Loading cancer entity…
Loading cancer entity…
Variants & evidence
18 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.
| Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|
| CDKN2A Loss1 | |||||||
| Palbociclib | Predictive | D | Supports Sensitivity Response | 2 | accepted | EID1881An imatinib-resistant cell line, DFSP105, was established from a dermatofibrosarcoma protuberans which had progressed to a high-grade fibrosarcomatous DFSP. The disease-associated COL1A1-PDGFB fusion … (full text at CIViC) PMID 25852058 · Eilers et al., 2015 · Open in CIViC | civic |
| PDGFB Fusion12 | |||||||
| (diagnostic) | Diagnostic | B | Supports Positive | 4 | accepted | EID9787This study analyzed 27 formalin-fixed-paraffin-embedded samples of patients with known dermatofibrosarcoma protuberans (DFSP) using a newly designed multiplex RT-PCR assay. The assay identified COL1A1… (full text at CIViC) PMID 17950782 · Patel et al., 2008 · Open in CIViC | civic |
| 〃 | Diagnostic | B | Supports Positive | 4 | accepted | EID12417The authors studied 27 archival formalin-fixed, paraffin-embedded (FFPE) samples of dermatofibrosarcoma protuberans (DFSP) cases obtained from Texas Children's Hospital and University of Texas MD Ande… (full text at CIViC) PMID 17950782 · Patel et al., 2008 · Open in CIViC | civic |
| 〃 | Diagnostic | B | Supports Positive | 4 | accepted | EID12418In this study, paraffin-embedded tissue microarray (TMA) evaluation of translocation t(17;22)(q22;q13) was performed on 40 tissue samples from 24 female and 16 male DFSP patients (37 primary tumors, 3… | |
| PDGFD Fusion1 | |||||||
| (diagnostic) | Diagnostic | C | Supports Positive | 3 | submitted | EID11732In a cohort of 20 patients with dermatofibrosarcoma protuberans that were previously negative for COL1A1::PDGFB fusion with fluorescence in situ hybridization, RNA-sequencing was applied. novel and re… (full text at CIViC) PMID 29955147 · Dadone-Montaudié et al., 2018 · Open in CIViC | civic |
| PDGFB Rearrangement3 | |||||||
| Imatinib Mesylate | Predictive | C | Supports Sensitivity Response | 3 | submitted | EID10312An 18-month-old female patient presented with a history of an enlarging, subcutaneous mass in her right lower extremity since birth. A biopsy was performed and the findings were typical of Dermatofibr… (full text at CIViC) PMID 15503291 · Price et al., 2005 · Open in CIViC | civic |
| 〃 | Predictive | C | Supports Sensitivity Response | 2 | submitted | EID10330In this retrospective study, two patients with locally advanced Dermatofibrosarcoma Protuberans (DFSP) and two patients with recurrent DFSP received imatinib treatment prior to undergoing Mohs surgery… (full text at CIViC) PMID 19620561 · Han et al., 2009 · Open in CIViC | civic |
| Sorafenib Tosylate | Predictive | C | Supports Sensitivity Response | 1 | submitted | EID10333In this case report, a 36-year-old male is presented with an advanced and recurrent Dermatofibrosarcoma Protuberans (DFSP) lesion. Following the third relapse and a round of radiotherapy, he was put o… | |
| PDGFRB Overexpression1 | |||||||
| Sunitinib | Predictive | C | Supports Sensitivity Response | 3 | accepted | EID7992A 37-year-old man presented with dermatofibrosarcoma protuberans (DFSP). Post resection, multiple nodular metastases were found in both lungs and the disease progressed following treatments with cytot… (full text at CIViC) PMID 29760553 · Xiao et al., 2018 · Open in CIViC | civic |
Data updated 22 hours agoSource updated unknownsource: civic (CC0)
Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.
PMID 21111450 · Segura et al., 2011 · Open in CIViC
| civic |
| (oncogenic) | Oncogenic | B | Supports Oncogenicity | 3 | accepted | EID10314In this study, 57 cases of dermatofibrosarcoma protuberans (DFSP) were evaluated. The COL1A1-PDGFB fusion was detected in 42 (74%) out of the 57 sample after performing targeted PCR amplification and … (full text at CIViC) PMID 17431412 · Takahira et al., 2007 · Open in CIViC | civic |
| (diagnostic) | Diagnostic | B | Supports Positive | 3 | accepted | EID11729In this 2022 study by Peng et al., the authors performed whole-genome sequencing on 53 tumor-normal pairs from patients with Dermatofibrosarcoma Protuberans (DFSP) to define its comprehensive genomic … (full text at CIViC) PMID 35441365 · Peng et al., 2022 · Open in CIViC | civic |
| 〃 | Diagnostic | C | Supports Positive | 3 | accepted | EID12416The is a cytogenetic case study of a 10-year-old female with pure pigmented dermatofibrosarcoma protuberans (DFSP), also called Bednar tumor, on her right shoulder. Karyotype of tumor cells was 47,XX … (full text at CIViC) PMID 16843106 · Craver et al., 2006 · Open in CIViC | civic |
| Imatinib | Predictive | A | Supports Sensitivity Response | 4 | submitted | EID11271In this phase II, open-label, single-arm trial, 106 patients with 40 different malignancies were enrolled (78.5% solid tumors, 21.5% hematologic malignancies), including 12 with COL1A1-PDGFB fusion-po… (full text at CIViC) PMID 18451237 · Heinrich et al., 2008 · Open in CIViC | civic |
| Imatinib Mesylate | Predictive | B | Supports Sensitivity Response | 4 | submitted | EID10336In this non-controlled phase 2 clinical trial, 25 patients with primary or recurrent Dermatofibrosarcoma Protuberans (DFSP) were recruited. Only 21 had the t(17;22) COL1A-PDGFB fusion as detected thro… (full text at CIViC) PMID 20439456 · Kérob et al., 2010 · Open in CIViC | civic |
| 〃 | Predictive | B | Supports Sensitivity Response | 2 | submitted | EID10332Ten patients with Dermatofibrosarcoma Protuberans (DFSP) were enrolled in phase II study to investigate the response to imatinib in locally advanced or metastatic DFSP. Eight of the ten patients had l… (full text at CIViC) PMID 15681532 · McArthur et al., 2005 · Open in CIViC | civic |
| 〃 | Predictive | D | Supports Sensitivity Response | 4 | submitted | EID10334In this study, DFSP-transformed cell lines (4A and 5A) were used in-vitro and in-vivo to investigate the possibility of blocking the autocrine loop that forms as a result of the t(17;22) COL1A1-PDGFB … (full text at CIViC) PMID 11291071 · Greco et al., 2001 · Open in CIViC | civic |
| 〃 | Predictive | D | Supports Sensitivity Response | 4 | submitted | EID10335In this study, NIH3T3 cell lines were used to characterize the COLIA1/PDGFB fusion protein functionally and structurally in Dermatofibrosarcoma Protuberans (DFSP). The cell lines B5/5 (COLIA1/PDGFB tr… (full text at CIViC) PMID 10446987 · Shimizu et al., 1999 · Open in CIViC | civic |
| Sunitinib | Predictive | C | Supports Sensitivity Response | 3 | accepted | EID7991A 37-year-old man presented with dermatofibrosarcoma protuberans (DFSP). Post resection, multiple nodular metastases were found in both lungs and the disease progressed following treatments with cytot… (full text at CIViC) PMID 29760553 · Xiao et al., 2018 · Open in CIViC | civic |
PMID 23557478 · Kamar et al., 2013 · Open in CIViC
| civic |