Publication
C609T polymorphism of NAD(P)H quinone oxidoreductase 1 as a predictive biomarker for response to amrubicin.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
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Linked entities
Linked entities (5)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 5
- cancerMalignant Lung Neoplasmcivic_curation1.00
- drugAmrubicincivic_curation1.00
- geneNQO1civic_curation1.00
- variantNQO1 EXPRESSIONcivic_curation1.00
- variantNQO1 P187Scivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 21964527
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| NQO1 EXPRESSION1 | ||||||||
| Amrubicin | Malignant Lung Neoplasm | Predictive | D | Supports Resistance | 2 | accepted | EID940Higher expression of NQO1 was correlated with decreased cytotoxicity of amrubicin (amrubicinol is the active metabolite) in 27 NSCLC and SCLC cell lines. siRNA knockdown of NQO1 (in two cell lines) i… (full text at CIViC) PMID 21964527 · Takakuwa et al., 2011 · Open in CIViC | civic |
| NQO1 P187S1 | ||||||||
| Amrubicin | Malignant Lung Neoplasm | Predictive | D | Supports Sensitivity Response | 2 | accepted | EID941The presence of NQO1 C609T SNP (rs1800566) was associated with decreased protein expression and higher amrubicin sensitivity in 29 NSCLC and SCLC cell lines. 15 of these cell lines were genotyped for … (full text at CIViC) PMID 21964527 · Takakuwa et al., 2011 · Open in CIViC | civic |