular analysis comparing 46 apocrine cutaneous mixed tumors (CMTs) with 45 salivary gland pleomorphic adenomas (PAs), TRPS1::PLAG1 was the predominant PLAG1 fusion in CMTs and was significant…

Cohorts

Alteration frequency by cohort (2)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved2 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Breast Invasive Carcinoma (British Columbia, Nature 2012) brca_bccrc	Invasive Breast Carcinoma	Ssm	2	65

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.