PDGFB — gene · CancerIndex

Curated evidence

Clinical evidence (16)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–16 of 16 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
PDGFB Fusion13
(diagnostic)	Dermatofibrosarcoma Protuberans	Diagnostic	B	Supports Positive	4	accepted	EID9787 This study analyzed 27 formalin-fixed-paraffin-embedded samples of patients with known dermatofibrosarcoma protuberans (DFSP) using a newly designed multiplex RT-PCR assay. The assay identified COL1A1… (full text at CIViC) PMID 17950782 · Patel et al., 2008 · Open in CIViC	civic
〃	Dermatofibrosarcoma Protuberans	Diagnostic	B	Supports Positive	4	accepted	EID12417 The authors studied 27 archival formalin-fixed, paraffin-embedded (FFPE) samples of dermatofibrosarcoma protuberans (DFSP) cases obtained from Texas Children's Hospital and University of Texas MD Ande… (full text at CIViC) PMID 17950782 · Patel et al., 2008 · Open in CIViC

Cohorts

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

Data not yet available

No cohort frequency recorded for this gene.

Literature

25 per page, newest first.

pubmedPublishedShowing 1–6 of 6 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

PDGFB Rearrangement3
Imatinib Mesylate	Dermatofibrosarcoma Protuberans	Predictive	C	Supports Sensitivity Response	3	submitted	EID10312 An 18-month-old female patient presented with a history of an enlarging, subcutaneous mass in her right lower extremity since birth. A biopsy was performed and the findings were typical of Dermatofibr… (full text at CIViC) PMID 15503291 · Price et al., 2005 · Open in CIViC	civic
〃	Dermatofibrosarcoma Protuberans	Predictive	C	Supports Sensitivity Response	2	submitted	EID10330 In this retrospective study, two patients with locally advanced Dermatofibrosarcoma Protuberans (DFSP) and two patients with recurrent DFSP received imatinib treatment prior to undergoing Mohs surgery… (full text at CIViC) PMID 19620561 · Han et al., 2009 · Open in CIViC	civic
Sorafenib Tosylate	Dermatofibrosarcoma Protuberans	Predictive	C	Supports Sensitivity Response	1	submitted	EID10333 In this case report, a 36-year-old male is presented with an advanced and recurrent Dermatofibrosarcoma Protuberans (DFSP) lesion. Following the third relapse and a round of radiotherapy, he was put o… (full text at CIViC) PMID 23557478 · Kamar et al., 2013 · Open in CIViC	civic