NQO1 — gene · CancerIndex

Curated evidence

Clinical evidence (3)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–3 of 3 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
NQO1 EXPRESSION1
Amrubicin	Malignant Lung Neoplasm	Predictive	D	Supports Resistance	2	accepted	EID940 Higher expression of NQO1 was correlated with decreased cytotoxicity of amrubicin (amrubicinol is the active metabolite) in 27 NSCLC and SCLC cell lines. siRNA knockdown of NQO1 (in two cell lines) i… (full text at CIViC) PMID 21964527 · Takakuwa et al., 2011 · Open in CIViC	civic
NQO1 Overexpression1
NSC84167	Pancreatic Ductal Adenocarcinoma	Predictive	D	Supports Sensitivity Response	2	accepted	EID12560 In preclinical pancreatic ductal adenocarcinoma (PDAC) models with high NQ01 expression, which indicates the NFE2L2 (NRF2) pathway activation, the small molecule NSC84167 (NSLC01, 50 mg/kg) selectivel… (full text at CIViC)

Cohorts

Alteration frequency by cohort (1)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved1 cohort row · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Breast Cancer Xenografts (British Columbia, Nature 2015) brca_bccrc_xenograft_2014	Invasive Breast Carcinoma	Ssm	12

Literature

Linked publications (2)

25 per page, newest first.

pubmedPublishedShowing 1–2 of 2 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

C609T polymorphism of NAD(P)H quinone oxidoreductase 1 as a predictive biomarker for response to amrubicin.
· J Thorac Oncol · 2011 · PMID 21964527 · validated civic_curation pubmed
Compound NSC84167 selectively targets NRF2-activated pancreatic cancer by inhibiting asparagine synthesis pathway.
· Cell Death Dis · 2021 · PMID 34247201 · validated civic_curation pubmed