Gene
MYCN
MYCN proto-oncogene, bHLH transcription factor
Explore in graph →CI-GENE-00015968HGNC:7559 ENSG00000134323 NCBI 4613 CIViC Cancer geneApproved
Curated evidence
Clinical evidence (10)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 25517749
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| MYCN Amplification8 | ||||||||
| (prognostic) | Neuroblastoma | Prognostic | A | Supports Poor Outcome | 4 | accepted | EID1328In a cohort of 1596 diagnostic tumor samples taken from patients enrolled in the Children's oncology group (COG) neuroblastoma biology protocol ANBL00B1, 1579 samples were annotated with MYCN amplific… (full text at CIViC) PMID 25517749 · Bresler et al., 2014 · Open in CIViC | civic |
| Arsenic Trioxide | MedulloblastomaCURATED_BROADER | Predictive | D | Supports Sensitivity Response | 3 | submitted | EID5327In a patient derived xenograft from a sonic hedgehog driven medulloblastoma patient, MYCN amplification conferred to resistance to SMO inhibition with Sonidegib. This PDX was shown to be responsive t… (full text at CIViC) PMID 23291299 · Kim et al., 2013 · | |
Cohorts
Alteration frequency by cohort (59)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 36493333
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Appendiceal Cancer (MSK, J Clin Oncol 2022) appendiceal_msk_2022 | Appendix Adenocarcinoma | Ssm | 1 |
Literature
Linked publications (3)
25 per page, newest first.
- Source
- PubMed (NLM)
- Dataset
- PubMed E-utilities
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)