Publication
Therapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma.
Authors not recorded
Sci Transl Med2015PMID 26537256PMC6207083stubpubmedProvenance
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
No abstract stored. Read on PubMed
Linked entities
Linked entities (4)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 4
- cancerNeuroblastomacivic_curation1.00
- drugFACT Complex-targeting Curaxin CBL0137civic_curation1.00
- geneMYCNcivic_curation1.00
- variantMYCN Amplificationcivic_curation1.00
Curated evidence
Evidence citing this paper (1)
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 26537256
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| MYCN Amplification1 | ||||||||
| FACT Complex-targeting Curaxin CBL0137 | Neuroblastoma | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID744The drug CBL0137 (a drug that interacts with SSRP1 aka FACT) exhibited a synergistic effect with standard chemotherapy (cyclophosphamide, etoposide, cisplatin, vincristine, etc.) by blocking repair of… (full text at CIViC) PMID 26537256 · Carter et al., 2015 · Open in CIViC | civic |