PIK3CB E1051K

CI-VAR-00000656Explore in graph →CIViC 3290

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Unmapped disease1unmapped disease
PIK3CB E1051K	(functional)	Functional	D	Supports Gain Of Function	4	submitted	EID9174 The PIK3CB kinase domain mutation E1051K has been identified in several cancer types. Functional characterization of E1051K showed that it has higher affinity for ATP and greater activity than wild-ty… (full text at CIViC) PMID 29279775 · Whale et al., 2017 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.