NOTCH3 NM_000435.3(NOTCH3):c.3704A>T (p.His1235Leu)

CI-VAR-00053291Explore in graph →p.His1235LeuNM_000435.3:c.3704A>TClinVar 328393 rs55882518

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
328393	Conflicting classifications of pathogenicity	criteria provided, conflicting classifications	1	Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1; Colon adenocarcinoma	germline	9	Jul 01, 2026	clinvar