PLAG1 Fusion

CI-VAR-00001466Explore in graph →CIViC 5165

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Skin Mixed Tumor1
TRPS1::PLAG1 Fusion	(diagnostic)	Diagnostic	B	Supports Positive	4	submitted	EID13224 In a molecular analysis comparing 46 apocrine cutaneous mixed tumors (CMTs) with 45 salivary gland pleomorphic adenomas (PAs), TRPS1::PLAG1 was the predominant PLAG1 fusion in CMTs and was significant… (full text at CIViC) PMID 39468990 · Alsugair et al., 2024 · Open in CIViC	civic
Solid Neoplasm1
TRPS1::PLAG1 Fusion	(diagnostic)	Diagnostic	C	Supports Positive	2	submitted	EID12433 This study describes two novel PLAG1 fusions, TRPS1–PLAG1 and NDRG1–PLAG1, identified in histologically confirmed cases of chondroid syringoma. Both fusions involve promoter swapping, placing PLAG1 ex… (full text at CIViC) PMID 32345665 · Panagopoulos et al., 2020 ·

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.