PDGFB Fusion

CI-VAR-00001286Explore in graph →CIViC 2972

Curated evidence

Evidence by cancer (13 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–13 of 13 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Dermatofibrosarcoma Protuberans12
COL1A1::PDGFB Fusion	(diagnostic)	Diagnostic	B	Supports Positive	4	accepted	EID9787 This study analyzed 27 formalin-fixed-paraffin-embedded samples of patients with known dermatofibrosarcoma protuberans (DFSP) using a newly designed multiplex RT-PCR assay. The assay identified COL1A1… (full text at CIViC) PMID 17950782 · Patel et al., 2008 · Open in CIViC	civic
COL1A1::PDGFB Fusion	(oncogenic)	Oncogenic	B	Supports Oncogenicity	3	accepted	EID10314 In this study, 57 cases of dermatofibrosarcoma protuberans (DFSP) were evaluated. The COL1A1-PDGFB fusion was detected in 42 (74%) out of the 57 sample after performing targeted PCR amplification and … (full text at CIViC) PMID 17431412 · Takahira et al., 2007 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

Malignant Uterine Neoplasm1
COL1A1::PDGFB Fusion	(diagnostic)	Diagnostic	C	Supports Positive	3	submitted	EID11730 COL1A1::PDGFB fusion is typically found in dermatofibrosarcoma protuberans, but this study revealed it could appear in uterine sarcoma, and the presence of this fusion was suggested as a feature for a… (full text at CIViC) PMID 30877273 · Croce et al., 2019 · Open in CIViC	civic