NOTCH3 NM_000435.3(NOTCH3):c.1490C>T (p.Ser497Leu)

CI-VAR-00047726Explore in graph →p.Ser497LeuNM_000435.3:c.1490C>TClinVar 256121 rs114207045

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
256121	Benign/Likely benign	criteria provided, multiple submitters, no conflicts	2	Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1; Lateral meningocele syndrome; Myofibromatosis, infantile, 2; Thyroid cancer, nonmedullary, 1; Cervical cancer; Vascular parkinsonism; Cerebral small vessel disease; Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy; Nonpapillary renal cell carcinoma; Clear cell carcinoma of kidney; Ovarian serous cystadenocarcinoma; Thymoma	germline	13	Jun 01, 2026	clinvar